Molecular Genetics and Development

The University of York (UOY)

Here are the best resources to pass Molecular Genetics and Development. Find Molecular Genetics and Development study guides, notes, assignments, and much more.

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15. Genomic Imprinting 15. Genomic Imprinting
  • 15. Genomic Imprinting

  • Class notes • 8 pages • 2020
  • - To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise - Describe key events in X-inactivation including the role of the Xist non-coding RNA
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10. Germ Layer Specification 10. Germ Layer Specification
  • 10. Germ Layer Specification

  • Class notes • 8 pages • 2020
  • - Discuss the evidence for the nodal morphogen acting during mesoderm induction. - Discuss the concept of the vertebrate dorsal organiser. - Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification. - Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
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13. Histone Modifications 13. Histone Modifications
  • 13. Histone Modifications

  • Class notes • 9 pages • 2020
  • - Provide an overview of the polycomb and trithorax group complexes and their activities - Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state - Understand what is bivalent chromatin and why it may be important for stem cell biology and development - Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies - Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
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2. Homeotic Genes 2. Homeotic Genes
  • 2. Homeotic Genes

  • Class notes • 8 pages • 2020
  • - Describe experiments that defined compartments of cell lineage restriction. - Define a compartment and describe the evidence showing that the parasegment is a compartment and the developmentally important unit of the fly. - Describe genetic experiments demonstrating that HOM-C genes regulate parasegment identity in Drosophila. - Evaluate whether the vertebrate Hox genes share a conserved function with Drosophila HomC genes
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7. Induction Migration of Neural Crest 7. Induction Migration of Neural Crest
  • 7. Induction Migration of Neural Crest

  • Class notes • 7 pages • 2020
  • - Explain the significance of the neural crest lineage to vertebrate anatomy. - Distinguish the ventral-lateral and dorsal pathways of neural crest migration. - Give examples of cell types derived from specific AP regions of neural crest. - Describe and interpret experiments used to ‘fate map’ neural crest cells in avian embryos. - Describe and interpret experiments used to determine the developmental potential of neural crest cells in avian embryos.
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6. Limb Development 6. Limb Development
  • 6. Limb Development

  • Class notes • 7 pages • 2020
  • - Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance. - Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth - Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud. - Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
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3. Neural Induction 3. Neural Induction
  • 3. Neural Induction

  • Class notes • 6 pages • 2020
  • - Appreciate and describe the molecular mechanisms underlying neural induction - Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways - Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction - Describe how antisense morpholino oligos can be used to inhibit gene function - Appreciate and describe the differences between the processes of neural induction versus neurogenesis
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5. Patterning Neural Tube 5. Patterning Neural Tube
  • 5. Patterning Neural Tube

  • Class notes • 7 pages • 2020
  • -Describe and interpret the embryological experiments that demonstrated a role for the notochord and floorplate in motor neuron induction. -Describe and interpret the experiments that show Shh acts as a morphogen to pattern the ventral neural tube. -Be able to explain the concept of morphogen using examples. -Describe the Shh signal transduction pathway.
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1. Segmentation Genes 1. Segmentation Genes
  • 1. Segmentation Genes

  • Class notes • 7 pages • 2020
  • -Describe the hierarchy of gene activity that regulates Drosophila segmentation -Distinguish and explain methods used to investigate protein vs mRNA expression -Describe the syncytial nature of the early stages of fly development and understand its significance. -Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2 -Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
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11. Small Changes Big Differences 11. Small Changes Big Differences
  • 11. Small Changes Big Differences

  • Class notes • 10 pages • 2020
  • - Understand how the neural crest contributes to cardiac development and the pathology underlying congenital cardiac abnormalities. - Explain how certain SNPs might contribute to congenital abnormalities. - Discuss the evidence that Notch signalling is important during cardiac morphogenesis
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