BMTCN Test B questions with correct answers

Transplant-related toxicity is a barrier that contributes to the underutilization for which of the following diseases? A. Non-Hodgkin lymphoma B. Acute myeloid leukemia C. Sickle cell disease D. Neuroblastoma CORRECT ANSWER C. Sickle cell disease Despite success of HSCT in sickle cell disease, barriers to successful HSCT include lack of a suitable donor, transplant related toxicity and immunologic graft rejection. Which of the following is a chemokine receptor that helps to regulate stem cell release into the peripheral circulation? A. CXCR4 B. CD34 C. CD14 D. CCR7 CORRECT ANSWER A. CXCR4 CXCR4 has been identified as being important in the regulation of trafficking and homing of cells involved in hematopoiesis and the immune system. Which of the following is a disadvantage of a syngeneic transplant? A. Prolonged immunosuppression is required B. Limited supply of stem cells C. Longer time to engraftment