APHON Principles of Chemo and Biotherapy Exam
PRACTICE QUESTIONS AND CORRECT
VERIFIED ANSWERS (Complete Solutions)
ASSURED SUCCESS | GRADED A+!!! LATEST
2025/2026.
What are Chemotherapy effects on the cell cycle with cell cycle non-specific
drugs? - CORRECT ANSWER-1. Work in any cell phase (even in G0) 2.
Greatest action when administered as a bolus 3. Cytotoxic effects occur when cell
division is attempted
What pediatric chemo drugs are antimetabolite agents? - CORRECT
ANSWERMethotrexate, fluorouracil (5-FU), cytarabine (Ara-C),
Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea
What are common side effects of plant alkaloids? - CORRECT ANSWER-
Peripheral neuropathies, constipation, N&V, diarrhea, amenorrhea, and infertility
Which types of agents are associated with secondary malignancies? - CORRECT
ANSWER-Alkylating agents, plant alkaloids
Which antimetabolite is associated with hepatoportal sclerosis and esophageal
varices? - CORRECT ANSWER-Thioguanine
, Define neoadjuvant chemotherapy - CORRECT ANSWER-When chemo is used
preoperatively to decrease tumor burden in order to make it easier to remove the
tumor surgically.
Define sanctuary sites - CORRECT ANSWER-Sites within the body where
tumor cells sequester and are not easily reached by chemo such as the CNS
Define adjuvant chemotherapy - CORRECT ANSWER-The use of chemo after
another type of therapy, such as surgery, to treat residual disease or undetectable
metastasis.
What normal cells are most often effected by chemotherapy - CORRECT
ANSWER-Hematopoietic, mucosal (mouth & GI), hair follicles
Why use chemotherapy - CORRECT ANSWER-To prevent cancer cells from
dividing, metastasizing, and ultimately causing the death of the patient
Cure - CORRECT ANSWER-To permanently eradicate the cancer
Biotherapy - CORRECT ANSWER-Targeted anticancer agents also known as
biological response modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - CORRECT ANSWER-
Biotherapy
PRACTICE QUESTIONS AND CORRECT
VERIFIED ANSWERS (Complete Solutions)
ASSURED SUCCESS | GRADED A+!!! LATEST
2025/2026.
What are Chemotherapy effects on the cell cycle with cell cycle non-specific
drugs? - CORRECT ANSWER-1. Work in any cell phase (even in G0) 2.
Greatest action when administered as a bolus 3. Cytotoxic effects occur when cell
division is attempted
What pediatric chemo drugs are antimetabolite agents? - CORRECT
ANSWERMethotrexate, fluorouracil (5-FU), cytarabine (Ara-C),
Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea
What are common side effects of plant alkaloids? - CORRECT ANSWER-
Peripheral neuropathies, constipation, N&V, diarrhea, amenorrhea, and infertility
Which types of agents are associated with secondary malignancies? - CORRECT
ANSWER-Alkylating agents, plant alkaloids
Which antimetabolite is associated with hepatoportal sclerosis and esophageal
varices? - CORRECT ANSWER-Thioguanine
, Define neoadjuvant chemotherapy - CORRECT ANSWER-When chemo is used
preoperatively to decrease tumor burden in order to make it easier to remove the
tumor surgically.
Define sanctuary sites - CORRECT ANSWER-Sites within the body where
tumor cells sequester and are not easily reached by chemo such as the CNS
Define adjuvant chemotherapy - CORRECT ANSWER-The use of chemo after
another type of therapy, such as surgery, to treat residual disease or undetectable
metastasis.
What normal cells are most often effected by chemotherapy - CORRECT
ANSWER-Hematopoietic, mucosal (mouth & GI), hair follicles
Why use chemotherapy - CORRECT ANSWER-To prevent cancer cells from
dividing, metastasizing, and ultimately causing the death of the patient
Cure - CORRECT ANSWER-To permanently eradicate the cancer
Biotherapy - CORRECT ANSWER-Targeted anticancer agents also known as
biological response modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - CORRECT ANSWER-
Biotherapy
