Harrison-Based Nursing MCQ Study Guide & Practice Test Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics



1. A 68-year-old patient with multiple chronic illnesses
expresses interest in stopping one of several medications.
Which step best reflects the clinician’s first responsibility
when considering deprescribing?
A. Immediately stop the medication with the most side
effects.
B. Review the patient’s goals of care, life expectancy, and
current medication benefits/harms.
C. Transfer all medications to a pill organizer and continue.
D. Substitute all prescription drugs with over-the-counter
alternatives.
Answer: B
Rationale: Safe deprescribing begins with assessing the
patient’s goals, prognosis, and the balance of benefits versus
harms for each medication. This is central to individualized care
planning.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 1: The Practice of Medicine.

, 2. Which primary prevention intervention is most effective
population-wide for reducing cardiovascular disease risk?
A. Routine chest radiography for all adults.
B. Counseling and policies that reduce tobacco use.
C. Annual echocardiograms starting at age 40.
D. Universal aspirin for adults over 50.
Answer: B
Rationale: Population-level tobacco control (policy and
counseling) produces the largest reduction in cardiovascular
risk; other choices are either inappropriate or unsupported as
universal measures.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 2: Promoting Good Health.


3. A parent refuses routine childhood vaccines for their
toddler due to safety concerns. As the nurse, which
approach is highest-yield to address vaccine hesitancy?
A. Provide a detailed lecture on immunology.
B. Use a presumptive recommendation and address
specific concerns empathetically.
C. Threaten to report the parent to authorities.
D. Tell them to research online and return later.
Answer: B
Rationale: A presumptive recommendation from clinicians
combined with empathetic, targeted responses to concerns is
more effective at increasing uptake than confrontation or

, nonengagement.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 3: Vaccine Opposition and Hesitancy.


4. A clinic must decide whether to adopt a new diagnostic
test that slightly increases sensitivity but substantially
increases false positives. Using decision-analysis principles,
which factor should most influence adoption?
A. Cost of the test alone.
B. How false positives affect downstream patient harm and
resource use.
C. Popularity of the test on social media.
D. Whether the test requires specialist training.
Answer: B
Rationale: Decision-making requires evaluating not just test
accuracy but the clinical consequences of false positives
(patient harm, unnecessary procedures, resource burden).
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 4: Decision-Making in Clinical Medicine.


5. A patient’s tumor is found to carry a specific actionable
mutation. Which nursing implication follows from
knowledge of precision medicine?
A. All cancer therapies are now replaced by mutation-
based drugs.