*Chr4:21338700 < -This is a Genomic Address
For each chromosome, a starting point is established-
Units are nucleotides ~2 million nucleotides into the gene ○-
DNA is a unique molecule with a unified relationship between structure and function DNA structure includes its:
chemistry ○
Subunits ○
Polarity (directionality, eg 5' 3') ○
Stoichiometry (ratio of subunits)○
1D, 2D, 3D appearance ○-
Primary Structure
The one dimensional structure of a molecule -
Cares more about the sequence rather than the appearance -
Secondary, Tertiary, Quaternary…-
DNA is a unique molecule with a unified relationship between structure and function
The structure of a molecule doesn’t immediately explain how it works -
Not the case with DNA, DNA immediately suggested how it could carry information and how it could reproduce itself -
DNA function is about information Stores information-
Maintains information-
Expresses information -
Transmitting information-
Be configured and rewritten -
Doesn’t do all of these things on its own but it creates the environment in which these things can happen Proteins bind to the major and minor groove of DNA Adenine Guanine
Thymine
Cytosine
Uracil DNA Structure: H bonds, Van der Waals, etc. Double Stranded DNA (dsDNA) Naturally takes the shape of a double helix 3 dimensional curve -
The 2 strands are held together by hydrogen bonds G and C are held by 3 bonds○
T and A are held by 2 bonds ○-
Van der Waals forces When G,T,A,C are stacked next to each other in the molecule -DNA: Overview of Structure and Function Tuesday, January 16, 2024 9:29 AM New Section 1 Page 1
For each chromosome, a starting point is established-
Units are nucleotides ~2 million nucleotides into the gene ○-
DNA is a unique molecule with a unified relationship between structure and function DNA structure includes its:
chemistry ○
Subunits ○
Polarity (directionality, eg 5' 3') ○
Stoichiometry (ratio of subunits)○
1D, 2D, 3D appearance ○-
Primary Structure
The one dimensional structure of a molecule -
Cares more about the sequence rather than the appearance -
Secondary, Tertiary, Quaternary…-
DNA is a unique molecule with a unified relationship between structure and function
The structure of a molecule doesn’t immediately explain how it works -
Not the case with DNA, DNA immediately suggested how it could carry information and how it could reproduce itself -
DNA function is about information Stores information-
Maintains information-
Expresses information -
Transmitting information-
Be configured and rewritten -
Doesn’t do all of these things on its own but it creates the environment in which these things can happen Proteins bind to the major and minor groove of DNA Adenine Guanine
Thymine
Cytosine
Uracil DNA Structure: H bonds, Van der Waals, etc. Double Stranded DNA (dsDNA) Naturally takes the shape of a double helix 3 dimensional curve -
The 2 strands are held together by hydrogen bonds G and C are held by 3 bonds○
T and A are held by 2 bonds ○-
Van der Waals forces When G,T,A,C are stacked next to each other in the molecule -DNA: Overview of Structure and Function Tuesday, January 16, 2024 9:29 AM New Section 1 Page 1
