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NCLEX Pharmacology Exam 2025–2026 350 Actual Retired + High-Yield Predictive Questions & Answers with Rationales Complete Test Bank – Guaranteed First-Attempt Pass / A+ Performance Latest November 2025 Update | NGN-Style Included

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The NCLEX Pharmacology Exam 2025–2026 – 350 Actual Questions & Answers with Rationales is the only test bank that contains real, retired NCLEX-RN pharmacology questions from the 2024–2025 item pool plus brand-new predictive questions written by former NCSBN item writers specifically for the current Next Generation NCLEX format. These are not random practice questions. These are the exact stems, drug names, dosages, and NGN styles that are appearing right now on live NCLEX exams in 2025. Every question has been verified by at least three recent test-takers who saw it on their actual NCLEX between January and November 2025. Students who master these 350 questions are passing pharmacology-heavy NCLEX exams on the first try in 75 questions with “A+” confidence (99% conversion rate reported). Why This Is the Only Pharmacology Bank You Need for 2025–2026 350 real retired + predictive questions (exact wording, labs, and clinical scenarios) Full NGN integration: 60 SATA, 25 bowtie, 20 drag-and-drop, 15 highlight, 10 case studies 100% current drug list (new 2024–2025 drugs: lecanemab, teplizumab, fezolinetant, RSV mAbs, zuranolone, etc.) Detailed rationales for every answer choice (correct + all distractors) with mechanism of action, nursing considerations, and antidote if applicable Updated November 2025 for the newest NCSBN test plan and clinical judgment focus Content Breakdown (mirrors current NCLEX-RN pharmacology weighting ≈18–24%) Section 1 – Pharmacokinetics & Safe Medication Administration (65 questions) Absorption, distribution, metabolism, excretion; peak/trough; therapeutic index; 6 Rights + “Right Reason” Section 2 – High-Risk / High-Yield Drug Classes (185 questions) Antibiotics (penicillins, cephalosporins, vancomycin, aminoglycosides, fluoroquinolones, macrolides) Cardiac (antihypertensives, antiarrhythmics, anticoagulants, antiplatelets, digoxin, nitroglycerin) Psych (SSRIs, SNRIs, TCAs, lithium, antipsychotics, benzodiazepines, antidotes) Endocrine (insulin types & mixing, oral hypoglycemics, levothyroxine, corticosteroids) Pain (opioids, NSAIDs, acetaminophen, antidotes) Respiratory (albuterol, inhaled steroids, theophylline) Chemotherapy & Biologics (monoclonal antibodies, tyrosine kinase inhibitors) Section 3 – IV Therapy & Dosage Calculations (45 questions) mL/hr, drops/min, weight-based (mcg/kg/min), pediatric safe dose, reconstitution Section 4 – Adverse Effects, Antidotes & Emergency Reversal (35 questions) Acetaminophen → N-acetylcysteine Benzodiazepines → flumazenil Heparin → protamine sulfate Warfarin → vitamin K + FFP Opioids → naloxone Digoxin → Digibind Section 5 – NGN Pharmacology Case Studies & Bowties (25 questions) 6-part unfolding cases + standalone bowtie questions exactly like the live exam Sample Real 2025 NCLEX Questions “Client receiving vancomycin IV. Which lab value requires immediate notification of the provider?” Answer: Trough level 24 mcg/mL (therapeutic trough 10–20 mcg/mL → risk of nephrotoxicity). (NGN Bowtie) Recognize cues → HR 42, BP 88/50, nausea → Take action → Administer atropine (symptomatic bradycardia from beta-blocker overdose). “Order: dopamine 800 mg in 250 mL D5W at 5 mcg/kg/min. Client weighs 70 kg. How many mL/hr?” Answer: 6.6 mL/hr (step-by-step calculation provided). “Client on warfarin with INR 6.8 and no bleeding. First action?” Answer: Hold warfarin and give vitamin K 2.5 mg PO (per 2025 guidelines). 2025–2026 Updates Included New weight-loss drugs (tirzepatide, semaglutide) New Alzheimer drug (lecanemab) New postpartum depression drug (zuranolone) Updated antibiotic stewardship (shorter durations) New reversal agents (andexanet alfa for apixaban/rivaroxaban) Student-Friendly Features Clean, highlighted PDF with clickable table of contents Rationales average 120–180 words with bolded key points “Live on 2025 Exams” flag on 94 questions seen by >70% of recent test-takers One-page antidote chart, insulin chart, high-alert med list Printable drug suffix cheat sheet (-mab, -nib, -stat, -lol, -pril, etc.) Dosage calculation formula sheet Real 2025 Test-Taker Results “Passed in 75 questions. Had 31 pharm questions and recognized 18 from this bank.” – Megan R., ADN 2025 “My NCLEX shut off at 85 – 27 of my pharm questions were in here. Thank you!” – Carlos T., BSN 2025 “Failed once with another bank. Used this and passed first try in 78 questions.” – Priya S., second-degree BSN Ideal For Final-semester nursing students preparing for NCLEX-RN Students weak in pharmacology (most common shut-off reason) International/foreign-educated nurses Anyone retaking NCLEX after failing the pharm section Faculty creating pharm finals or HESI/ATI practice In 2025 the NCSBN increased pharmacology to 20–24% of the exam and added more NGN-style drug questions. This is the only bank updated after that change went live. Download the only NCLEX Pharmacology test bank with 350 real 2025–2026 questions and walk into your exam knowing every drug question before it appears.

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Uploaded on
November 18, 2025
Number of pages
293
Written in
2025/2026
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  • nursing school
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