NUR 221 Antibiotics Cheat Sheet

ANTIBIOTIC CHEAT SHEET
ANTIBIOTIC MOA
Inhibition of
Inhibition of Disruption of cell
nucleic acid synthesis cell wall synthesis membrane function


Inhibition of Block pathways and
protein synthesis Cell wall Cell inhibit metabolism
membrane
DNA




Ribosome Folic acid




How and Where Various Antibiotics Work
Gram Negative Gram Positive

Outer membrane


Lipoproteins

Peptidoglycan

Periplasmic
space
Cutoplasmic
membrane

Lipopolysaccharides Porin Protein


Gram + Gram + and -
Penicillins Tetracyclines Sulfonamides
(Amoxicillin) (tetracycline, doxycycline) (TMP-SMZ)
Gram + (Strep, Syphillis) Broad spectrum (Gram +/-, atypicals) UTIs
Disrupts synth of peptidoglycan Inhibit protein synth Inhibit DNA synth

Macrolides Cephalosporins Carbapenems
(azythromycin, erythromycin) Disrupts synth of peptidoglycan (meropenem)
Gram + (URI’s, Strep, Staph) 1st gen: Gram + (Keflex) Broad spectrum
Inhibits protein synth 2nd gen: Gram - > Gram + (Cefzil) Disrupts synth of peptidoglycan
3rd gen: Gram - > Gram + Pseudomonas (cefdinir)
Lincosamides (clindamycin) 4th gen: Pseudomonas (Cefepime)
Step, Staph 5th gen: MRSA (Ceftobiprole)
Inhibit protein synth
Fluoroquinolones Metronidazole
(Ciprofloxacin, Levofloxacin) (Flagyl)
Gram - Broad spectrum Anaerobes, protozoa
Disrupts DNA
Aminoglycosides Inhibit DNA synth
(streptomycin, tobramycin, gentamicin)
Gram - Psuedomonas - TB
Inhibit protein synth

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