NR565 Advanced Pharmacology Fundamentals Final
Exam ( Updated 2025-2026 ) 1 100 Complete Questions &
Answers (Solved) 100% Correct
Cytochrome P450 (CYP450) - CORRECT ANSWER-
xenobiotic-metabolizing enzymes necessary for the
production of cholesterol and steroids and the
detoxification of chemicals and drug metabolism.
Pharmacokinetics - CORRECT ANSWER-The process
by which drugs are absorbed, distributed within the
body, metabolized, and excreted.
,Pharmacodynamics - CORRECT ANSWER-The study
of what the drug does to the body
Factors Affecting Drug Absorption - CORRECT
ANSWER-Rate of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning
Factors Affecting Drug Distribution - CORRECT
ANSWER-Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
Xenobiotics - CORRECT ANSWER-substances that
are foreign to the body, usually synthetic chemical
compounds; medications are a common example
,Function of Cytochrome P450 (CYP450) - CORRECT
ANSWER-responsible for phase 1 metabolism in
which drugs are oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Drugs via P450 - CORRECT
ANSWER-Oxidation; Reduction; Hydrolysis
Three possible outcomes of phase 1 drug
metabolism. - CORRECT ANSWER--Drug becomes
completely inactive
-Drug becomes partially inactive but one or more
metabolites remain active
-Original drug is not pharmacologically active but
one metabolite remains active
, CYP450 Inducers - CORRECT ANSWER-Medications
that can increase the rate of another drug's
metabolism by elevating CYP450 enzyme activity via
increasing enzyme synthesis. decreasing the
concentration of the "parent drug"
CYP450 Inducer Medications - CORRECT ANSWER-
CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
CYP450 Inhibitors - CORRECT ANSWER-Medications
that inhibit the metabolic activity of one or more of
the CYP450 enzymes. Higher risk for toxicity;
Exam ( Updated 2025-2026 ) 1 100 Complete Questions &
Answers (Solved) 100% Correct
Cytochrome P450 (CYP450) - CORRECT ANSWER-
xenobiotic-metabolizing enzymes necessary for the
production of cholesterol and steroids and the
detoxification of chemicals and drug metabolism.
Pharmacokinetics - CORRECT ANSWER-The process
by which drugs are absorbed, distributed within the
body, metabolized, and excreted.
,Pharmacodynamics - CORRECT ANSWER-The study
of what the drug does to the body
Factors Affecting Drug Absorption - CORRECT
ANSWER-Rate of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning
Factors Affecting Drug Distribution - CORRECT
ANSWER-Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity
Xenobiotics - CORRECT ANSWER-substances that
are foreign to the body, usually synthetic chemical
compounds; medications are a common example
,Function of Cytochrome P450 (CYP450) - CORRECT
ANSWER-responsible for phase 1 metabolism in
which drugs are oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Drugs via P450 - CORRECT
ANSWER-Oxidation; Reduction; Hydrolysis
Three possible outcomes of phase 1 drug
metabolism. - CORRECT ANSWER--Drug becomes
completely inactive
-Drug becomes partially inactive but one or more
metabolites remain active
-Original drug is not pharmacologically active but
one metabolite remains active
, CYP450 Inducers - CORRECT ANSWER-Medications
that can increase the rate of another drug's
metabolism by elevating CYP450 enzyme activity via
increasing enzyme synthesis. decreasing the
concentration of the "parent drug"
CYP450 Inducer Medications - CORRECT ANSWER-
CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
CYP450 Inhibitors - CORRECT ANSWER-Medications
that inhibit the metabolic activity of one or more of
the CYP450 enzymes. Higher risk for toxicity;
