RN HESI Pharmacology Exam V2 2025
2025/2026 Elite Study Resource | 97 Exam-Style Questions | Accuracy-Verified |
A+ Tier
EXAM OVERVIEW
This 2025/2026 validated resource contains the complete RN HESI Pharmacology
Exam V2 2025 with actual questions and verified answers. The examination measures
analytical reasoning, professional judgment, and practical application through 97
evidence-based scenarios that assess competency in contemporary professional
practice.
EXAM FEATURES
• 97 Evidence-Based Multiple Choice Questions
• Comprehensive Answer Keys with Clinical Rationales
• Critical Analysis and Applied Reasoning Emphasis
• Current 2025 Evidence-Based Practice Standards Integration
• 8 Professional Domains Comprehensively Assessed
• Real-World Application Scenarios with Professional Context
CORE TESTING AREAS
→ Medication Administration & Safety
→ Pharmacokinetics & Pharmacodynamics
→ Autonomic & Cardiovascular Medications
→ Central Nervous System Medications
→ Anti-infective Agents
→ Endocrine Medications
→ Respiratory Medications
→ Gastrointestinal Medications
Page 1
,Question 1
A 45-year-old client with hypertension is prescribed enalapril and tells the nurse that he
has been taking atenolol for 2 years. What instruction should the nurse provide regarding
the new medication?
A. To continue taking atenolol as prescribed and start enalapril at the next scheduled
dose.
B. To stop taking atenolol as soon as enalapril starts and report any side effects.
C. To take enalapril as directed and notify the healthcare provider if they experience any
side effects from stopping atenolol.
D. To report to the healthcare provider that they have been taking atenolol for 2 years and
ask if they should stop taking it.
Correct Answer
C. To take enalapril as directed and notify the healthcare provider if they experience any
side effects from stopping atenolol.
Rationale:
The nurse should instruct the client to take enalapril as directed and report any side effects from stopping
atenolol.
Question 2
A 28-year-old woman with a history of penicillin allergy is prescribed amoxicillin for a 5-
day course of treatment. What should the nurse discuss with the client regarding the new
medication?
A. The potential for cross-reactivity with penicillin and the signs of an allergic reaction.
B. The importance of completing the full course of treatment and not missing any doses.
C. The potential for interactions with other medications she is taking.
D. The need for regular blood checks to monitor the effectiveness of the medication.
Correct Answer
A. The potential for cross-reactivity with penicillin and the signs of an allergic reaction.
Rationale:
The nurse should discuss the potential for cross-reactivity with penicillin and the signs of an allergic reaction.
Page 2
,Question 3
A client prescribed a short-acting Beta-2 receptor agonist for acute asthma exacerbation
exhibits symptoms of anxiety, tremors, and palpitations. What client response should the
nurse expect?
A. Increased heart rate and blood pressure.
B. Decreased respiratory rate and oxygen saturation.
C. Increased salivation and muscle spasms.
D. All of the above.
Correct Answer
D. All of the above.
Rationale:
The nurse should expect the client to exhibit increased heart rate, blood pressure, salivation, and muscle
spasms.
Question 4
A 60-year-old male client with hypertension is prescribed enalapril. What is a potential
side effect of this medication?
A. Increased potassium levels.
B. Decreased potassium levels.
C. Increased sodium levels.
D. Cough and angioedema.
Correct Answer
D. Cough and angioedema.
Rationale:
Enalapril can cause cough and angioedema as a potential side effect.
Page 3
, Question 5
A client prescribed atenolol has a blood pressure of 120/68 mmHg and a heart rate of 58
beats/minute. What should the nurse do?
A. Continue to monitor the client's blood pressure and heart rate.
B. Contact the healthcare provider for further instructions.
C. Administer a medication to increase the client's heart rate.
D. Stop the client's atenolol medication.
Correct Answer
A. Continue to monitor the client's blood pressure and heart rate.
Rationale:
The nurse should continue to monitor the client's blood pressure and heart rate.
Question 6
A 70-year-old male client with a history of hypertension and coronary artery disease is
prescribed metoprolol succinate. He asks the nurse about the difference between
metoprolol succinate and metoprolol tartrate. What does the nurse explain to the client?
A. Metoprolol succinate has a shorter duration of action and is used for hypertension,
whereas metoprolol tartrate is used for angina.
B. Metoprolol succinate has a longer duration of action and is used for hypertension,
whereas metoprolol tartrate is used for heart failure.
C. Metoprolol succinate is a shorter-acting formulation, whereas metoprolol tartrate is a
long-acting formulation.
D. Metoprolol succinate is used for hypertension and has a longer half-life, whereas
metoprolol tartrate is used for angina and has a shorter half-life.
Correct Answer
B. Metoprolol succinate has a longer duration of action and is used for hypertension,
whereas metoprolol tartrate is used for heart failure.
Rationale:
Metoprolol succinate has a longer duration of action and is used for hypertension, whereas metoprolol
tartrate is used for heart failure.
Page 4
2025/2026 Elite Study Resource | 97 Exam-Style Questions | Accuracy-Verified |
A+ Tier
EXAM OVERVIEW
This 2025/2026 validated resource contains the complete RN HESI Pharmacology
Exam V2 2025 with actual questions and verified answers. The examination measures
analytical reasoning, professional judgment, and practical application through 97
evidence-based scenarios that assess competency in contemporary professional
practice.
EXAM FEATURES
• 97 Evidence-Based Multiple Choice Questions
• Comprehensive Answer Keys with Clinical Rationales
• Critical Analysis and Applied Reasoning Emphasis
• Current 2025 Evidence-Based Practice Standards Integration
• 8 Professional Domains Comprehensively Assessed
• Real-World Application Scenarios with Professional Context
CORE TESTING AREAS
→ Medication Administration & Safety
→ Pharmacokinetics & Pharmacodynamics
→ Autonomic & Cardiovascular Medications
→ Central Nervous System Medications
→ Anti-infective Agents
→ Endocrine Medications
→ Respiratory Medications
→ Gastrointestinal Medications
Page 1
,Question 1
A 45-year-old client with hypertension is prescribed enalapril and tells the nurse that he
has been taking atenolol for 2 years. What instruction should the nurse provide regarding
the new medication?
A. To continue taking atenolol as prescribed and start enalapril at the next scheduled
dose.
B. To stop taking atenolol as soon as enalapril starts and report any side effects.
C. To take enalapril as directed and notify the healthcare provider if they experience any
side effects from stopping atenolol.
D. To report to the healthcare provider that they have been taking atenolol for 2 years and
ask if they should stop taking it.
Correct Answer
C. To take enalapril as directed and notify the healthcare provider if they experience any
side effects from stopping atenolol.
Rationale:
The nurse should instruct the client to take enalapril as directed and report any side effects from stopping
atenolol.
Question 2
A 28-year-old woman with a history of penicillin allergy is prescribed amoxicillin for a 5-
day course of treatment. What should the nurse discuss with the client regarding the new
medication?
A. The potential for cross-reactivity with penicillin and the signs of an allergic reaction.
B. The importance of completing the full course of treatment and not missing any doses.
C. The potential for interactions with other medications she is taking.
D. The need for regular blood checks to monitor the effectiveness of the medication.
Correct Answer
A. The potential for cross-reactivity with penicillin and the signs of an allergic reaction.
Rationale:
The nurse should discuss the potential for cross-reactivity with penicillin and the signs of an allergic reaction.
Page 2
,Question 3
A client prescribed a short-acting Beta-2 receptor agonist for acute asthma exacerbation
exhibits symptoms of anxiety, tremors, and palpitations. What client response should the
nurse expect?
A. Increased heart rate and blood pressure.
B. Decreased respiratory rate and oxygen saturation.
C. Increased salivation and muscle spasms.
D. All of the above.
Correct Answer
D. All of the above.
Rationale:
The nurse should expect the client to exhibit increased heart rate, blood pressure, salivation, and muscle
spasms.
Question 4
A 60-year-old male client with hypertension is prescribed enalapril. What is a potential
side effect of this medication?
A. Increased potassium levels.
B. Decreased potassium levels.
C. Increased sodium levels.
D. Cough and angioedema.
Correct Answer
D. Cough and angioedema.
Rationale:
Enalapril can cause cough and angioedema as a potential side effect.
Page 3
, Question 5
A client prescribed atenolol has a blood pressure of 120/68 mmHg and a heart rate of 58
beats/minute. What should the nurse do?
A. Continue to monitor the client's blood pressure and heart rate.
B. Contact the healthcare provider for further instructions.
C. Administer a medication to increase the client's heart rate.
D. Stop the client's atenolol medication.
Correct Answer
A. Continue to monitor the client's blood pressure and heart rate.
Rationale:
The nurse should continue to monitor the client's blood pressure and heart rate.
Question 6
A 70-year-old male client with a history of hypertension and coronary artery disease is
prescribed metoprolol succinate. He asks the nurse about the difference between
metoprolol succinate and metoprolol tartrate. What does the nurse explain to the client?
A. Metoprolol succinate has a shorter duration of action and is used for hypertension,
whereas metoprolol tartrate is used for angina.
B. Metoprolol succinate has a longer duration of action and is used for hypertension,
whereas metoprolol tartrate is used for heart failure.
C. Metoprolol succinate is a shorter-acting formulation, whereas metoprolol tartrate is a
long-acting formulation.
D. Metoprolol succinate is used for hypertension and has a longer half-life, whereas
metoprolol tartrate is used for angina and has a shorter half-life.
Correct Answer
B. Metoprolol succinate has a longer duration of action and is used for hypertension,
whereas metoprolol tartrate is used for heart failure.
Rationale:
Metoprolol succinate has a longer duration of action and is used for hypertension, whereas metoprolol
tartrate is used for heart failure.
Page 4
