,Table of Contents
GB GB
Chapter 01 Properties and Overview of Immune Responses
GB GB GB GB GB GB GB 1
Chapter 02 Cells and Tissues of the Immune System
GB GB GB GB GB GB GB GB 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
GB GB GB GB GB GB GB 6
Chapter 04 Innate Immunity
GB GB GB 10
Chapter 05 Antibodies and Antigens
GB GB GB GB 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
GB GB GB GB GB GB GB GB GB GB GB
Histocompatibility Complex Molecules
GB GB 20
Chapter 07 Immune Receptors and Signal Transduction
GB GB GB GB GB GB 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
GB GB GB GB GB GB GB GB 30
Chapter 09 Activation of T Lymphocytes
GB GB GB GB GB 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
GB GB GB GB GB GB GB GB GB 38
ChapterGB 11 Differentiation and Functions of CD8+ Effector T Cells
GB GB GB GB GB GB GB GB 42
ChapterGB 12 B Cell Activation and Antibody Production
GB GB GB GB GB GB 46
ChapterGB 13 Effector Mechanisms of Humoral Immunity
GB GB GB GB GB 52
ChapterGB 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
GB GB GB GB GB GB GB GB GB GB 56
ChapterGB 15 Immunologic Tolerance and Autoimmunity
GB GB GB GB 62
ChapterGB 16 Immunity to Microbes
GB GB GB 67
ChapterGB 17 Transplantation Immunology
GB GB 72
ChapterGB 18 Tumor Immunology
GB GB 77
Chapter 19 Hypersensitivity Disorders
GB GB GB 81
Chapter 20 Allergy
GB GB 86
Chapter 21 Primary and Acquired Immunodeficiencies
GB GB GB GB GB 89
,Chapter 01: Properties and Overview of Immune Responses
GB GB GB GB GB GB GB
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
GB GB GB GB GB GB GB GB GB
MULTIPLE CHOICE GB
1. The principal function of the immune system is:
GB GB GB GB GB GB GB
a. Defense against cancer GB GB
b. Repair of injured tissues GB GB GB
c. Defense against microbial infections GB GB GB
d. Prevention of inflammatory diseases GB GB GB
e. Protection against environmental toxins GB GB GB
ANS: C G B
The immune system has evolved in the setting of selective pressures imposed by mic
GB GB GB GB GB GB GB GB GB GB GB GB GB
robial infections. Although immune responses to cancer may occur, the concept that
GB GB GB GB GB GB GB GB GB GB GB GB
“immunosurveillance” against cancer is a principal function of the immune system isGB GB GB GB GB GB GB GB GB GB GB G
Bcontroversial. Repair of injured tissues may be a secondary consequence of the imm
GB GB GB GB GB GB GB GB GB GB GB GB
une responses and inflammation. Although the immune system has regulatory feature
GB GB GB GB GB GB GB GB GB GB
s that are needed to prevent excessive inflammation, prevention of inflammatory dise
GB GB GB GB GB GB GB GB GB GB GB
ases is not a primary function. The immune system can protect against microbial toxi
GB GB GB GB GB GB GB GB GB GB GB GB GB
ns, but it generally does not offer protection against toxins of nonbiologic origin.
GB GB GB GB GB GB GB GB GB GB GB GB
2. Which of the following infectious diseases was prevented by the first succe
GB GB GB GB GB GB GB GB GB GB GB
ssful vaccination?
GB
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C G B
In 1798, Edward Jenner reported the first intentional successful vaccination, which w
GB GB GB GB GB GB GB GB GB GB GB
as against smallpox in a boy, using material from the cowpox pustules of a milkmaid.
GB GB GB GB GB GB GB GB GB GB GB GB GB GB
In 1980, smallpox was reported to be eradicated worldwide by a vaccination progra
GB GB GB GB GB GB GB GB GB GB GB GB GB
m. Effective vaccines against tetanus toxin, rubella virus, and poliovirus were develo
GB GB GB GB GB GB GB GB GB GB GB
ped in the 20th century and are widely used. There is no effective vaccine against
GB GB GB GB GB GB GB GB GB GB GB GB GB GB GB
Mycobacterium tuberculosis. GB
3. Which of the following is a unique property of the adaptive immune system?
GB GB GB GB GB GB GB GB GB GB GB GB
a. Highly diverse repertoire of specificities for antigens
GB GB GB GB GB GB
b. Self-nonself discrimination GB
c. Recognition of microbial structures by both cell-associated and soluble receptors
GB GB GB GB GB GB GB GB GB
d. Protection against viral infections GB GB GB
e. Responses that have the same kinetics and magnitude on repeated exposure t
GB GB GB GB GB GB GB GB GB GB GB
o the same microbe
GB GB GB
ANS: G B A
, Highly diverse repertoires of specificities for antigens are found only in T and B ly
GB GB GB GB GB GB GB GB GB GB GB GB GB GB
mphocytes, which are the central cellular components of the adaptive immune system
GB GB GB GB GB GB GB GB GB GB GB
. Both the innate and the adaptive immune systems use cell-
GB GB GB GB GB GB GB GB GB GB
associated and soluble receptors to recognize microbes, display some degree of self-
GB GB GB GB GB GB GB GB GB GB GB
nonself discrimination, and protect against viruses. On repeated exposure to the same
GB GB GB GB GB GB GB GB GB GB GB G
Bmicrobe, the adaptive immune response becomes more rapid and of greater magnitud
GB GB GB GB GB GB GB GB GB GB GB
e; this is the manifestation of memory.
GB GB GB GB GB GB
4. Antibodies and T lymphocytes are the respective mediators of which two typ
GB GB GB GB GB GB GB GB GB GB GB
es of immunity?
GB GB
a. Innate and adaptive GB GB
b. Passive and active GB GB
c. Specific and nonspecific GB GB
d. Humoral and cell-mediated GB GB
e. Adult and neonatal GB GB
ANS: D G B
Both B and T lymphocytes are principal components of adaptive immunity. B lympho
GB GB GB GB GB GB GB GB GB GB GB GB
cytes produce antibodies, which are the recognition and effector molecules of humoral
GB GB GB GB GB GB GB GB GB GB GB
immune responses to extracellular pathogens. T cells recognize and promote eradicati
GB GB GB GB GB GB GB GB GB GB GB
on of intracellular pathogens in cell-
GB GB GB GB GB
mediated immunity. Passive and active immunity both can be mediated by either B or
GB GB GB GB GB GB GB GB GB GB GB GB GB G
BT lymphocytes. Specific immunity is another term for adaptive immunity. Both B and
GB GB GB GB GB GB GB GB GB GB GB GB G
BT lymphocytes participate in adult adaptive immunity but are still developing in the
GB GB GB GB GB GB GB GB GB GB GB GB GB
neonatal period. GB
5. The two major functional classes of effector T lymphocytes are:
GB GB GB GB GB GB GB GB GB
a. Helper T lymphocytes and cytotoxic T lymphocytes
GB GB GB GB GB GB
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
GB cyStes GB GB GB
c. Memory T cells and effector T cells GB GB GB GB GB GB
d. Helper cells and antigen-presenting cells
GB GB GB GB
e. Cytotoxic T lymphocytes and target cells GB GB GB GB GB
ANS: A G B
T cells can be classified into effector subsets that perform different effector functions.
GB GB GB GB GB GB GB GB GB GB GB GB G
Most effector T cells are either helper T lymphocytes, which enhance the responses
B GB GB GB GB GB GB GB GB GB GB GB GB GB
of other immune cells, including phagocytes and B cells, to infections, or cytotoxic
GB GB GB GB GB GB GB GB GB GB GB GB GB
T lymphocytes, which directly kill infected cells. Natural killer cells are not T lymp
GB GB GB GB GB GB GB GB GB GB GB GB GB
hocytes.
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells.
GB GB GB GB GB GB GB GB GB GB GB GB GB GB
6. Which of the following cell types is required for all adaptive humoral immune responses?
GB GB GB GB GB GB GB GB GB GB GB GB GB
a. Natural killer cells GB GB
b. Dendritic cells GB
c. Cytolytic T lymphocytes GB GB
d. B lymphocytes GB
e. Helper T lymphocytes GB GB
ANS: D G B
Humoral immune responses are antibody-
GB GB GB GB
mediated immune responses, and all antibodies are made by B lymphocytes and no
GB GB GB GB GB GB GB GB GB GB GB GB
other cell type.
GB GB GB
GB GB
Chapter 01 Properties and Overview of Immune Responses
GB GB GB GB GB GB GB 1
Chapter 02 Cells and Tissues of the Immune System
GB GB GB GB GB GB GB GB 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
GB GB GB GB GB GB GB 6
Chapter 04 Innate Immunity
GB GB GB 10
Chapter 05 Antibodies and Antigens
GB GB GB GB 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
GB GB GB GB GB GB GB GB GB GB GB
Histocompatibility Complex Molecules
GB GB 20
Chapter 07 Immune Receptors and Signal Transduction
GB GB GB GB GB GB 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
GB GB GB GB GB GB GB GB 30
Chapter 09 Activation of T Lymphocytes
GB GB GB GB GB 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
GB GB GB GB GB GB GB GB GB 38
ChapterGB 11 Differentiation and Functions of CD8+ Effector T Cells
GB GB GB GB GB GB GB GB 42
ChapterGB 12 B Cell Activation and Antibody Production
GB GB GB GB GB GB 46
ChapterGB 13 Effector Mechanisms of Humoral Immunity
GB GB GB GB GB 52
ChapterGB 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
GB GB GB GB GB GB GB GB GB GB 56
ChapterGB 15 Immunologic Tolerance and Autoimmunity
GB GB GB GB 62
ChapterGB 16 Immunity to Microbes
GB GB GB 67
ChapterGB 17 Transplantation Immunology
GB GB 72
ChapterGB 18 Tumor Immunology
GB GB 77
Chapter 19 Hypersensitivity Disorders
GB GB GB 81
Chapter 20 Allergy
GB GB 86
Chapter 21 Primary and Acquired Immunodeficiencies
GB GB GB GB GB 89
,Chapter 01: Properties and Overview of Immune Responses
GB GB GB GB GB GB GB
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
GB GB GB GB GB GB GB GB GB
MULTIPLE CHOICE GB
1. The principal function of the immune system is:
GB GB GB GB GB GB GB
a. Defense against cancer GB GB
b. Repair of injured tissues GB GB GB
c. Defense against microbial infections GB GB GB
d. Prevention of inflammatory diseases GB GB GB
e. Protection against environmental toxins GB GB GB
ANS: C G B
The immune system has evolved in the setting of selective pressures imposed by mic
GB GB GB GB GB GB GB GB GB GB GB GB GB
robial infections. Although immune responses to cancer may occur, the concept that
GB GB GB GB GB GB GB GB GB GB GB GB
“immunosurveillance” against cancer is a principal function of the immune system isGB GB GB GB GB GB GB GB GB GB GB G
Bcontroversial. Repair of injured tissues may be a secondary consequence of the imm
GB GB GB GB GB GB GB GB GB GB GB GB
une responses and inflammation. Although the immune system has regulatory feature
GB GB GB GB GB GB GB GB GB GB
s that are needed to prevent excessive inflammation, prevention of inflammatory dise
GB GB GB GB GB GB GB GB GB GB GB
ases is not a primary function. The immune system can protect against microbial toxi
GB GB GB GB GB GB GB GB GB GB GB GB GB
ns, but it generally does not offer protection against toxins of nonbiologic origin.
GB GB GB GB GB GB GB GB GB GB GB GB
2. Which of the following infectious diseases was prevented by the first succe
GB GB GB GB GB GB GB GB GB GB GB
ssful vaccination?
GB
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C G B
In 1798, Edward Jenner reported the first intentional successful vaccination, which w
GB GB GB GB GB GB GB GB GB GB GB
as against smallpox in a boy, using material from the cowpox pustules of a milkmaid.
GB GB GB GB GB GB GB GB GB GB GB GB GB GB
In 1980, smallpox was reported to be eradicated worldwide by a vaccination progra
GB GB GB GB GB GB GB GB GB GB GB GB GB
m. Effective vaccines against tetanus toxin, rubella virus, and poliovirus were develo
GB GB GB GB GB GB GB GB GB GB GB
ped in the 20th century and are widely used. There is no effective vaccine against
GB GB GB GB GB GB GB GB GB GB GB GB GB GB GB
Mycobacterium tuberculosis. GB
3. Which of the following is a unique property of the adaptive immune system?
GB GB GB GB GB GB GB GB GB GB GB GB
a. Highly diverse repertoire of specificities for antigens
GB GB GB GB GB GB
b. Self-nonself discrimination GB
c. Recognition of microbial structures by both cell-associated and soluble receptors
GB GB GB GB GB GB GB GB GB
d. Protection against viral infections GB GB GB
e. Responses that have the same kinetics and magnitude on repeated exposure t
GB GB GB GB GB GB GB GB GB GB GB
o the same microbe
GB GB GB
ANS: G B A
, Highly diverse repertoires of specificities for antigens are found only in T and B ly
GB GB GB GB GB GB GB GB GB GB GB GB GB GB
mphocytes, which are the central cellular components of the adaptive immune system
GB GB GB GB GB GB GB GB GB GB GB
. Both the innate and the adaptive immune systems use cell-
GB GB GB GB GB GB GB GB GB GB
associated and soluble receptors to recognize microbes, display some degree of self-
GB GB GB GB GB GB GB GB GB GB GB
nonself discrimination, and protect against viruses. On repeated exposure to the same
GB GB GB GB GB GB GB GB GB GB GB G
Bmicrobe, the adaptive immune response becomes more rapid and of greater magnitud
GB GB GB GB GB GB GB GB GB GB GB
e; this is the manifestation of memory.
GB GB GB GB GB GB
4. Antibodies and T lymphocytes are the respective mediators of which two typ
GB GB GB GB GB GB GB GB GB GB GB
es of immunity?
GB GB
a. Innate and adaptive GB GB
b. Passive and active GB GB
c. Specific and nonspecific GB GB
d. Humoral and cell-mediated GB GB
e. Adult and neonatal GB GB
ANS: D G B
Both B and T lymphocytes are principal components of adaptive immunity. B lympho
GB GB GB GB GB GB GB GB GB GB GB GB
cytes produce antibodies, which are the recognition and effector molecules of humoral
GB GB GB GB GB GB GB GB GB GB GB
immune responses to extracellular pathogens. T cells recognize and promote eradicati
GB GB GB GB GB GB GB GB GB GB GB
on of intracellular pathogens in cell-
GB GB GB GB GB
mediated immunity. Passive and active immunity both can be mediated by either B or
GB GB GB GB GB GB GB GB GB GB GB GB GB G
BT lymphocytes. Specific immunity is another term for adaptive immunity. Both B and
GB GB GB GB GB GB GB GB GB GB GB GB G
BT lymphocytes participate in adult adaptive immunity but are still developing in the
GB GB GB GB GB GB GB GB GB GB GB GB GB
neonatal period. GB
5. The two major functional classes of effector T lymphocytes are:
GB GB GB GB GB GB GB GB GB
a. Helper T lymphocytes and cytotoxic T lymphocytes
GB GB GB GB GB GB
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
GB cyStes GB GB GB
c. Memory T cells and effector T cells GB GB GB GB GB GB
d. Helper cells and antigen-presenting cells
GB GB GB GB
e. Cytotoxic T lymphocytes and target cells GB GB GB GB GB
ANS: A G B
T cells can be classified into effector subsets that perform different effector functions.
GB GB GB GB GB GB GB GB GB GB GB GB G
Most effector T cells are either helper T lymphocytes, which enhance the responses
B GB GB GB GB GB GB GB GB GB GB GB GB GB
of other immune cells, including phagocytes and B cells, to infections, or cytotoxic
GB GB GB GB GB GB GB GB GB GB GB GB GB
T lymphocytes, which directly kill infected cells. Natural killer cells are not T lymp
GB GB GB GB GB GB GB GB GB GB GB GB GB
hocytes.
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells.
GB GB GB GB GB GB GB GB GB GB GB GB GB GB
6. Which of the following cell types is required for all adaptive humoral immune responses?
GB GB GB GB GB GB GB GB GB GB GB GB GB
a. Natural killer cells GB GB
b. Dendritic cells GB
c. Cytolytic T lymphocytes GB GB
d. B lymphocytes GB
e. Helper T lymphocytes GB GB
ANS: D G B
Humoral immune responses are antibody-
GB GB GB GB
mediated immune responses, and all antibodies are made by B lymphocytes and no
GB GB GB GB GB GB GB GB GB GB GB GB
other cell type.
GB GB GB
