NR 565 - advanced pharmacology midterm Questions with Answers (2025 / 2026) (Verified Answers)- Chamberlain.

NR 565 - advanced pharmacology midterm
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8i Questions with Answers () (Verified 8i 8i 8i 8i 8i 8i




8i Answers)- Chamberlain. 8i




1. During what trimester is a pregnant woman most at risk for adverse drug
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reactions with potential long term consequences?
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Answer: 1st trimester (fetus most at risk d/t rapid growth)
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2. What is BEERS criteria?
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Answer: Recommendations of medications inappropriate for elderly (65 and older), prescriber ultimately decides
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3. What is the CYP450 (cytochrome P450)
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Answer: liver enzyme system where medications are metabolized, can either be inducers or inhibitors and create drug-
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drug interactions
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4. CYP450 inducers 8 i




Answer: Speed up metabolism of drugs (drug is cleared faster), drug has lesser ettect (decrease blood levels of drug),
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elevate CYP450 enzymes
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5. CYP450 inducers pneumonic Answer: "Bullshit Crap GPS INDUCES rage"
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, 6. CYP450 inducer drug names 8i 8i 8i




Answer: Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital,
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sulfonylureas
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7. CYP450 inhibitors Answer: inhibit metabolism, increase blood levels of medications
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8. CYP450 pneumonic Answer: "VISA credit card debt INHIBITS spending on designers like CK to look GQ"
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9. CYP450 inhibitors drug name Answer s: Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol,
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ketoconazole, grapefruit juice, quinidine
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10. Physiological changes during pregnancy that impact pharmacodynamics 8 i 8 i 8 i 8 i 8 i 8 i




8 and pharmacokinetic properties of drugs?
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Answer: increase glomerular filtration rate leads to increase durg excretion
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increase hepatic metabolism decrease
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tone and motility of bowel increase drug
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absorption
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11. Examples of medications that can be teratogenic 8i 8i 8i 8i 8i 8i




Answer: Antiepileptic drugs, antimicrobials such 8 i 8i 8i 8i




as tetracyclines and fluoroquinolones, vitamin A in large doses, some anticoagulants, and hormonal medications suchas diethylstilbestrol
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(DES).
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12. How is absorption of intramuscular medications different in neonates?
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Answer: slow 8 i




and erratic due to low blood flow in muscles first few days of life
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13. Whyis absorption of medication in thestomach increased in infancy?
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, Answer: delayed gastric emptying
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14. Some medications that shouldbe avoided in the pediatricpatient?
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Answer: glucocorti- coids, discoloration of developing teeth with tetracyclines, and kernicterus with sulfonamides,
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levofloxacin (antibiotics) aspirin (Severe intoxication from acute overdose)
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, 15. what should be included in medication administration patient education?: 8 i 8 i 8 i 8 i 8 i 8 i 8 i 8 i




8 i - dosage size and timing
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route and technique of administration duration of
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treatment
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drug storage 8i




nature and time course of desired responses 8i 8i 8i 8i 8i 8i




nature and time course of adverse responses
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finish taking antibiotic
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16. What are some things that put the elderly patient at higher risk for 8 i 8 i 8 i 8 i 8 i 8 i 8 i 8 i 8 i 8 i 8 i 8 i




adverse drug reactions?: reduced renal function polypharmacy
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(theuseoffive ormoremedicationsdaily) greaterseverityof illness
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presence ofcomorbidities 8i 8i




use of drugs that have a low therapeutic index (e.g., digoxin) increased individual
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variation secondary to altered pharmacokinetics inadequate supervision of
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long-term therapy
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poor patient adherence 8 i 8 i




17. How can healthcare providers decrease likelihood of an elderly patient expe- riencing an
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8 adverse drug reaction?: obtaining a thorough drug history that includes over-the-counter medications
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considering pharmacokinetic and pharmacodynamics changes due to age monitoring
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8 the patient's clinical response and plasma drug levels
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