EDMUNDS’ PHARMACOLOGY FOR THE
PRIMARY CARE PROVIDER EXAMINATION TEST
2026 FULL QUESTIONS AND ANSWERS
GRADED A+
◉ What is distribution of a medication? Answer: how displaced in
the body
◉ What drug characteristics affect absorption? Answer: molecular
weight, ionization, solubility, and formulation
◉ What factors affect drug absorption related to the patient?
Answer: route, gastric pH, contents of GI tract
◉ What is membrane permeability? Answer: How the drug crosses
membranes to site of action
◉ What is plasma protein binding? Answer: Bound drugs do not
cross membranes when they are highly protein bound
◉ How does malnutrition affect medications distribution in the body
of drugs that are highly protein bound? Answer: malnutrition means
low albumin, less drug is bound and more free drug in system
, ◉ What is lipophilicity of a drug? Answer: lipophilic drugs
accumulate in adipose tissue
◉ What is volume of distribution? Answer: how drug is transported
◉ Where can drugs undergo metabolism? Answer: lungs, liver, blood
◉ What is the body's natural response to a drug and why? Answer:
Works to convert drugs to less active forms and increase water
solubility to enhance elimination; drugs and toxins are seen as
foreign to the body
◉ Where is the primary route of drug metabolism? What is the main
pathway there? Answer: liver; cytochrome P450
◉ Where is the cytochrome P450 system located? How are drugs
metabolized there? Answer: Within the ER of hepatocytes; drug is
bound to it through electron transport chain and then either
oxidized or reduced
◉ What is a Phase I reaction of drug metabolism? What different
processes does it involve? Answer: Ctyochrome P450; hydrolysis,
oxidation, reduction, demethylation, methylation, alcohol
dehydrogenase metabolism
PRIMARY CARE PROVIDER EXAMINATION TEST
2026 FULL QUESTIONS AND ANSWERS
GRADED A+
◉ What is distribution of a medication? Answer: how displaced in
the body
◉ What drug characteristics affect absorption? Answer: molecular
weight, ionization, solubility, and formulation
◉ What factors affect drug absorption related to the patient?
Answer: route, gastric pH, contents of GI tract
◉ What is membrane permeability? Answer: How the drug crosses
membranes to site of action
◉ What is plasma protein binding? Answer: Bound drugs do not
cross membranes when they are highly protein bound
◉ How does malnutrition affect medications distribution in the body
of drugs that are highly protein bound? Answer: malnutrition means
low albumin, less drug is bound and more free drug in system
, ◉ What is lipophilicity of a drug? Answer: lipophilic drugs
accumulate in adipose tissue
◉ What is volume of distribution? Answer: how drug is transported
◉ Where can drugs undergo metabolism? Answer: lungs, liver, blood
◉ What is the body's natural response to a drug and why? Answer:
Works to convert drugs to less active forms and increase water
solubility to enhance elimination; drugs and toxins are seen as
foreign to the body
◉ Where is the primary route of drug metabolism? What is the main
pathway there? Answer: liver; cytochrome P450
◉ Where is the cytochrome P450 system located? How are drugs
metabolized there? Answer: Within the ER of hepatocytes; drug is
bound to it through electron transport chain and then either
oxidized or reduced
◉ What is a Phase I reaction of drug metabolism? What different
processes does it involve? Answer: Ctyochrome P450; hydrolysis,
oxidation, reduction, demethylation, methylation, alcohol
dehydrogenase metabolism
