NURS 5315: Advanced Patho ACTUAL Exam 2 TEST
BANK NEWEST VERSION COMPLETE QUESTIONS AND
CORRECT DETAILED ANSWERS WITH
RATIONALES|ALREADY GRADED A+ (The University of Texas
at Arlington )
Prostaglandin of arachidonic pathway. Provides
COX1
gastroprotection, platelet aggregation,
fluid/electrolyte balance
Prostaglandin of arachidonic pathway. Responsible for
COX2
pain, fever, renal protection, tissue repair,
reproduction development.
Protect gastric mucosa- prevent ulcers and bleeding.
COX2 inhibitors- clinical
implications Removed from market r/t cardiac events except for
Celebrex. Can impair renal function , monitor labs.
Arachidonic pathway purpose Synthesis of prostaglandins
Inhibit COX1 and COX2, risk for gastric ulceration, GI
Non-selective NSAIDS
bleeds, edema, renal impairment
ASA Blocks COX1 and COX2, also inhibits Thromboxane A2 and
prostaglandins
Inhibit phospholipase A2, preventing formation of
Corticosteroids
prostaglandins, thromboxane A2, prostacyclin, and
leukotrines
Thromboxane Vasoconstriction, platelet aggregation
Prostacyclin Vasodilation, platelet aggregation (most effective one)
E. Immediate response to allergen, food, meds, pollen, asthma,
allergic reactions
Type 1 hypersensitivity P. IgE binds with antigen at 1st exposure. Antigen binds
with this complex at 2nd exposure. Inflammatory
cascade initiates.
C.M. Urticaria, rhinitis, conjunctivitis, angioedema, anaphylaxis
Atopic disorders Genetic Type 1 hypersensitivity, asthma, hay fever, eczema,
urticaria
E. Antibodies directed against fixed antigens on the plasma
Type 2 hypersensitivity
membrane of cells
, C.M. Varies depending on alloimmune or autoimmune
When an individuals immune system reacts against
antigens on the tissues of other members of the same
Alloimmunity and example of species
hypersensitivity Blood transfusions- causes clumping and lysis of RBC-
fever, nausea, chills, low back pain, dark urine, hives,
itching, SOB
Rh incompatibility- hemolytic disease of newborn with
jaundice, give Rhogam within 72 hours of birth (Rh-
mother with Rh+ child)
A breakdown of tolerance in which the bodies immune
system begins to recognize self-antigens as foreign.
Graves Disease- autoantibodies form against thyroid
cells- bind to thyroid cells and mimic action of TSH,
Autoimmunity and example of increases secretion of thyroxine
hypersensitivity Myasthenia Gravis- autoantibodies against acetylcholine
bind to the post synaptic receptors and inhibit synaptic
transmission of acetylcholine. Leads to muscle
weakness and paralysis (mind to ground)
Guillain-Barre' syndrome- antibodies bind with myelin
sheath of the peripheral nervous system, triggering the
immune response. Causes demyelination of the
peripheral nerves and a rapidly progressive, ascending
paralysis (ground to brain)
BANK NEWEST VERSION COMPLETE QUESTIONS AND
CORRECT DETAILED ANSWERS WITH
RATIONALES|ALREADY GRADED A+ (The University of Texas
at Arlington )
Prostaglandin of arachidonic pathway. Provides
COX1
gastroprotection, platelet aggregation,
fluid/electrolyte balance
Prostaglandin of arachidonic pathway. Responsible for
COX2
pain, fever, renal protection, tissue repair,
reproduction development.
Protect gastric mucosa- prevent ulcers and bleeding.
COX2 inhibitors- clinical
implications Removed from market r/t cardiac events except for
Celebrex. Can impair renal function , monitor labs.
Arachidonic pathway purpose Synthesis of prostaglandins
Inhibit COX1 and COX2, risk for gastric ulceration, GI
Non-selective NSAIDS
bleeds, edema, renal impairment
ASA Blocks COX1 and COX2, also inhibits Thromboxane A2 and
prostaglandins
Inhibit phospholipase A2, preventing formation of
Corticosteroids
prostaglandins, thromboxane A2, prostacyclin, and
leukotrines
Thromboxane Vasoconstriction, platelet aggregation
Prostacyclin Vasodilation, platelet aggregation (most effective one)
E. Immediate response to allergen, food, meds, pollen, asthma,
allergic reactions
Type 1 hypersensitivity P. IgE binds with antigen at 1st exposure. Antigen binds
with this complex at 2nd exposure. Inflammatory
cascade initiates.
C.M. Urticaria, rhinitis, conjunctivitis, angioedema, anaphylaxis
Atopic disorders Genetic Type 1 hypersensitivity, asthma, hay fever, eczema,
urticaria
E. Antibodies directed against fixed antigens on the plasma
Type 2 hypersensitivity
membrane of cells
, C.M. Varies depending on alloimmune or autoimmune
When an individuals immune system reacts against
antigens on the tissues of other members of the same
Alloimmunity and example of species
hypersensitivity Blood transfusions- causes clumping and lysis of RBC-
fever, nausea, chills, low back pain, dark urine, hives,
itching, SOB
Rh incompatibility- hemolytic disease of newborn with
jaundice, give Rhogam within 72 hours of birth (Rh-
mother with Rh+ child)
A breakdown of tolerance in which the bodies immune
system begins to recognize self-antigens as foreign.
Graves Disease- autoantibodies form against thyroid
cells- bind to thyroid cells and mimic action of TSH,
Autoimmunity and example of increases secretion of thyroxine
hypersensitivity Myasthenia Gravis- autoantibodies against acetylcholine
bind to the post synaptic receptors and inhibit synaptic
transmission of acetylcholine. Leads to muscle
weakness and paralysis (mind to ground)
Guillain-Barre' syndrome- antibodies bind with myelin
sheath of the peripheral nervous system, triggering the
immune response. Causes demyelination of the
peripheral nerves and a rapidly progressive, ascending
paralysis (ground to brain)
