Summary NR566 Week 2 Study Outline

NR566 Week 2 Study Outline NR566 Week 2 Study Outline Chapter 17: Drugs Affecting the Respiratory System Bronchodilators: Beta 2 Receptor Agonists (B2RA): Short and long acting beta agonists • B2RA widely used in all ages to treat reversible bronchoconstriction caused by reactive airway disease (RAD) or COPD • Bronchodilators • Short-acting beta agonists: Albuterol (ProAir, Ventolin, Proventil) , metaproterenol (Alupent), terbutaline (Brethine, Brethaire), bitolterol (Tornalate), pirbuterol (Maxair), and levalbuterol (Xopenex) • Long-acting beta agonists: arformoterol (Brovana), salmeterol (Serevent), formoterol (Foradil), and indacaterol (Arcapta Neohaler) • Drug of choice during pregnancy for asthma Pharmacodynamics • Act on smooth muscle to reverse bronchospasm, decreases airway resistance and residual volume and increasing VC and airflow • Stimulate beta 2 adrenergic receptors in the lungs to increase cAMP production which relaxes bronchial smooth muscle and inhibits mediators from hypersensitivity cells (mast cells) • All beta agonists stimulate beta 1 activity (increased HR, tremor)f Short Acting Beta Agonists • Albuterol o Selective beta2 agonist with minor beta1