MRCP 1 - PHARMACOLOGY COMPREHENSIVE EXAM
QUESTIONS WITH DETAILED VERIFIED AND 100%
ACCURATE ANSWERS BRAND NEW EXAM ALREADY
GRADED A+ PASS
Oculogyric crisis (Dystonia) -
reaction to drugs, in particular neuroleptics and dopaminergic
medications (classically metoclopramide and haloperidol)
Ans✓✓✓agitated, has a clenched jaw and her eyes are deviated
upwards.(Oculogyric crisis)
℞: IV antimuscarinic: benztropine or procyclidine
Calcium channel blockers adverse effects Ans✓✓✓⛑Headache
⛑ Flushing
⛑ Ankle oedema
⛑Verapamil also commonly causes constipation⛑
beta blockers adverse effects Ans✓✓✓⛑Bronchospasm (especially in
asthmatics)
⛑ Fatigue
⛑ Cold peripheries
⛑ Sleep disturbances
Methanol poisoning
,causes both the effects associated with alcohol (intoxication, nausea etc)
and also specific visual problems, including blindness. These effects are
thought to be secondary to the accumulation of formic acid.
℞: fomepizole (competitive inhibitor of alcohol dehydrogenase) or
ethanol Ans✓✓✓Methanol poisoning
causes both the effects associated with alcohol (intoxication, nausea etc)
and also specific visual problems, including blindness. These effects are
thought to be secondary to the accumulation of formic acid.
℞: fomepizole (competitive inhibitor of alcohol dehydrogenase) or
ethanol
Ethylene glycol toxicity
Ethylene glycol is a type of alcohol used as a coolant or antifreeze.
Features of toxicity are divided into 3 stages:
Stage 1: symptoms similar to alcohol intoxication: confusion, slurred
speech, dizziness
Stage 2: metabolic acidosis with high anion gap and high osmolar gap.
Also tachycardia, hypertension
Stage 3: acute kidney injury
,℞: fomepizole, an inhibitor of alcohol dehydrogenase, is now used first-
line in preference to ethanol Ans✓✓✓Ethylene glycol toxicity
Ethylene glycol is a type of alcohol used as a coolant or antifreeze.
Features of toxicity are divided into 3 stages:
Stage 1: symptoms similar to alcohol intoxication: confusion, slurred
speech, dizziness
Stage 2: metabolic acidosis with high anion gap and high osmolar gap.
Also tachycardia, hypertension
Stage 3: acute kidney injury
℞: fomepizole, an inhibitor of alcohol dehydrogenase, is now used first-
line in preference to ethanol
Acute intermittent porphyria
autosomal dominant - caused by a defect in porphobilinogen deaminase,
an enzyme involved in the biosynthesis of haem. Ans✓✓✓What disease
causes port-wine colored urine, polyneuropathy and painful abdomen?
Drugs which may precipitate attack
barbiturates
halothane
benzodiazepines
, alcohol
oral contraceptive pill
sulphonamides
acute intermittent porphyria is brought to the Emergency Department by
the police due to an acute psychosis.
What is the most suitable drug for sedation? Ans✓✓✓Chlorpromazine is
considered safe to use in patients with acute intermittent porphyria.
Adrenaline induces
⬆ High sugar
⬆ High Lactate
⬇ Low K .
causes vasoconstriction in the skin and kidneys causing a narrow pulse
pressure Ans✓✓✓Adrenaline induces
⬆ High sugar
⬆ High Lactate
⬇ Low K .
causes vasoconstriction in the skin and kidneys causing a narrow pulse
pressure
QUESTIONS WITH DETAILED VERIFIED AND 100%
ACCURATE ANSWERS BRAND NEW EXAM ALREADY
GRADED A+ PASS
Oculogyric crisis (Dystonia) -
reaction to drugs, in particular neuroleptics and dopaminergic
medications (classically metoclopramide and haloperidol)
Ans✓✓✓agitated, has a clenched jaw and her eyes are deviated
upwards.(Oculogyric crisis)
℞: IV antimuscarinic: benztropine or procyclidine
Calcium channel blockers adverse effects Ans✓✓✓⛑Headache
⛑ Flushing
⛑ Ankle oedema
⛑Verapamil also commonly causes constipation⛑
beta blockers adverse effects Ans✓✓✓⛑Bronchospasm (especially in
asthmatics)
⛑ Fatigue
⛑ Cold peripheries
⛑ Sleep disturbances
Methanol poisoning
,causes both the effects associated with alcohol (intoxication, nausea etc)
and also specific visual problems, including blindness. These effects are
thought to be secondary to the accumulation of formic acid.
℞: fomepizole (competitive inhibitor of alcohol dehydrogenase) or
ethanol Ans✓✓✓Methanol poisoning
causes both the effects associated with alcohol (intoxication, nausea etc)
and also specific visual problems, including blindness. These effects are
thought to be secondary to the accumulation of formic acid.
℞: fomepizole (competitive inhibitor of alcohol dehydrogenase) or
ethanol
Ethylene glycol toxicity
Ethylene glycol is a type of alcohol used as a coolant or antifreeze.
Features of toxicity are divided into 3 stages:
Stage 1: symptoms similar to alcohol intoxication: confusion, slurred
speech, dizziness
Stage 2: metabolic acidosis with high anion gap and high osmolar gap.
Also tachycardia, hypertension
Stage 3: acute kidney injury
,℞: fomepizole, an inhibitor of alcohol dehydrogenase, is now used first-
line in preference to ethanol Ans✓✓✓Ethylene glycol toxicity
Ethylene glycol is a type of alcohol used as a coolant or antifreeze.
Features of toxicity are divided into 3 stages:
Stage 1: symptoms similar to alcohol intoxication: confusion, slurred
speech, dizziness
Stage 2: metabolic acidosis with high anion gap and high osmolar gap.
Also tachycardia, hypertension
Stage 3: acute kidney injury
℞: fomepizole, an inhibitor of alcohol dehydrogenase, is now used first-
line in preference to ethanol
Acute intermittent porphyria
autosomal dominant - caused by a defect in porphobilinogen deaminase,
an enzyme involved in the biosynthesis of haem. Ans✓✓✓What disease
causes port-wine colored urine, polyneuropathy and painful abdomen?
Drugs which may precipitate attack
barbiturates
halothane
benzodiazepines
, alcohol
oral contraceptive pill
sulphonamides
acute intermittent porphyria is brought to the Emergency Department by
the police due to an acute psychosis.
What is the most suitable drug for sedation? Ans✓✓✓Chlorpromazine is
considered safe to use in patients with acute intermittent porphyria.
Adrenaline induces
⬆ High sugar
⬆ High Lactate
⬇ Low K .
causes vasoconstriction in the skin and kidneys causing a narrow pulse
pressure Ans✓✓✓Adrenaline induces
⬆ High sugar
⬆ High Lactate
⬇ Low K .
causes vasoconstriction in the skin and kidneys causing a narrow pulse
pressure
