Nightingale College | Real Exam 100 Q&A
This updated 2025/2026 resource includes fully verified questions and correct answers
from the BSN 266 Medical-Surgical HESI Exam used at Nightingale College. Aligned with
the latest HESI blueprint, it covers essential Med Surg topics such as respiratory and
cardiovascular disorders, perioperative care, pharmacology, fluid and electrolyte
balance, and patient safety. Designed to mirror the actual exam, this guide provides
reliable preparation for nursing students aiming to excel in their HESI assessments.
The nurse is completing a health assessment of a 42-year-old female with suspected Graves' disease.
The nurse should assess this client for:
A. Anorexia
B. Tachycardia
C. Weight Gain
D. Cold Skin - correct answer -B. Tachycardia
A client's bone marrow report reveals normal stem cells and precursors of platelets (megakaryocytes)
in the presence of decreased circulating platelets. The nurse recognizes a knowledge deficit when the
client makes which of the following statements?
A. "I need to stop flossing and throw away my hard toothbrush."
B. "I am glad that my report turned out normal."
C. "Now I know why I have all these bruises."
D. "I shouldn't jump off that last step anymore." - correct answer -B. "I am glad that my report turned
out normal."
The nurse should assess a client with thrombocytopenia who has developed a hemorrhage for which
of the following?
A. Tachycardia.
B. Bradycardia.
C. Decreased PaCO2.
D. Narrowed pulse pressure. - correct answer -A. Tachycardia
,The client with idiopathic thrombocytopenic purpura (ITP) asks the nurse why it is necessary to take
steroids. Which is the nurse's best response?
A. Steroids destroy the antibodies and prolong the life of platelets.
B. Steroids neutralize the antigens and prolong the life of platelets.
C. Steroids increase phagocytosis and increase the life of platelets.
D. Steroids alter the spleen's recognition of platelets and increase the life of platelets. - correct answer
-D. Steroids alter the spleen's recognition of platelets and increase the life of platelets.
A client is to be discharged on prednisone. Which of the following statements indicates that the client
understands important concepts about the medication therapy?
A. "I need to take the medicine in divided doses at morning and bedtime."
B. "I am to take 40 mg of prednisone for 2 months and then stop."
C. "I need to wear or carry identification that I am taking prednisone."
D. "Prednisone will give me extra protection from colds and flu." - correct answer -C. "I need to wear
or carry identification that I am taking prednisone."
When teaching the client older than age 50 who is receiving long-term prednisone therapy, the nurse
should recommend which of the following?
A. Take the prednisone with food.
B. Take over-the-counter drugs as needed.
C. Exercise three to four times a week.
D. Eat foods that are low in potassium. - correct answer -A. Take the prednisone with food.
The nurse is preparing a teaching plan about increased exercise for a female client who is receiving
long-term corticosteroid therapy. What type of exercise is most appropriate for this client?
A. Floor exercises.
B. Stretching.
C. Running.
D. Walking. - correct answer -D. Walking
, The nurse is teaching a female client with a history of acquired thrombocytopenia about how to
prevent and control hemorrhage. Which statement indicates that the client needs further instruction?
A. "I can apply direct pressure over small cuts for at least 5 to 10 minutes to stop a venous bleed."
B. "I can count the number of tissues saturated to detect blood loss during a nosebleed."
C. "I can take hormones to decrease blood loss during menses."
D. "I can count the number of sanitary napkins to detect excess blood loss during menses." - correct
answer -B. "I can count the number of tissues saturated to detect blood loss during a nosebleed."
A client has been on long-term prednisone therapy. The nurse should instruct the client to consume a
diet high in which of the following? Select all that apply.
A. Carbohydrate.
B. Protein.
C. Trans fat.
D. Potassium.
E. Calcium.
F. Vitamin D. - correct answer -B. Protein
D. Potassium
E. Calcium
F. Vitamin D
Platelets should not be administered under which of the following conditions?
A. The platelet bag is cold.
B. The platelets are 2 days old.
C. The platelet bag is at room temperature.
D. The platelets are 12 hours old. - correct answer -A. The platelet bag is cold.
The nurse is preparing to administer platelets. The nurse should:
A. Check the ABO compatibility.
B. Administer the platelets slowly.
C. Gently rotate the bag.