1~ 1oc1~~le. 3g
i3 :J
9
0 \-If fl 5pec.i(i C Ee\ Sele c.t.1V j
P; <Yt.e.i r,3 ooC\ _:)ie.Ld
L~no U,CSte..fuL ~-pro du ct.5 .
o A c.l:.i'le .Site.-=:,wr--ere subsaa1::e bind s .
"20 st.C\nc\arc\ -b.
° Cnirol
,'.:JP2-5 ,o cu e e$~nt 1CI
L
o l.o<:J( 4, \(.~ nr,oc:\el.r-' eocn
. ·--= re, ,-
en~:r"'
-pe<
e t-,a5
itlC.
C\ 5p€ci 1(_ CI C-1:.1-le_ c,lu_ "t<
0
2. f'or rn:s D-i.sorners -">l"Ot in poteil\5 substrate.:5 . ---, , orrec.~ Si 't.e lt 5 kape ,
- , L - isomers o (L-,d ... cec.\ ht cho0 e.5
5\-,c,pe tD +le 5..,'\":,51:..rc::,t.e .
9 AA - cs are nol'-pol.or - -:, ::Jclrophobic
0 11 AA - 5 ore. h d . . 1...-,scck ~rophcbi< <>1-\c,,.ti ctoes on e".'.:'.)rr-e tou,;,e.-- E" 7
: ; roph 1LIC. et'l-. l ron S
r 1.-,~ . inter ior ol ff't2111brONt,
t
or·, ento-1:..ion
1...-, l r .
a p ot~" .s&Kroc:e . '?ta" ourable e nv iron t"lent
0 :, 'oencli':5 .sub.st.rot:.e.. \:.o tac:i Li t.ote
Bone\ between AA - s--:, peptide l:xf'd
t::otxl-br e.alr,i'.j
Le-.eL5 of Or:_J'"\:sct\or,g
0
P r i mo_'.) _., AA sec~ue r>ce_
\le.::! Low
r't
c
-'")Cc rn lel\ t p~1de \:onc\5
·1nC\C tise. \::,u.t ur<\orn,a9ec\ ·
4Cl"Ol a t1,u,c.\\oni~ protein .
L·,t.-1:.l.<2 contac t g s'to'..., rno" i'.:j
c S eco ncla
0 -") Fold~ ir>to c,(.-\.eli-.:x.., B·.shee.t. o r co ll _
-") hjclr.'.'.:J" oon cl.s between AA-s
"5Lou., re.octior- rate. .
c Tert\ e1
0 --,
-=J
30 Fold·, "9 of" pol.i..jpep!:-i e\e .
ci
0. °'6'ond5 , tli5Ui:phi de t:x::Nt5 ,e.Lect re.st.a lie
~el<
1nte, Cl Ct IOI\°::,
" Ouacer~ -") Assoc tobor. of t <.VO or r(X)r-e. F.J pieptldes
-lo form a 1117ult.l-me.ric pr-otein .
~naturi2) of' P rc teif\'3g
uNIU'ect.ed .
Olcss of' h h e. r oH:\er Structure _., AA·~
0
o Ca use5
r, \:::::Ctreme.s of 1""2.at
L E::c..tr-erne.s cl' pk
'J Cl,,emic.a\S
r'rot~i l' Str ucture g
c, 3D Struc t ure c\ic.totecl ~ 'l
~
t n terac-t.io n wit\-. .solve nt r<"O l ecule s
pl-\ a ionic. co~ 5 1t.1 0 1"\ o f .SOllld\t
?:Jm esg
r .-o t eif"\ sequ e rce .
_-, .,.aO
l(m C..5)
Ent)=
0:, 1:ou.ist:.s -=:i ~ ci u p r eoc:t.ion.s ....,,thout be.j Cl
Assd g
U:si '::) spect 1o p\"\oc.o rne h Lj , o
0
re.cid:·-tint . -=>'treoct:ion rcrt.e. . 0
o Llou:.e.rS r~ac.t C1nt-s ac.-li'lot.ior, e.r-e.~j t.\--e.Cho ~ t\-.ot \"\a S 1::.a-ifen pl-CICe a t.
=,Lt.>i t:hOUt en~ <re.
a 5pec.+i c... UJO\Jele c.h .
C'...t lE<l li r.ei,Wc0~e.r -13u rk \'lotg
0
J...
B , .L
" \J
Km
= \IITC\X: CS] T
I \Jo
l!.J
"
C:
C)~~
/<\_.l.- -~
,, ,, ~<""1
i3 :J
9
0 \-If fl 5pec.i(i C Ee\ Sele c.t.1V j
P; <Yt.e.i r,3 ooC\ _:)ie.Ld
L~no U,CSte..fuL ~-pro du ct.5 .
o A c.l:.i'le .Site.-=:,wr--ere subsaa1::e bind s .
"20 st.C\nc\arc\ -b.
° Cnirol
,'.:JP2-5 ,o cu e e$~nt 1CI
L
o l.o<:J( 4, \(.~ nr,oc:\el.r-' eocn
. ·--= re, ,-
en~:r"'
-pe<
e t-,a5
itlC.
C\ 5p€ci 1(_ CI C-1:.1-le_ c,lu_ "t<
0
2. f'or rn:s D-i.sorners -">l"Ot in poteil\5 substrate.:5 . ---, , orrec.~ Si 't.e lt 5 kape ,
- , L - isomers o (L-,d ... cec.\ ht cho0 e.5
5\-,c,pe tD +le 5..,'\":,51:..rc::,t.e .
9 AA - cs are nol'-pol.or - -:, ::Jclrophobic
0 11 AA - 5 ore. h d . . 1...-,scck ~rophcbi< <>1-\c,,.ti ctoes on e".'.:'.)rr-e tou,;,e.-- E" 7
: ; roph 1LIC. et'l-. l ron S
r 1.-,~ . inter ior ol ff't2111brONt,
t
or·, ento-1:..ion
1...-, l r .
a p ot~" .s&Kroc:e . '?ta" ourable e nv iron t"lent
0 :, 'oencli':5 .sub.st.rot:.e.. \:.o tac:i Li t.ote
Bone\ between AA - s--:, peptide l:xf'd
t::otxl-br e.alr,i'.j
Le-.eL5 of Or:_J'"\:sct\or,g
0
P r i mo_'.) _., AA sec~ue r>ce_
\le.::! Low
r't
c
-'")Cc rn lel\ t p~1de \:onc\5
·1nC\C tise. \::,u.t ur<\orn,a9ec\ ·
4Cl"Ol a t1,u,c.\\oni~ protein .
L·,t.-1:.l.<2 contac t g s'to'..., rno" i'.:j
c S eco ncla
0 -") Fold~ ir>to c,(.-\.eli-.:x.., B·.shee.t. o r co ll _
-") hjclr.'.'.:J" oon cl.s between AA-s
"5Lou., re.octior- rate. .
c Tert\ e1
0 --,
-=J
30 Fold·, "9 of" pol.i..jpep!:-i e\e .
ci
0. °'6'ond5 , tli5Ui:phi de t:x::Nt5 ,e.Lect re.st.a lie
~el<
1nte, Cl Ct IOI\°::,
" Ouacer~ -") Assoc tobor. of t <.VO or r(X)r-e. F.J pieptldes
-lo form a 1117ult.l-me.ric pr-otein .
~naturi2) of' P rc teif\'3g
uNIU'ect.ed .
Olcss of' h h e. r oH:\er Structure _., AA·~
0
o Ca use5
r, \:::::Ctreme.s of 1""2.at
L E::c..tr-erne.s cl' pk
'J Cl,,emic.a\S
r'rot~i l' Str ucture g
c, 3D Struc t ure c\ic.totecl ~ 'l
~
t n terac-t.io n wit\-. .solve nt r<"O l ecule s
pl-\ a ionic. co~ 5 1t.1 0 1"\ o f .SOllld\t
?:Jm esg
r .-o t eif"\ sequ e rce .
_-, .,.aO
l(m C..5)
Ent)=
0:, 1:ou.ist:.s -=:i ~ ci u p r eoc:t.ion.s ....,,thout be.j Cl
Assd g
U:si '::) spect 1o p\"\oc.o rne h Lj , o
0
re.cid:·-tint . -=>'treoct:ion rcrt.e. . 0
o Llou:.e.rS r~ac.t C1nt-s ac.-li'lot.ior, e.r-e.~j t.\--e.Cho ~ t\-.ot \"\a S 1::.a-ifen pl-CICe a t.
=,Lt.>i t:hOUt en~ <re.
a 5pec.+i c... UJO\Jele c.h .
C'...t lE<l li r.ei,Wc0~e.r -13u rk \'lotg
0
J...
B , .L
" \J
Km
= \IITC\X: CS] T
I \Jo
l!.J
"
C:
C)~~
/<\_.l.- -~
,, ,, ~<""1
