NR566 Final Exam Questions and Answers(Advanced Pharmacology for Care of the Family)

NR566 Final (Advanced Pharmacology
for Care of the Family)

Anti-Androgens - Answer-Finasteride (Propecia)

Leuprolide (Eligard, Lupron, Lupron Depot)

Spironolactone (Aldactone)



Finasteride (Propecia, Proscar) - Answer-blocks conversion of testosterone to dihydrotesterone



Used to tx:

-BPH

-male pattern baldness

3 months of therapy need to see benefits

Stopping, reverses effect w/in 12 months



Adverse side effects:

- Decreased libido

-Impotence



dutasteride (Avodart) - Answer-5-alpha reductase inhibitor

used to tx:

BPH



Can stay in serum up to 6 mon after discontinuing

,can be absorbed through skin

pregnant woman shouldn't handle capsules

(fetal anomaly in male fetus)



Adverse Effects

decreased libido

Impotence



Leuprolide Acetate (Lupron) - Answer-Luteinizing hormone - releasing agonist

create reversible:

-orchiectomy state

-oophorectomy state



Used to tx:

- advanced prostatic cancer

- Management of endometriosis

- Uterine fibroids

- polycystic ovarian disease

- central precocious puberty in peds



Flutamide (Eulexin, Euflex) - Answer-Truly non-steroidal agent

Used to tx:

-Advanced prostate cancer

-female androgen excess syndrome

, Adverse Effects in males

- gynecomastia

-reversible liver toxicity



Black Box Warning

-hepatic failure

-hepatic encephalopathy

Basline/monthly liver function test for 1st 4 months



Spironolactone (Aldactone) - Answer-aldosterone antagonist

potassium sparing diuretic



used for tx:

-female hirsutism (abnormal growth of hair)

-acne

-relief of PMS/PMDD symptoms (25-50 mg/d)



Adverse reactions

- dose related + reversible when discont.

-GI upset

-Drowsiness

-Gynecomastia

-Impotence

-Cutaneous (skin) eruptions