NR565 Week 4 Midterm Exam 2025 | NR-565 Advanced
Pharmacology Fundamentals Exam 100 Questions and Answers
Latest 2025/2026 100% Pass Guaranteed Graded A+
A patient with heart failure cannot tolerate angiotensin-converting enzyme
inhibitors (ACEls) due to intractable cough. What alternative therapy can be
considered for this patient?
A. Aldosterone antagonists
B. Beta blockers
C. Loop diuretics
D. Angiotensin receptor blockers (ARBs)
For which condition is celecoxib (Celebrex) primarily indicated?
A. Osteoarthritis
B. Multiple sclerosis (MS)
C. Migraine headache
D. Muscular dystrophy (MD)
What questions should be considered to determine drug responsibility?
A. Evaluating symptoms without discontinuation
B. Ignoring the temporal relationship
C. Considering other drugs in the regime
D. Only considering the underlying illness
What is selectivity in drug action?
A. The ability of a drug to have no side effects
B. The ability of a drug to elicit only the desired response
C. The ability of a drug to produce many sides effects
D. The ability of a drug to work for any condition
A pregnant woman has been regularly using opioids, and the infant is born with signs
of withdrawal. What is the primary concern for the newborn?
A. Elevated risk of infectious diseases
B. Potential for neurological deficits
C. Physical dependence and withdrawal
D. Increased risk of asthma
A patient with gout is prescribed a drug to increase the excretion of uric acid.
Which of the medication is classified as a uricosuric agent?
A. Pegloticase
B. Allopurinol
C. Colchicine
D. Probencid
In an outpatient setting, what is the primary pharmacological action of naloxone
(Narcan) when administered to a patient experiencing opioid overdose?
A. Producing respiratory depression
B. Rapidly reversing opioid poising
C. Causing gastrointestinal hyperactivity
1 | NR565 Week 4 Midterm Exam 2025
, D. Inducing euphoria.
Which class of drugs is the preferred initial therapy for baseline anginal management,
especially in patients with a prior MI, due to its mortality benefits?
A. Angiotensin receptor blockers
B. Beta blockers
C. Calcium channel blockers
D. Long-acting nitrates
When educating a patient about taking bisphosphonates for osteoporosis, which statement made
by the patient demonstrates that more education is needed?
A. "I will not take any antacids, calcium products, or mineral supplements for at least 2
hours after taking the medication".
B. "I will take this medication on an empty stomach first thing in the morning."
C. "I will take medication at night right before I lay down to bed."
D. "I will remain sitting upright for at least 30 minutes after taking the medication."
When prescribing opioids the APRN should
A. Prescribe opioids and benzodiazepines concurrently
B. Start opioid dose at the highest effective dose
C. Use immediate release opioids when initiating treatment.
D. Order a urine drug screen 30 days after initiating treatment
2 | NR565 Week 4 Midterm Exam 2025
, What effect do beta (B) blockers have on patients with heart failure?
A. Promotion of excessive sympathetic stimulation
B. Improved LV ejection fraction
C. Rapid progression of heart failure
D. Increase in contractility
According to the Beers criteria, which NSAID carries the greatest risk of all
NSAIDS for patients aged 56 years and older?
A. Indomethacin
B. Naproxen
C. Diclofenac sodium
D. Celecoxib
Why is respiratory depression a significant concern in the case of fentanyl
overdose?
A. Fentanyl is a strong opioid analgesic
B. Fentanyl causes hypotension
C. Fentanyl is metabolized by CYP3A4
D. Fentanyl has a long duration of action
Why is cyclosporine reserved for severe, progressive rheumatoid arthritis that has
not responded to safer DMARDs?
A. It has a faster onset of action
B. It is effective in mild cases of rheumatoid arthritis
C. It can cause kidney damage
D. It is more cost-effective
What is the major adverse effect associated with the inhibition of COX-1 by first-
generation nonsteroidal ant-inflammatory drugs (NSAIDs)?
A. Renal vasodilation
B. Thromboembolism
C. Gastric erosion and ulceration
D. hypertension
Which term refers to the combined processes of metabolism and excretion of drugs
from the body?
A. Excretion
B. Distribution
C. Elimination
D. Absorption
Which drug is a Tell activation inhibitor and is used to reduce symptoms and delay
disease progression in adults with moderately to severely active rheumatoid
arthritis (RA)?
A. Sanlumab (Kevzara)
B. Tocilizumab (Actemra)
C. Abatacept (Orencia)
D. Etanercept (Enbrel)
What is the primary mechanism of action of nitroglycerin?
A. Increasing coronary blood flow to ischemic areas
3 | NR565 Week 4 Midterm Exam 2025
Pharmacology Fundamentals Exam 100 Questions and Answers
Latest 2025/2026 100% Pass Guaranteed Graded A+
A patient with heart failure cannot tolerate angiotensin-converting enzyme
inhibitors (ACEls) due to intractable cough. What alternative therapy can be
considered for this patient?
A. Aldosterone antagonists
B. Beta blockers
C. Loop diuretics
D. Angiotensin receptor blockers (ARBs)
For which condition is celecoxib (Celebrex) primarily indicated?
A. Osteoarthritis
B. Multiple sclerosis (MS)
C. Migraine headache
D. Muscular dystrophy (MD)
What questions should be considered to determine drug responsibility?
A. Evaluating symptoms without discontinuation
B. Ignoring the temporal relationship
C. Considering other drugs in the regime
D. Only considering the underlying illness
What is selectivity in drug action?
A. The ability of a drug to have no side effects
B. The ability of a drug to elicit only the desired response
C. The ability of a drug to produce many sides effects
D. The ability of a drug to work for any condition
A pregnant woman has been regularly using opioids, and the infant is born with signs
of withdrawal. What is the primary concern for the newborn?
A. Elevated risk of infectious diseases
B. Potential for neurological deficits
C. Physical dependence and withdrawal
D. Increased risk of asthma
A patient with gout is prescribed a drug to increase the excretion of uric acid.
Which of the medication is classified as a uricosuric agent?
A. Pegloticase
B. Allopurinol
C. Colchicine
D. Probencid
In an outpatient setting, what is the primary pharmacological action of naloxone
(Narcan) when administered to a patient experiencing opioid overdose?
A. Producing respiratory depression
B. Rapidly reversing opioid poising
C. Causing gastrointestinal hyperactivity
1 | NR565 Week 4 Midterm Exam 2025
, D. Inducing euphoria.
Which class of drugs is the preferred initial therapy for baseline anginal management,
especially in patients with a prior MI, due to its mortality benefits?
A. Angiotensin receptor blockers
B. Beta blockers
C. Calcium channel blockers
D. Long-acting nitrates
When educating a patient about taking bisphosphonates for osteoporosis, which statement made
by the patient demonstrates that more education is needed?
A. "I will not take any antacids, calcium products, or mineral supplements for at least 2
hours after taking the medication".
B. "I will take this medication on an empty stomach first thing in the morning."
C. "I will take medication at night right before I lay down to bed."
D. "I will remain sitting upright for at least 30 minutes after taking the medication."
When prescribing opioids the APRN should
A. Prescribe opioids and benzodiazepines concurrently
B. Start opioid dose at the highest effective dose
C. Use immediate release opioids when initiating treatment.
D. Order a urine drug screen 30 days after initiating treatment
2 | NR565 Week 4 Midterm Exam 2025
, What effect do beta (B) blockers have on patients with heart failure?
A. Promotion of excessive sympathetic stimulation
B. Improved LV ejection fraction
C. Rapid progression of heart failure
D. Increase in contractility
According to the Beers criteria, which NSAID carries the greatest risk of all
NSAIDS for patients aged 56 years and older?
A. Indomethacin
B. Naproxen
C. Diclofenac sodium
D. Celecoxib
Why is respiratory depression a significant concern in the case of fentanyl
overdose?
A. Fentanyl is a strong opioid analgesic
B. Fentanyl causes hypotension
C. Fentanyl is metabolized by CYP3A4
D. Fentanyl has a long duration of action
Why is cyclosporine reserved for severe, progressive rheumatoid arthritis that has
not responded to safer DMARDs?
A. It has a faster onset of action
B. It is effective in mild cases of rheumatoid arthritis
C. It can cause kidney damage
D. It is more cost-effective
What is the major adverse effect associated with the inhibition of COX-1 by first-
generation nonsteroidal ant-inflammatory drugs (NSAIDs)?
A. Renal vasodilation
B. Thromboembolism
C. Gastric erosion and ulceration
D. hypertension
Which term refers to the combined processes of metabolism and excretion of drugs
from the body?
A. Excretion
B. Distribution
C. Elimination
D. Absorption
Which drug is a Tell activation inhibitor and is used to reduce symptoms and delay
disease progression in adults with moderately to severely active rheumatoid
arthritis (RA)?
A. Sanlumab (Kevzara)
B. Tocilizumab (Actemra)
C. Abatacept (Orencia)
D. Etanercept (Enbrel)
What is the primary mechanism of action of nitroglycerin?
A. Increasing coronary blood flow to ischemic areas
3 | NR565 Week 4 Midterm Exam 2025
