Principles of Glomerulonephritis Practice Solution Manual Already Passed

Principles of Glomerulonephritis Practice Solution Manual Already Passed what is the process of podocyte effacement? - Answers many proteinuric diseases are characterised by loss of slit diaphragms and appearance of a continuous layer of podocyte cytoplasm what is glomerulonephritis? - Answers a term used to refer to several kidney diseases, many of which are characterised by inflammation of the glomerulus what are the 4 ways in which GN can present? - Answers AKI CKD nephritic syndrome nephrotic syndrome proliferative GN causes? - Answers nephritic syndrome non-proliferative GN causes? - Answers nephrotic syndrome the 3 types of non-proliferative GN are... - Answers minimal change disease focal and segmental glomerulosclerosis membranous GN the 4 types of proliferative GN are...? - Answers IgA nephropathy RPGN membrano-proliferative post-infectious GN what are the 3 types of RPGN? - Answers goodpastures vasculitis (wegeners granulomatosis and microscopic polyangitis) what is the most common cause of nephrotic syndrome in chiildren? - Answers minimal change GN how is minimal change disease treated? - Answers prednisolone what is the most common cause of nephrotic syndrome in adults? - Answers membranous what causes membranous GN? - Answers autoantibody attack of podocytes what is the outcome of membranous GN? - Answers 1/3 go into remission 1/3 remain in nephrotic state 1/3 progress to ESRF in which type of proliferative GN is CKD common? - Answers focal and segmental what are the causes of focal and segmental GN? - Answers primary - genetic secondary - HIV or reflux nephropathy what is the most common cause of GN worlwide? - Answers IgA nephropathy what is the typical presentation of IgA nephropathy? - Answers presents 24-48 hours after URTI what % of IgA nephropathy patients go into ESRF? - Answers 20% which type of GN can present as nephrotic syndrome and nephritic syndrome combined? - Answers membrano-proliferative what is the typical presentation of post-infectious GN? - Answers appears 2 weeks after infection - typically strep pyogenes infection which GN is characterised by c-ANCA antibodies? - Answers wegeners granulomatosis which GN is characterised by p-ANCA antibodies? - Answers microscopic polyangitis what are the clinical symptoms of Goodpasture's syndrome? - Answers Nephritic syndrome and haemoptysis what are the characteristic symptoms of nephritic syndrome? - Answers blood in urine decreased urine and hypertension proteinuria what is the primary insult in nephritic syndrome? - Answers sub-endothelial immune complex deposition what is the pathogenesis of nephritic syndrome? - Answers antibody-antigen reaction activates complement cascade - leads to congestion and glomerular capillary inflammation - causes breaks in GBM - allowing leakage of blood and protein history of Hep C should alert you to which possible cause of nephritic syndrome? - Answers cryoglobulinaemia ANA should alert you to which possible cause of nephritic syndrome? - Answers SLE ribbon pattern on immunofluorescence should alert you to which possible cause of nephritic syndrome? - Answers goodpastures