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PCCN Practice Questions 2025 (100+ Q&A) – Hemodynamics, Cardiac Drugs, Respiratory Failure, Shock

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This document contains over 100 expertly curated practice questions and answers for the 2025 PCCN (Progressive Care Certified Nurse) Exam, covering essential knowledge areas for progressive and step-down unit nurses. Designed to align with AACN’s latest certification framework, this resource offers high-yield, scenario-based Q&A content that emphasizes both foundational and advanced clinical reasoning. The material spans critical systems and includes extensive practice on hemodynamic monitoring (CO, SV, CVP, PAOP, SVR, MAP), oxygenation and ventilation parameters, and early recognition of respiratory failure and shock. Students are guided through interpretation of ABGs, acid-base imbalances, and ventilator settings. The cardiovascular section reviews heart failure (HFrEF, HFpEF), ACS, valvular disorders, and cardiomyopathies, with real-case questions on BNP interpretation, troponin levels, and chest X-ray findings. Pharmacologic content includes the mechanisms, indications, and side effects of vasopressors, inotropes, diuretics, calcium channel blockers, ACE inhibitors, and antiarrhythmic agents. The document also includes practice on post-operative complications, fluid and electrolyte imbalances, and neuro and endocrine emergencies relevant to progressive care nursing. Ideal for candidates in: – PCCN exam preparation (AACN) – Progressive/Step-down Unit Nurses – Critical Care, Telemetry, and Intermediate Care Nurses – RN-to-BSN, BSN, and MSN students in cardiac or medical-surgical tracks – APRN students (FNP, AGACNP, CNS) focusing on inpatient care This comprehensive question bank serves as a powerful practice tool for exam readiness and clinical application in acute and progressive care environments. Keywords: PCCN 2025, progressive care nursing, hemodynamics, CVP, PAOP, SVR, MAP, ABG interpretation, respiratory failure, heart failure, ACS, BNP, troponin, preload, afterload, vasopressors, inotropes, diuretics, calcium channel blockers, ACE inhibitors, antiarrhythmics, ventilator settings, electrolyte imbalances, shock management, step-down unit

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Uploaded on
September 27, 2025
Number of pages
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Written in
2025/2026
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PCCN Practice Questions 2025/2026
Exam All Answers and Illustrations
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1. A 49-year-old male was recently admitted with an inferior wall

MI resulting from 100% occlusion of the right coronary artery

(RCA). The 12-Lead ECG reveals ST elevation in leads II, Ill, and avF.

You would expect to see reciprocal changes in which leads?

A. I, aVR

B. V, V2

C. V, VA


D I, aVL - 🧠 ANSWER ✔✔1. D. I, aVI. The RCA perfuses the inferior wall

and the mirror image or reciprocal change will be seen in the high latera

wall, which is reflected in leads I, and aVL, on the 12-Lead ECG. Leads V1

,and V2 correlate with the septal area, leads V3 and V4 correlate With the

anterior area of the heart. The aVR lead does not provide much diagnostic

value as all energy is depolarizing away from this lead.

You are summoned to the room of a 30-year-old female who is

experiencing sustained tonic-clonic convulsions while sitting in a chair. A

family member states: "She was just talking to us and suddenly she let out

a shriek and started flopping like a fish out of water." What is your initial

priority of care?

A. Call for help and safely guide the patient to the floor

B. Call for help and administer a prescribed antiepileptic

C. Call for help and administer a prescribed benzodiazepine


D. Call for help and monitor the course of the seizure - 🧠 ANSWER ✔✔A.

Call for help and safely guide the patient to the floor

Patient Safety is priority

A 46-year-old patient presents with pneumonia and sepsis.

He was treated with 4 days of antibiotics and IV fluids. He is increasingly

short of breath and is now on 100% FiO, via non-re-breather mask. You

obtain an ABG with the following results: pH 7.20 / PaCO, 68/ PaO, 102/

,HCO, 28. A chest x-ray reveals bilateral pulmonary infiltrates. The patient is

likely developing:

A. Worsening pneumonia

B. Acute Respiratory Distress Syndrome

C. Pulmonary embolus


D. Atelectasis - 🧠 ANSWER ✔✔B. Acute Respiratory Distress Syndrome


A 56-year-old male is admitted to the PCU with a hypertensive crisis. His

blood pressure is now 205/125 mm Hg and he is complaining of a

headache with nausea. He reports he ran out of blood pressure medication

three days ago, but also appears to be confused to the date and situation.

What is the most appropriate treatment approach?

A. Rapidly lower the systolic pressure to 100 mm Hg with IV

antihypertensive medication, then gradually reduce the diastolic pressure to

85 mm Hg with oral antihypertensive medications




B. Slowly lower the systolic pressure to 120 mm Hg with IV

antihypertensive medications, then switch to oral antihypertensive

medications for maintenance


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, C. Rapidly lower the diastolic pressure to 100 mm Hg with IV

antihypertensive medications, then continue to gradually reduce the

diastolic pressure to 85 mm Hg with oral antihypertensive medications




D. Slowly lower the diastolic pressure to 85 mm - 🧠 ANSWER ✔✔C.

Rapidly lower the diastolic pressure to 100 mm Hg with IV antihypertensive

medications, then continue to gradually reduce the diastolic pressure to 85

mm Hg with oral antihypertensive medication

5. Which of the following labs must be closely monitored when

administering Lisinopril to a patient with systolic heart failure?

A. Sodium

B. Phosphate

C. Magnesium


D Potassium - 🧠 ANSWER ✔✔D. Potassium


Patients taking angiotensin converting enzyme inhibitors may experience

hyperkalemia. ACE inhibitors block angiotensin II, which may lead to

decreased aldosterone. Aldosterone is responsible forexcreting potassium

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