TESTBANK FOR CLAYTONS BASIC PHARMACOLOGY FOR
NURSES 18TH EDITION 48CHAPTERS BY WILLIHNGANZ
Chapter 1: Basic Principles of Drug Action and Drug
Interactions Test Bank
MULTIPLE CHOICE
1. The nurse assesses hives in a patient started on a new medication. What is
the nurse’s priority action?
a. Notify physician of allergic reaction.
b. Notify physician of idiosyncratic reaction.
c. Notify physician of potential teratogenicity.
d. Notify physician of potential tolerance.
ANS: A
An allergic reaction is indicative of hypersensitivity and manifests with
hives and/or urticaria, which are easily identified. An idiosyncratic reaction
occurs when something unusual or abnormal happens when a drug is first
administered. A teratogenic reaction refers to the occurrence of birth
defects related to administration of the drug. Tolerance refers to the body’s
requirement for increasing dosages to achieve the same effects that a lower
dose once did.
TEST
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DIF: Cognitive Level: Application REF:
p. 17 OBJ: 7 TOP: Nursing Process Step: Assessment
MSC: NCLEX Client Needs Category: Physiological Integrity
2. The nurse administers an initial dose of a steroid to a patient with asthma.
Thirty minutes after administration, the nurse finds the patient agitated
and stating that “everyone is out to get me.” What is the term for this
unusual reaction?
a. Desired action
b. Adverse effect
c. Idiosyncratic reaction
d. Allergic reaction
ANS: C
Idiosyncratic reactions are unusual, abnormal reactions that occur when a
drug is first administered. Patients typically exhibit an overresponsiveness
to a medication related to diminished metabolism. These reactions are
believed to be related to genetic enzyme deficiencies. Desired actions are
expected responses to a medication. Adverse effects are reactions that
occur in another system of the body; they are usually predictable. Allergic
reactions appear after repeated medication dosages.
DIF: Cognitive Level: Comprehension REF:
p. 17 OBJ: 7 TOP: Nursing Process Step: Evaluation
MSC: NCLEX Client Needs Category: Physiological Integrity
3. Which is the best description of when drug interactions occur?
a. On administration of toxic dosages of a drug
b. On an increase in the pharmacodynamics of bound drugs
c. On the alteration of the effect of one drug by another drug
d. On increase of drug excretion
TEST
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ANS: C
TEST
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Drug interactions may be characterized by an increase or decrease in the
effectiveness of one or both of the drugs. Toxicity of one drug may or may
not affect the metabolism of another one. Drug interactions may result
from either increased or decreased pharmacodynamics.
Drug interactions may result from either increased or decreased excretion.
DIF: Cognitive Level: Comprehension REF:
p. 17 OBJ: 8 TOP: Nursing Process Step: Assessment
MSC: NCLEX Client Needs Category: Physiological Integrity
4. What occurs when two drugs compete for the same receptor site,
resulting in increased activity of the first drug?
a. Desired action
b. Synergistic effect
c. Carcinogenicity
d. Displacement
ANS: D
The displacement of the first drug from receptor sites by a second drug
increases the amount of the first drug because more unbound drug is
available. An expected response of a drug is the desired action. A
synergistic effect is the effect of two drugs being greater than the effect of
each chemical individually, or the sum of the individual effects.
Carcinogenicity is the ability of a drug to cause cells to mutate and
become cancerous.
DIF: Cognitive Level: Comprehension REF:
p. 17 OBJ: 9 TOP: Nursing Process Step:
Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
5. What do drug blood levels indicate?
TEST
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