Page 1 of 301 | | |
APHA NAPLEX REVIEW 2025-2026 BRAND NEW
ACTUAL EXAM WITH 100% VERIFIED
QUESTIONS AND CORRECT SOLUTIONS
1. Which of the following is a drug of choice for Rickettsia infx such as
| | | | | | | | | | | | |
rocky mountain spotted fever?
| | | |
A. clindamycin
B. doxycycline
C. azithromycin
D. rifaximin - correct answer - B. Doxycycline is a drug of choice for
| | | | | | | | | | | |
tick-borne illnesses such as Lyme dx and Rocky mountain spotted
| | | | | | | | | |
fever
|
2. Which of the following drugs could adequately treat a skin and ssti
| | | | | | | | | | |
caused by CA-MRSA?
| | |
A. metronidazole
B. fidaxomicin
C. colistimethate
D. bactrim - correct answer - D. The three antibiotics commonly used to
| | | | | | | | | | |
treat CA-MRSA and SSTI are doxycycline, clindamycin, and
| | | | | | | |
bactrim
|
, Page 2 of 301 | | |
3. Which of the following abx may have a higher incidence of predisposing a
| | | | | | | | | | | |
pt for a C. diff infection?
| | | | | |
A. clindamycin
B. fidaxomicin
C. metronidazole
D. oral vancomycin - correct answer - A. Although all antibiotics can
| | | | | | | | | |
cause C.diff, clincadymcin's spectrum of activity covers many
| | | | | | | |
anaerobes except for C.diff. For this reason, it is commonly
| | | | | | | | | |
implicated as a predisposition for C. diff infx
| | | | | | | |
4. Which of the following agents has the best activity against the gram-
| | | | | | | | | | |
negative anaerobe Bacteroides fragilis?
| | | |
A. clindamycin
B. colistin
C. fidaxomicin
D. metronidazole - correct answer - D. Metronidazole displays a purely | | | | | | | | |
anaerobic spectrum of activity and is the drug of choice for one of the
| | | | | | | | | | | | | |
main gram negative anaerobes B. fragilis typically located in the lower
| | | | | | | | | | |
GI
|
5. Which of the following drugs is used only for severe infx caused by MDR
| | | | | | | | | | | | |
pathogens due to a significant risk of nephrotoxicity
| | | | | | | |
A. rifaximin
B. colistin
C. clindamycin
, Page 3 of 301 | | |
D. fidaxomicin - correct answer - B. Colistin is a polymyxin antibiotic
| | | | | | | | | |
that can be used for MDR gram negative pathogens such as P.
| | | | | | | | | | | |
aeruginosa and Acinetobacter spp. Its main limiting effect is
| | | | | | | | |
significant nephrotoxicity, and it should be reserved for severe or
| | | | | | | | | |
MDR infx
| |
6. Which of the following antifungal agents is the drug of choice for
| | | | | | | | | | |
infections caused by candida albicans?
| | | | |
A. terbinafine
B. fluconazole
C. flucytosine
D. griseofulvin - correct answer - B. Fluconazole is a drug of choice for
| | | | | | | | | | | |
C. albicans, yet it does not cover some non-Candida albicans species
| | | | | | | | | |
including C. glabrata or C. krusei. Although fluconazole can display
| | | | | | | | | |
dose-dependent susceptibility for some C. glabrata, it is inherently
| | | | | | | | |
resistant to C. krusei
| | | |
7. Which of the following well-tolerated antifungal agents is commonly used to
| | | | | | | | | |
treat disseminated candidiasis caused by Candida krusei?
| | | | | | |
A. caspofungin
B. ampho B |
C. posaconazole
D. fluconazole - correct answer - A. Echinocandins are drugs of choice
| | | | | | | | | |
for disseminated candidiasis caused by non-albicans or fluconazole-
| | | | | | | |
resistant Candida spx. Echinocandins are often initiated as empiric
| | | | | | | | |
therapy for disseminated candidiasis until the fungal spx is known by
| | | | | | | | | | |
culture
|
, Page 4 of 301 | | |
8. Which of the following oral antifungal medications is commonly used to
| | | | | | | | | |
treat onychomycosis?
| |
A. ampho B |
B. caspofungin
C. posaconazole
D. terbinafine - correct answer - D. Terbinafine is an oral antifungal
| | | | | | | | | |
agent that is commonly used to treat dermatophytes that cause
| | | | | | | | | |
onychomycosis
|
9. Which of the following antitubercular agents is the drug of choice for
| | | | | | | | | | |
latent TB infection?
| | |
A. isoniazid
B. cycloserine
C. ethambutol
D. capreomycin - correct answer - A. Isoniazid daily therapy is the
| | | | | | | | | |
preferred regimen for latent TB infx. Pts should be supplemented w/
| | | | | | | | | | |
pyridoxine and should avoid alcoholic beverages while taking
| | | | | | | |
isoniazid
|
10. Which of the following agents can cause red-colored staining of body
| | | | | | | | | |
fluids
|
A. rifampin
B. isoniazid
C. pyrazinamide
APHA NAPLEX REVIEW 2025-2026 BRAND NEW
ACTUAL EXAM WITH 100% VERIFIED
QUESTIONS AND CORRECT SOLUTIONS
1. Which of the following is a drug of choice for Rickettsia infx such as
| | | | | | | | | | | | |
rocky mountain spotted fever?
| | | |
A. clindamycin
B. doxycycline
C. azithromycin
D. rifaximin - correct answer - B. Doxycycline is a drug of choice for
| | | | | | | | | | | |
tick-borne illnesses such as Lyme dx and Rocky mountain spotted
| | | | | | | | | |
fever
|
2. Which of the following drugs could adequately treat a skin and ssti
| | | | | | | | | | |
caused by CA-MRSA?
| | |
A. metronidazole
B. fidaxomicin
C. colistimethate
D. bactrim - correct answer - D. The three antibiotics commonly used to
| | | | | | | | | | |
treat CA-MRSA and SSTI are doxycycline, clindamycin, and
| | | | | | | |
bactrim
|
, Page 2 of 301 | | |
3. Which of the following abx may have a higher incidence of predisposing a
| | | | | | | | | | | |
pt for a C. diff infection?
| | | | | |
A. clindamycin
B. fidaxomicin
C. metronidazole
D. oral vancomycin - correct answer - A. Although all antibiotics can
| | | | | | | | | |
cause C.diff, clincadymcin's spectrum of activity covers many
| | | | | | | |
anaerobes except for C.diff. For this reason, it is commonly
| | | | | | | | | |
implicated as a predisposition for C. diff infx
| | | | | | | |
4. Which of the following agents has the best activity against the gram-
| | | | | | | | | | |
negative anaerobe Bacteroides fragilis?
| | | |
A. clindamycin
B. colistin
C. fidaxomicin
D. metronidazole - correct answer - D. Metronidazole displays a purely | | | | | | | | |
anaerobic spectrum of activity and is the drug of choice for one of the
| | | | | | | | | | | | | |
main gram negative anaerobes B. fragilis typically located in the lower
| | | | | | | | | | |
GI
|
5. Which of the following drugs is used only for severe infx caused by MDR
| | | | | | | | | | | | |
pathogens due to a significant risk of nephrotoxicity
| | | | | | | |
A. rifaximin
B. colistin
C. clindamycin
, Page 3 of 301 | | |
D. fidaxomicin - correct answer - B. Colistin is a polymyxin antibiotic
| | | | | | | | | |
that can be used for MDR gram negative pathogens such as P.
| | | | | | | | | | | |
aeruginosa and Acinetobacter spp. Its main limiting effect is
| | | | | | | | |
significant nephrotoxicity, and it should be reserved for severe or
| | | | | | | | | |
MDR infx
| |
6. Which of the following antifungal agents is the drug of choice for
| | | | | | | | | | |
infections caused by candida albicans?
| | | | |
A. terbinafine
B. fluconazole
C. flucytosine
D. griseofulvin - correct answer - B. Fluconazole is a drug of choice for
| | | | | | | | | | | |
C. albicans, yet it does not cover some non-Candida albicans species
| | | | | | | | | |
including C. glabrata or C. krusei. Although fluconazole can display
| | | | | | | | | |
dose-dependent susceptibility for some C. glabrata, it is inherently
| | | | | | | | |
resistant to C. krusei
| | | |
7. Which of the following well-tolerated antifungal agents is commonly used to
| | | | | | | | | |
treat disseminated candidiasis caused by Candida krusei?
| | | | | | |
A. caspofungin
B. ampho B |
C. posaconazole
D. fluconazole - correct answer - A. Echinocandins are drugs of choice
| | | | | | | | | |
for disseminated candidiasis caused by non-albicans or fluconazole-
| | | | | | | |
resistant Candida spx. Echinocandins are often initiated as empiric
| | | | | | | | |
therapy for disseminated candidiasis until the fungal spx is known by
| | | | | | | | | | |
culture
|
, Page 4 of 301 | | |
8. Which of the following oral antifungal medications is commonly used to
| | | | | | | | | |
treat onychomycosis?
| |
A. ampho B |
B. caspofungin
C. posaconazole
D. terbinafine - correct answer - D. Terbinafine is an oral antifungal
| | | | | | | | | |
agent that is commonly used to treat dermatophytes that cause
| | | | | | | | | |
onychomycosis
|
9. Which of the following antitubercular agents is the drug of choice for
| | | | | | | | | | |
latent TB infection?
| | |
A. isoniazid
B. cycloserine
C. ethambutol
D. capreomycin - correct answer - A. Isoniazid daily therapy is the
| | | | | | | | | |
preferred regimen for latent TB infx. Pts should be supplemented w/
| | | | | | | | | | |
pyridoxine and should avoid alcoholic beverages while taking
| | | | | | | |
isoniazid
|
10. Which of the following agents can cause red-colored staining of body
| | | | | | | | | |
fluids
|
A. rifampin
B. isoniazid
C. pyrazinamide
