Clinical Aspects of Inflammation 9/26
1. systemic changes of acute phase response: fever
acute phase proteins
leukocytosis
2. what is acute phase response triggered by: trauma
inflection
stress
neoplasia
inflammation
3. what is the acute phase response mediated by: IL1
IL6
TNFa
IFNy
4. serum protein concentration change in acute phase response: by around 25%,
synthesized in liver and mediates innate immune response
5. what does change in serum protein concentration cause: behavioral changes
fever
1/5
, leukocytosis
6. what organs does acute phase response cytkines impact: brain and liver
7. what else impacts the liver in acute phase response: hypothalamus increases release of
CRH, which increases release of ACTH by anterior pituitary, which affects adrenals to produce glucocorticoids which
impact liver
8. acute phase response proteins: C reactive protein
serum amyloid protein
mannose binding lectin
a-2 macroglobulin
proteins that reduce iron availability
a1-anti trypsin and a1 anti-chymotrypsin
coagulation protein s
complement proteins
9. what is C reactive protein produced by: liver; nonspecific marker of inflammation
10. what does C reactive protein recognize: altered self and foreign molecules based on pattern
recognition; binds to cell walls of bacteria and fungi
2/5
1. systemic changes of acute phase response: fever
acute phase proteins
leukocytosis
2. what is acute phase response triggered by: trauma
inflection
stress
neoplasia
inflammation
3. what is the acute phase response mediated by: IL1
IL6
TNFa
IFNy
4. serum protein concentration change in acute phase response: by around 25%,
synthesized in liver and mediates innate immune response
5. what does change in serum protein concentration cause: behavioral changes
fever
1/5
, leukocytosis
6. what organs does acute phase response cytkines impact: brain and liver
7. what else impacts the liver in acute phase response: hypothalamus increases release of
CRH, which increases release of ACTH by anterior pituitary, which affects adrenals to produce glucocorticoids which
impact liver
8. acute phase response proteins: C reactive protein
serum amyloid protein
mannose binding lectin
a-2 macroglobulin
proteins that reduce iron availability
a1-anti trypsin and a1 anti-chymotrypsin
coagulation protein s
complement proteins
9. what is C reactive protein produced by: liver; nonspecific marker of inflammation
10. what does C reactive protein recognize: altered self and foreign molecules based on pattern
recognition; binds to cell walls of bacteria and fungi
2/5
