NURS 5334 Advanced Pharm Exam 2
Questions and Answers Latest update 2025
100% Correct
A 12-year-old child has extensive psoriatic lesions covering his back. Which topical
therapy applied with continuous use has the potential to prevent him from reaching
his full adult height?
Salicylic acid
Clobetasol propionate
Calcipotriene
Calcitriol - **Answer** Clobetasol propionate
Excessive use of potent corticosteroids applied to a large surface area can cause
systemic adverse effects, including growth retardation.
A 32-year-old woman with papulopustular rosacea prefers to use a topical agent,
rather than an oral agent, to treat her lesions. Which of the following agents is the
most appropriate recommendation?
Brimonidine
Doxycycline
Oxymetazoline
Metronidazole - **Answer** Metronidazole is an antibacterial agent used topically
for papulopustular rosacea. It is believed to work in rosacea through anti-
inflammatory or immunosuppressive effects. Doxycycline is also used for
,papulopustular rosacea but is used orally rather than topically. Brimonidine and
oxymetazoline are topical agents but are used for erythematotelangiectatic rosacea.
A 26-year-old woman with pustular psoriasis would like to become pregnant and
start a family within the next two years. Which agent should be avoided for treatment
of her psoriasis because the duration of its teratogenic potential may affect her plans
for pregnancy?
Triamcinolone acetonide
Infliximab
Acitretin
Calcipotriene - **Answer** Acitretin is teratogenic, and women must avoid
pregnancy for at least 3 years after the use of this drug (due to the long duration of
teratogenic potential).
Which of the following agents is used as a repigmentation agent for patients with
vitiligo that must be photoactivated by UV radiation to form a DNA adduct inhibiting
DNA replication by psoralen plus UVA radiation?
Methoxsalen
Tazarotene
,Hydroquinone
Adapalene - **Answer** Methoxsalen: Methoxsalen is a psoralen photoactive agent
that stimulates melanocytes and is used as a repigmentation agent for patients with
vitiligo (Figure 43.7). It must be photoactivated by UV radiation to form a DNA
adduct inhibiting DNA replication by a method called PUVA (psoralen plus UVA
radiation)
A 33-year-old man wants to quickly get his plaque psoriasis in visible areas under
control for a planned trip to Jamaica and wants to keep it under control for at least
the remainder of the summer. Which of the following therapeutic strategies for
psoriasis would best enable the patient to achieve his goals?
Combination therapy
Step-up therapy
Monotherapy
Sequential therapy - **Answer** Sequential therapy would likely be the best
approach, as stronger and sometimes more toxic agents are used initially to rapidly
clear the lesions, followed by less toxic agents for maintenance therapy.
A 45-year-old woman burned her hand while cooking dinner. Her skin blistered from
the burn, and now the burned area is open. Which of the following topical
, medications is most appropriate to recommend to the patient for prevention of skin
infection after a burn?
Retapamulin
Bacitracin/polymyxin
Ozenoxacin
Mupirocin - **Answer** Bacitracin/polymyxin
This combination ointment containing both bacitracin and polymyxin is mostly used
for the prevention of skin infections after burns or minor scrapes.
A patient has been using topical minoxidil to manage his baldness for several years,
but now wants to stop using the medication. What is the likely consequence of
discontinuing this medication?
Hair growth will be maintained.
Hair color will start to turn gray.
Blood pressure will increase.
Hair loss will resume. - **Answer** Hair loss will resume.
Rationale:Topical minoxidil must be used continuously to maintain effects on hair
growth. Minoxidil does not affect hair color, and topical minoxidil does not affect
blood pressure.
Questions and Answers Latest update 2025
100% Correct
A 12-year-old child has extensive psoriatic lesions covering his back. Which topical
therapy applied with continuous use has the potential to prevent him from reaching
his full adult height?
Salicylic acid
Clobetasol propionate
Calcipotriene
Calcitriol - **Answer** Clobetasol propionate
Excessive use of potent corticosteroids applied to a large surface area can cause
systemic adverse effects, including growth retardation.
A 32-year-old woman with papulopustular rosacea prefers to use a topical agent,
rather than an oral agent, to treat her lesions. Which of the following agents is the
most appropriate recommendation?
Brimonidine
Doxycycline
Oxymetazoline
Metronidazole - **Answer** Metronidazole is an antibacterial agent used topically
for papulopustular rosacea. It is believed to work in rosacea through anti-
inflammatory or immunosuppressive effects. Doxycycline is also used for
,papulopustular rosacea but is used orally rather than topically. Brimonidine and
oxymetazoline are topical agents but are used for erythematotelangiectatic rosacea.
A 26-year-old woman with pustular psoriasis would like to become pregnant and
start a family within the next two years. Which agent should be avoided for treatment
of her psoriasis because the duration of its teratogenic potential may affect her plans
for pregnancy?
Triamcinolone acetonide
Infliximab
Acitretin
Calcipotriene - **Answer** Acitretin is teratogenic, and women must avoid
pregnancy for at least 3 years after the use of this drug (due to the long duration of
teratogenic potential).
Which of the following agents is used as a repigmentation agent for patients with
vitiligo that must be photoactivated by UV radiation to form a DNA adduct inhibiting
DNA replication by psoralen plus UVA radiation?
Methoxsalen
Tazarotene
,Hydroquinone
Adapalene - **Answer** Methoxsalen: Methoxsalen is a psoralen photoactive agent
that stimulates melanocytes and is used as a repigmentation agent for patients with
vitiligo (Figure 43.7). It must be photoactivated by UV radiation to form a DNA
adduct inhibiting DNA replication by a method called PUVA (psoralen plus UVA
radiation)
A 33-year-old man wants to quickly get his plaque psoriasis in visible areas under
control for a planned trip to Jamaica and wants to keep it under control for at least
the remainder of the summer. Which of the following therapeutic strategies for
psoriasis would best enable the patient to achieve his goals?
Combination therapy
Step-up therapy
Monotherapy
Sequential therapy - **Answer** Sequential therapy would likely be the best
approach, as stronger and sometimes more toxic agents are used initially to rapidly
clear the lesions, followed by less toxic agents for maintenance therapy.
A 45-year-old woman burned her hand while cooking dinner. Her skin blistered from
the burn, and now the burned area is open. Which of the following topical
, medications is most appropriate to recommend to the patient for prevention of skin
infection after a burn?
Retapamulin
Bacitracin/polymyxin
Ozenoxacin
Mupirocin - **Answer** Bacitracin/polymyxin
This combination ointment containing both bacitracin and polymyxin is mostly used
for the prevention of skin infections after burns or minor scrapes.
A patient has been using topical minoxidil to manage his baldness for several years,
but now wants to stop using the medication. What is the likely consequence of
discontinuing this medication?
Hair growth will be maintained.
Hair color will start to turn gray.
Blood pressure will increase.
Hair loss will resume. - **Answer** Hair loss will resume.
Rationale:Topical minoxidil must be used continuously to maintain effects on hair
growth. Minoxidil does not affect hair color, and topical minoxidil does not affect
blood pressure.
