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Exam (elaborations)

NSG 5140 Midterm Exam 2025: Advanced Pathophysiology Study Guide & Practice Test

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Prepare for your NSG 5140 Advanced Pathophysiology midterm with this essential 2025 exam guide. Includes key topics, potential essay questions, and practice tests to master cellular dysfunction, fluid and electrolytes, and systemic disorders for nurse practitioners.

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Uploaded on
November 3, 2025
Number of pages
51
Written in
2025/2026
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NSG 5140 Midterm Exam Newest 2025 / NSG 5140
Adv Pathophysiology SOUTH COLLEGE Complete
Questions And Correct Detailed Answers (Verified
Answers) |Already Graded A+


Sodium-Potassium Pump - . . ANSWER ✔ ✔The sodium-
potassium pump moves 3 Na⁺ ions out and 2 K⁺ ions into
the cell, creating an electrochemical gradient essential for
membrane potential.


Mitochondria - . . ANSWER ✔ ✔Mitochondria are known
as the 'powerhouse' of the cell due to their role in oxidative
phosphorylation and ATP generation.


Metabolic Acidosis Lab Values - . . ANSWER ✔ ✔In
metabolic acidosis, there is a loss of bicarbonate or
accumulation of acids, lowering both bicarbonate and pH.


B Lymphocytes - . . ANSWER ✔ ✔B cells differentiate into
plasma cells which produce antibodies, central to humoral
immunity.

,2|Page


Hallmark of Reversible Cellular Injury - . . ANSWER ✔
✔Reversible injury often involves failure of ion pumps
leading to water influx and cell swelling.


Interleukin-1 (IL-1) - . . ANSWER ✔ ✔IL-1 acts on the
hypothalamus to raise the body temperature set point,
causing fever.


Type 1 Diabetes Mellitus - . . ANSWER ✔ ✔Type 1 DM is
an autoimmune condition where T-cells destroy insulin-
producing beta cells in the pancreas.


Cardinal Sign of Acute Inflammation - . . ANSWER ✔
✔Redness (rubor) results from vasodilation and increased
blood flow to the inflamed area.


Down Syndrome - . . ANSWER ✔ ✔Trisomy 21 leads to
Down syndrome, characterized by developmental delays
and distinct facial features.

,3|Page


Liquefactive Necrosis - . . ANSWER ✔ ✔In the brain,
ischemic injury leads to enzymatic digestion of dead cells
resulting in liquefactive necrosis.


IgM - . . ANSWER ✔ ✔IgM is the first antibody produced
and is effective in agglutination and complement
activation.


Oncogene - . . ANSWER ✔ ✔Oncogenes are mutated
proto-oncogenes that drive unregulated cell proliferation.


Hypokalemia - . . ANSWER ✔ ✔Low potassium levels
disturb the cardiac action potential, increasing the risk of
arrhythmias.


Type III Hypersensitivity - . . ANSWER ✔ ✔SLE involves
immune complex deposition (Type III), leading to
widespread inflammation and tissue damage.


Frontal Lobe - . . ANSWER ✔ ✔The primary motor cortex,
located in the frontal lobe, initiates voluntary movement.

, 4|Page


Impaired tissue perfusion - . . ANSWER ✔ ✔Shock results
in inadequate delivery of oxygen and nutrients to tissues,
causing cellular dysfunction.


Bronchoconstriction and mucus production - . . ANSWER
✔ ✔Asthma involves hyperresponsiveness, smooth muscle
constriction, and increased mucus, narrowing the airway.


Apoptosis - . . ANSWER ✔ ✔Apoptosis is an orderly
process for removing damaged or unneeded cells without
inflammation.


Atherosclerotic plaque rupture - . . ANSWER ✔ ✔Plaque
rupture leads to thrombus formation, blocking coronary
arteries and causing infarction.


Serum creatinine - . . ANSWER ✔ ✔Creatinine is a waste
product filtered by the kidneys; elevated levels suggest
impaired renal function.


Aldosterone - . . ANSWER ✔ ✔Aldosterone promotes Na⁺
reabsorption and K⁺ loss in the distal nephron to increase
blood volume.
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