NAPLEX EXAM QUESTIONS &
ANSWERS, WELL ELABORATED |
ALREADY VERIFIED TEST |100%
VERIFIED SOLUTIONS | 2025\2026
LATEST!!
1. Beyond use date must be applied to each compounded product using USP 795 guidelines
for Nonaqueous Liquids, Solid formulations, and Water-containing Formulations.
A. True
B. False
✅ Answer: A
Rationale: USP 795 requires beyond use dates (BUDs) for all compounded non-sterile
preparations to ensure safety and stability.
2. Which USP guideline is considered for Non-Sterile Preparations?
A. USP 795
B. USP 797
C. Both
D. None
✅ Answer: A
Rationale: USP 795 specifically addresses non-sterile compounding, while USP 797 applies to
sterile compounding.
3. What is the beyond use date for water-containing oral formulations?
A. 7 days at room temperature
B. 14 days at controlled cold temperature
C. 30 days at room temperature
D. 6 months
✅ Answer: B
Rationale: Water-containing oral formulations have a limited shelf-life to reduce microbial
growth; hence, the BUD is 14 days under cold storage.
4. For capsules, the label must include mcg or mg/capsule.
A. True
B. False
✅ Answer: A
1
,Rationale: Dosage per capsule must be stated for accuracy and patient safety, unlike tablets
where it is optional.
5. Can compounding equipment be rinsed with tap water?
A. Yes
B. No
✅ Answer: B
Rationale: Only purified water should be used to avoid contamination in compounded
preparations.
6. What is the best certified sterile compounding environment for injectable products?
A. ISO class 7 laminar flow hood in class 10 room
B. ISO class 5 laminar air flow hood within ISO class 7 clean room with positive air pressure
C. Class 1000 hood only
D. Class 10 hood only
✅ Answer: B
Rationale: Sterile compounding requires ISO class 5 environment within a controlled ISO class
7 clean room to minimize contamination risk.
7. When measuring liquids in a container, where should you measure?
A. Top of meniscus
B. Bottom of meniscus
✅ Answer: B
Rationale: Accurate liquid measurement is done at the bottom of the meniscus to prevent dosing
errors.
8. Difference between glass and wedge-wood/porcelain mortar and pestle:
A. Glass for dry powders, porcelain for liquids
B. Porcelain for dry powders, glass for liquids or oily/staining chemicals
C. Both are interchangeable
D. Glass for ointments only
✅ Answer: B
Rationale: Porcelain reduces particle size for powders; glass is chemically resistant and ideal for
liquids.
9. Is it safe not to use ointment paper when preparing creams and lotions?
A. True
B. False
✅ Answer: A
Rationale: Creams and lotions have high water content that may moisten and tear paper;
glassine weighing paper is preferred.
10. Which levigating agent is best for aqueous systems (O/W dispersions)?
A. Glycerin
B. Mineral oil
C. Castor oil
2
,D. Tween 80
✅ Answer: A
Rationale: Glycerin, propylene glycol, and PEG 80 are hydrophilic and suitable for water-based
systems; oils are for oleaginous systems.
11. Best way to prevent overheating during compounding?
A. Use a water bath
B. Heat directly on flame
C. Use microwave
D. Mix without temperature control
✅ Answer: A
Rationale: A water bath ensures controlled, uniform heating and prevents unwanted chemical
reactions.
12. Compounds prepared without a specific formula to meet individual patient needs are
called:
A. Extemporaneous
B. Emulsions
C. Ointments
D. Suspensions
✅ Answer: A
Rationale: Extemporaneous preparations are customized formulations made to meet patient-
specific requirements.
13. A single agent used to soften and smooth the skin is called:
A. Emollients
B. Moisturizers
C. Occlusive agents
D. Humectants
✅ Answer: A
Rationale: Emollients refer to single-agent skin softeners; moisturizers often contain additional
ingredients.
14. Oil-in-water or water-in-oil is an example of:
A. Suspension
B. Emulsion
C. Gel
D. Solution
✅ Answer: B
Rationale: Emulsions are mixtures of two immiscible liquids stabilized by emulsifiers.
15. What stabilizes an emulsion?
A. Emulsifiers
B. Emollients
C. Solvents
D. Gelling agents
3
, ✅ Answer: A
Rationale: Emulsifiers reduce surface tension, allowing oil and water to mix without separating.
16. What is the difference between Continental (dry gum) and English (wet gum) methods
for emulsions?
A. Both have same ingredients, but dry gum mixes gum with water first
B. Both have same ingredients, dry gum mixes gum with oil first; wet gum dissolves gum in
water first
C. Dry gum uses water only, wet gum uses oil only
D. They are identical in procedure
✅ Answer: B
Rationale: Both use oil, water, and gum in 4:2:1 ratio; the order differs to control emulsion
formation and stability.
17. HLB (Hydrophilic-Lipophilic Balance) number indicates:
A. Solubility in alcohol only
B. 0–20 scale; #>10 hydrophilic, #<10 lipophilic
C. pH of emulsions
D. Viscosity of ointments
✅ Answer: B
Rationale: HLB determines solubility preference of emulsifiers; crucial for stabilizing
emulsions.
18. A eutectic mixture:
A. Melts at a higher temperature than individual components
B. Melts at a lower temperature than individual components
C. Does not melt
D. Is always a liquid
✅ Answer: B
Rationale: Eutectic mixtures liquefy at a temperature below their individual components’
melting points, which can affect compounding.
19. Common preservatives in compounded preparations include:
A. Benzalkonium chloride (BAK)
B. Benzyl alcohol
C. Chlorhexidine
D. Thimerosal
E. Sodium benzoate
F. Benzethonium chloride
G. Propylparaben
✅ Answer: All of the above
Rationale: Preservatives prevent microbial growth in formulations; choice depends on
preparation type and compatibility.
20. Why are preservative-free formulations encouraged even if multi-dose vials contain
preservatives?
4
ANSWERS, WELL ELABORATED |
ALREADY VERIFIED TEST |100%
VERIFIED SOLUTIONS | 2025\2026
LATEST!!
1. Beyond use date must be applied to each compounded product using USP 795 guidelines
for Nonaqueous Liquids, Solid formulations, and Water-containing Formulations.
A. True
B. False
✅ Answer: A
Rationale: USP 795 requires beyond use dates (BUDs) for all compounded non-sterile
preparations to ensure safety and stability.
2. Which USP guideline is considered for Non-Sterile Preparations?
A. USP 795
B. USP 797
C. Both
D. None
✅ Answer: A
Rationale: USP 795 specifically addresses non-sterile compounding, while USP 797 applies to
sterile compounding.
3. What is the beyond use date for water-containing oral formulations?
A. 7 days at room temperature
B. 14 days at controlled cold temperature
C. 30 days at room temperature
D. 6 months
✅ Answer: B
Rationale: Water-containing oral formulations have a limited shelf-life to reduce microbial
growth; hence, the BUD is 14 days under cold storage.
4. For capsules, the label must include mcg or mg/capsule.
A. True
B. False
✅ Answer: A
1
,Rationale: Dosage per capsule must be stated for accuracy and patient safety, unlike tablets
where it is optional.
5. Can compounding equipment be rinsed with tap water?
A. Yes
B. No
✅ Answer: B
Rationale: Only purified water should be used to avoid contamination in compounded
preparations.
6. What is the best certified sterile compounding environment for injectable products?
A. ISO class 7 laminar flow hood in class 10 room
B. ISO class 5 laminar air flow hood within ISO class 7 clean room with positive air pressure
C. Class 1000 hood only
D. Class 10 hood only
✅ Answer: B
Rationale: Sterile compounding requires ISO class 5 environment within a controlled ISO class
7 clean room to minimize contamination risk.
7. When measuring liquids in a container, where should you measure?
A. Top of meniscus
B. Bottom of meniscus
✅ Answer: B
Rationale: Accurate liquid measurement is done at the bottom of the meniscus to prevent dosing
errors.
8. Difference between glass and wedge-wood/porcelain mortar and pestle:
A. Glass for dry powders, porcelain for liquids
B. Porcelain for dry powders, glass for liquids or oily/staining chemicals
C. Both are interchangeable
D. Glass for ointments only
✅ Answer: B
Rationale: Porcelain reduces particle size for powders; glass is chemically resistant and ideal for
liquids.
9. Is it safe not to use ointment paper when preparing creams and lotions?
A. True
B. False
✅ Answer: A
Rationale: Creams and lotions have high water content that may moisten and tear paper;
glassine weighing paper is preferred.
10. Which levigating agent is best for aqueous systems (O/W dispersions)?
A. Glycerin
B. Mineral oil
C. Castor oil
2
,D. Tween 80
✅ Answer: A
Rationale: Glycerin, propylene glycol, and PEG 80 are hydrophilic and suitable for water-based
systems; oils are for oleaginous systems.
11. Best way to prevent overheating during compounding?
A. Use a water bath
B. Heat directly on flame
C. Use microwave
D. Mix without temperature control
✅ Answer: A
Rationale: A water bath ensures controlled, uniform heating and prevents unwanted chemical
reactions.
12. Compounds prepared without a specific formula to meet individual patient needs are
called:
A. Extemporaneous
B. Emulsions
C. Ointments
D. Suspensions
✅ Answer: A
Rationale: Extemporaneous preparations are customized formulations made to meet patient-
specific requirements.
13. A single agent used to soften and smooth the skin is called:
A. Emollients
B. Moisturizers
C. Occlusive agents
D. Humectants
✅ Answer: A
Rationale: Emollients refer to single-agent skin softeners; moisturizers often contain additional
ingredients.
14. Oil-in-water or water-in-oil is an example of:
A. Suspension
B. Emulsion
C. Gel
D. Solution
✅ Answer: B
Rationale: Emulsions are mixtures of two immiscible liquids stabilized by emulsifiers.
15. What stabilizes an emulsion?
A. Emulsifiers
B. Emollients
C. Solvents
D. Gelling agents
3
, ✅ Answer: A
Rationale: Emulsifiers reduce surface tension, allowing oil and water to mix without separating.
16. What is the difference between Continental (dry gum) and English (wet gum) methods
for emulsions?
A. Both have same ingredients, but dry gum mixes gum with water first
B. Both have same ingredients, dry gum mixes gum with oil first; wet gum dissolves gum in
water first
C. Dry gum uses water only, wet gum uses oil only
D. They are identical in procedure
✅ Answer: B
Rationale: Both use oil, water, and gum in 4:2:1 ratio; the order differs to control emulsion
formation and stability.
17. HLB (Hydrophilic-Lipophilic Balance) number indicates:
A. Solubility in alcohol only
B. 0–20 scale; #>10 hydrophilic, #<10 lipophilic
C. pH of emulsions
D. Viscosity of ointments
✅ Answer: B
Rationale: HLB determines solubility preference of emulsifiers; crucial for stabilizing
emulsions.
18. A eutectic mixture:
A. Melts at a higher temperature than individual components
B. Melts at a lower temperature than individual components
C. Does not melt
D. Is always a liquid
✅ Answer: B
Rationale: Eutectic mixtures liquefy at a temperature below their individual components’
melting points, which can affect compounding.
19. Common preservatives in compounded preparations include:
A. Benzalkonium chloride (BAK)
B. Benzyl alcohol
C. Chlorhexidine
D. Thimerosal
E. Sodium benzoate
F. Benzethonium chloride
G. Propylparaben
✅ Answer: All of the above
Rationale: Preservatives prevent microbial growth in formulations; choice depends on
preparation type and compatibility.
20. Why are preservative-free formulations encouraged even if multi-dose vials contain
preservatives?
4
