Clinical Medicine III (CM3) – GI, Hepatobiliary & Pancreas Q&A (100+ Questions) | 2025 | IBD, GERD, PUD, Cancer, Cholecystitis

This advanced and detailed exam preparation document presents 100+ expertly answered questions from the Clinical Medicine III (CM3) course, focusing on gastrointestinal, hepatobiliary, and pancreatic systems. It spans a broad spectrum of high-yield topics, including acid secretion physiology, gastric hormones (gastrin, somatostatin, histamine, ACh), and major conditions like peptic ulcer disease (PUD), GERD, and Barrett’s esophagus. The document further explores gastric and esophageal carcinoma, colorectal cancer, pancreatic cancer, and their diagnostic hallmarks (e.g., Courvoisier's sign, Trousseau’s sign). It contains in-depth comparisons between Crohn’s disease and ulcerative colitis (UC)—including lesion patterns, complications, and endoscopic findings—and also addresses cholelithiasis, cholecystitis, choledocholithiasis, cholangitis, and Mirizzi syndrome, along with appropriate imaging and treatment options. The final section covers acute pancreatitis, with distinctions between interstitial and necrotizing forms, key clinical signs (Cullen’s and Grey-Turner), and enzymatic markers (e.g., serum lipase). This resource is ideal for medical students, nursing students, and physician associate/assistant programs reviewing for GI blocks, clinical exams, rotations, and board prep. Keywords: peptic ulcer disease, GERD, gastrin, H. pylori, Barrett’s esophagus, colorectal cancer, pancreatic cancer, Crohn’s disease, ulcerative colitis, cholelithiasis, cholecystitis, choledocholithiasis, cholangitis, pancreatitis, Cullen's sign, Grey Turner sign, Whipple, bile salts, hepatobiliary disease, GI cancers