Clinical Medicine III (CM3) – GI Cancer Q&A (15 Questions) | 2025 | Esophageal, Colorectal & Pancreatic Indicators

This concise, exam-focused document offers 15 high-yield questions and verified answers on gastrointestinal cancers, part of the Clinical Medicine III (CM3) curriculum. The questions cover critical diagnostic, pathological, and clinical features of esophageal adenocarcinoma, colorectal cancer, and pancreatic cancer. Key topics include the progression from regurgitation to Barrett’s esophagus, the use of endoscopy and biopsy for diagnosis, and the role of CT imaging in staging esophageal cancer. Important anatomical knowledge is reinforced, such as the common location of adenocarcinoma at the distal esophagus and colorectal cancers near the rectum and splenic flexure. The document also includes hallmark clinical signs of pancreatic cancer like Courvoisier’s sign and Trousseau’s sign, providing key board-style clinical correlations. Best suited for medical students, nursing students, PA programs, and learners preparing for GI system exams, OSCEs, or clinical oncology rotations. Keywords: esophageal adenocarcinoma, Barrett’s esophagus, endoscopy, GI biopsy, colorectal cancer, colonoscopy, distal colon tumors, Courvoisier’s sign, Trousseau’s sign, pancreatic cancer, CT scan staging, squamocolumnar junction, gastroesophageal reflux, GI oncology