Pharmacokinetics I – Flashcards Questions
With Correct Answers
Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Plasma
protein binding, Tissue binding and absorption/transport
Small Intestinal transporters Influx and efflux transporters in both lumen and blood sides
Liver transporters More influx than efflux transporters in the blood side, more efflux than
influx transporters in the bile side
Kidney transporters More influx than efflux transporters in the blood side, almost equal
numbers of influx and efflux transporters in the lumen side
Blood-brain barrier transporters More efflux than influx transporters in the blood side
Transporters in cancer cells Maintain more nutrient concentrations than drugs
Post-class materials Match the columns and justify the match
Receptor Protein, RNA/DNA, Enzyme, or Lipids
With Correct Answers
Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Plasma
protein binding, Tissue binding and absorption/transport
Small Intestinal transporters Influx and efflux transporters in both lumen and blood sides
Liver transporters More influx than efflux transporters in the blood side, more efflux than
influx transporters in the bile side
Kidney transporters More influx than efflux transporters in the blood side, almost equal
numbers of influx and efflux transporters in the lumen side
Blood-brain barrier transporters More efflux than influx transporters in the blood side
Transporters in cancer cells Maintain more nutrient concentrations than drugs
Post-class materials Match the columns and justify the match
Receptor Protein, RNA/DNA, Enzyme, or Lipids
