Q UE STI O N 1
1. Bortezomib belongs to which drug class?
A Protease inhibitors
.
B Immunomodulators
.
C Tyrosin kinase inhibitors
.
D Topoisomerase inhibitors
.
5 points
Q UE STI O N 2
1. Which of the following monoclonal antibodies targets the CD20 surface antigen on B cells?
A Rituximab
.
B Cetuximab
.
C Nivolumab
.
D Bevacizumab
.
5 points
Q UE STI O N 3
1. Alterations that may occurr in genetics that develop sporatic colorectal cancers may involve these
pathways:
A P53, APC and KRAS
.
B Chromosomal instability or suppressor pathway
.
Microsatilite instability or mutator pathway
CpG island CIMP or serrated pathway
C BRAF gene
.
D MMR deficiency
.
5 points
Q UE STI O N 4
1. Patient started on Vincristine should be counseled to report which of the following side effects?
A Numbness
.
B Cough
.
C Headache
.
D Diarrhea
.
, 5 points
Q UE STI O N 5
1. Aromatase inhibitors are used to treat
ER positive breast cancer in postmenopausal women
Ovarian cancer
HER 2 negative breast cancer
HER 2 positive breast cancer
5 points
Q UE STI O N 6
1. Which agent has both non-oncological and oncological indications?
A Trexall
.
B Ibrutinib
.
C Cisplatin
.
D Docetaxel
.
5 points
Q UE STI O N 7
1. Which of the following Antineoplastic agents can increase a serum concentration of warfarin,
potentially leading to an increased risk of bleeding?
A Casodex
.
B Cytarabine
.
C Bortezomib
.
D Revlimid
.
5 points
Q UE STI O N 8
1. Nolvadex (tamoxifen) works on ER positive breast cancer through:
A Blockage of estrogen receptors and activation of other estrogen receptors in tissues
.
B Inhibition of estrogen synthesis
.
C Blockage of
.
D Blockage of estrogen inducers
.
5 points
Q UE STI O N 9
1. Tamoxifen in a combination with a inhibitor can cause a recurrence of
breast cancer. Drugs to avoid in women taking tamoxifen are and
, CYP2D6, Paxil and Zoloft
CYP2D6, Lexapro and serequil
CYP3D6, Effexor and Zoloft
CYP2D6, Prozac and Cipralex
5 points
Q UE STI O N 10
1. HER 2 positive breast cancer treated with Ado-trastuzumab emtansine (Kadcyla) may be
used in combination with:
A Pertuzumab (Perjeta) and docetaxel
.
B Lapatinib
.
C Tamoxifin
.
D Denosumab
.
5 points
Q UE STI O N 11
1. What class of anti-neoplastic agents typically interact with strong CYP3A4 inhibitors and
inducers?
A Aromatase inhibitors
.
B Tyrosine kinase inhibitors
.
C Monoclonal antibodies
.
D Platinum compounds
.
5 points
Q UE STI O N 12
1. The Karnofsky performance scale is used to assess
A The general health of the patient
.
B The location of the tumor
.
C The grade of the cancer
.
D The responsiveness to chemotherapy of the type of the cancer
.
5 points
Q UE STI O N 13
1. is a rare but serious side effects associated with cisplatin
A Ototoxicity
.
B Cardio toxicity
.
, C Immune mediated pneumonitis
.
D Hypothyroidism
.
5 points
Q UE STI O N 14
1. The management of immune mediated toxicity associated with nivolumab may involve which of
the following?
A Corticosteroids
.
B Full a casted
.
C Leucovorin
.
D Thiamine
.
5 points
Q UE STI O N 15
1. Prophylactic treatment for hyperuricemia is generally prescribed in patients with leukemia and
lymphoma in home hyperuricemia is most likely. Prophylactic treatment of is the
standard of care
Allopurinol
Rasburicase
colchicin
e
NSAIDS
5 points
Q UE STI O N 16
1. Hepatotoxicity is associated with which of the following agents?
Opdivo
Herceptin
Letrozole
Carboplatin
5 points
Q UE STI O N 17
1. A premenopausal woman has ER-positive breast cancer, and her prescriber has
ordered tamoxifen [Nolvadex]. She asks the nurse if anastrozole [Arimidex]
would work better for her. What will the nurse tell her?
A Anastrozole is more likely to cause hot flushes than tamoxifen
.
B Anastrozole is more likely to promote endometrial carcinoma.