MSK & Neuro Rapid Path – 2025 | Exam Q&A (100+) | Glioblastoma, MS, Ewing Sarcoma, ALS, Ataxia, Brain Tumors

This document offers a high-yield collection of over 100 rapid-style exam questions and verified answers focused on musculoskeletal and neurological pathology, curated for the 2025 academic cycle. Structured in an accelerated Q&A format, this resource is ideal for students preparing for board exams such as USMLE Step 1/2, COMLEX, or in-course pathology evaluations. It covers essential neurodegenerative diseases, CNS tumors, bone tumors, and congenital disorders with both clinical presentations and histopathologic findings. Neurological content includes autoimmune demyelinating disorders like Multiple Sclerosis and Guillain-Barré syndrome, CNS infections (PML), hydrocephalus types, and cerebrovascular accidents. Brain tumors are reviewed in-depth: Glioblastoma, Medulloblastoma, Schwannoma, Meningioma, and Craniopharyngioma—with associated symptoms, histology, and locations. Movement disorders like Huntington’s and Parkinson’s diseases are explained through genetic mechanisms and anatomical degeneration. The MSK pathology section highlights bone tumors such as Ewing Sarcoma, Osteosarcoma, Chondrosarcoma, Giant Cell Tumor, and Enchondroma. Each entry includes key diagnostic features, gene mutations, and radiologic clues. Degenerative and inherited neuromuscular diseases like ALS, Spinal Muscular Atrophy, and Friedreich Ataxia are presented with distinguishing clinical signs. Pediatric cases such as Cerebral Palsy and Congenital Hypothyroidism are also reviewed. Recommended for: Medical students (MD/DO) Physician assistant (PA) students Nursing and physical therapy students in neuro/MSK rotations USMLE Step 1 & Step 2 CK, COMLEX Level 1, PANCE prep Students studying neuroanatomy, pathology, or pediatrics Keywords: glioblastoma, multiple sclerosis, medulloblastoma, schwannoma, meningioma, craniopharyngioma, guillain-barre, ALS, huntington disease, parkinson disease, ewing sarcoma, osteosarcoma, chondrosarcoma, enchondroma, giant cell tumor, SMA, Werdnig-Hoffman, friedreich ataxia, cerebral palsy, congenital hypothyroidism, neuro pathology, MSK pathology