NUR 4445 Immune Dysfunction
1.
"foreign substances that trigger the immune response"
Antigens
2. primary immune cells
leukocytes (WBC)
3. wbc stored in , spleen, bone marrow
thymus
4. two types of wbc
- (eat invadors)
- (develop antibodies)
phagocytes, lymphocytes
5. lymphocytes
-b-cells
produce
-t-cells
destroy
,antibodies, antigens
6.
group of proteins that assist in killing invading organisms
complement
7. immune funtion is in newborns
poor
8. newborn
• Neutrophils, monocytes, macrophages are present but not functioning
• Lymphocytes are produced in-utero, thymus is fully functional at birth, how- ever, and
cells are not very efficient
• Complement factors are 10-80% of an adult
well, t, b
9. •Immunoglobulin levels newborn
-IgG - crosses placenta, present at birth, then around 7-8 months, mature
levels ~ 8 years
-IgM - low at birth, increase at 1 week of age, mature level by
-IgA & IgE - present at birth, production begins at 2 weeks, mature levels
~ 6 years
-IgD - little information known, co-expressed with IgM
, declines, 1 year, not
10. immunodeficiency disorders
-primary
digeorge syndrome, wiskott-aldrich syndrome, severe combines immunodeficiency
-aquired
HIV
11. disorders
-juvenile idiopathis arthritis
-systemic lupus erythematosus
autoimmune
12. allergic reactions
-meds
-food
-
environment
13. cancers of the immune system
-
-
1.
"foreign substances that trigger the immune response"
Antigens
2. primary immune cells
leukocytes (WBC)
3. wbc stored in , spleen, bone marrow
thymus
4. two types of wbc
- (eat invadors)
- (develop antibodies)
phagocytes, lymphocytes
5. lymphocytes
-b-cells
produce
-t-cells
destroy
,antibodies, antigens
6.
group of proteins that assist in killing invading organisms
complement
7. immune funtion is in newborns
poor
8. newborn
• Neutrophils, monocytes, macrophages are present but not functioning
• Lymphocytes are produced in-utero, thymus is fully functional at birth, how- ever, and
cells are not very efficient
• Complement factors are 10-80% of an adult
well, t, b
9. •Immunoglobulin levels newborn
-IgG - crosses placenta, present at birth, then around 7-8 months, mature
levels ~ 8 years
-IgM - low at birth, increase at 1 week of age, mature level by
-IgA & IgE - present at birth, production begins at 2 weeks, mature levels
~ 6 years
-IgD - little information known, co-expressed with IgM
, declines, 1 year, not
10. immunodeficiency disorders
-primary
digeorge syndrome, wiskott-aldrich syndrome, severe combines immunodeficiency
-aquired
HIV
11. disorders
-juvenile idiopathis arthritis
-systemic lupus erythematosus
autoimmune
12. allergic reactions
-meds
-food
-
environment
13. cancers of the immune system
-
-
