NSG554 ACTUAL EXAM 3| WITH COMPLETE QUESTIONS AND ANSWERS |
2025/206 LATEST UPDATED | 100 % RATED AND VERIFIED SOLUTIONS | GET
AN A+
Systematic Approach for Selection of Antimicrobials - (ANSWER)Confirm the presence of infection
Identify the pathogen
Select empiric therapy considering every infected site
Monitor therapeutic response
Hallmark for ID? - (ANSWER)FEVER
Controlled elevation of body temperature above normal range
Temp for fever - (ANSWER)> 37°C, 98.6°F
Consider APAP/NSAID mask
and drugs causing fever
How do differential WBC change with infection - (ANSWER)Total WBC over 10,000
Increased NEUtrophils
DECREAsed lymphocytes
,At least ___ of the 4 following signs and symptoms must be present for a patient to meet "SIRS" criteria -
(ANSWER)TWO
Temperature >38°C or <36°C
Heart rate >90 beats per minute
WBC >12,000 or <4,000 or >10% bands
Respiratory rate >20 breaths per minute
Confirming Sepsis - (ANSWER)Sepsis: life-threatening ***organ dysfunction*** caused by a dysregulated host
response to infection
Empiric therapy - (ANSWER)Best guess at causative organism and susceptibility
No culture and susceptibility results available
Directed at organisms that are known to cause the infection
Definitive therapy - (ANSWER)Choosing agent after culture and susceptibility reports available
Choose antimicrobial of choice for infection if it is susceptible and there are no contraindications
Selection of empiric therapy HOST factors - (ANSWER)Site of infection
**Drug allergies**
,**Age** -> ADR, organ f(x), etiology
Renal and hepatic function
Concomitant drug therapy
Concomitant disease states- CF (Pseudomonas, diabetics, infection)
Pregnancy
Selection of empiric therapy DRUG factors - (ANSWER)Tissue penetration
Pharmacokinetic and pharmacodynamics [PK-PD] considerations
T > MIC
Peak: MIC
AUC:MIC
Drug toxicity
Cost
Sanford Guide: Find ABX, antivirals, meds that do NOT require renal adjustment - (ANSWER)Table 17B
azithromycin
ceftriaaxone
chloramphenicol
ciprofloaxicin
clindamycin
, doxycycline
linezolid
minocycline
moxifloaxcin
nafcillin
ortiavancin
polymyxin B
Pyrimethamine
Rifaximi
Tedizolid
Tigecycline
T/F Selecting correct ABX therapy can improve patient outcomes - (ANSWER)Yes!!!! True
Pharmacodynamics ideal, concerntration dep. - (ANSWER)Cmax >>> MIC
want high peak compared to MIC
LARGE DOSES less frequently
concentration dep. abx _____ post antibiotic effect - (ANSWER)has good
2025/206 LATEST UPDATED | 100 % RATED AND VERIFIED SOLUTIONS | GET
AN A+
Systematic Approach for Selection of Antimicrobials - (ANSWER)Confirm the presence of infection
Identify the pathogen
Select empiric therapy considering every infected site
Monitor therapeutic response
Hallmark for ID? - (ANSWER)FEVER
Controlled elevation of body temperature above normal range
Temp for fever - (ANSWER)> 37°C, 98.6°F
Consider APAP/NSAID mask
and drugs causing fever
How do differential WBC change with infection - (ANSWER)Total WBC over 10,000
Increased NEUtrophils
DECREAsed lymphocytes
,At least ___ of the 4 following signs and symptoms must be present for a patient to meet "SIRS" criteria -
(ANSWER)TWO
Temperature >38°C or <36°C
Heart rate >90 beats per minute
WBC >12,000 or <4,000 or >10% bands
Respiratory rate >20 breaths per minute
Confirming Sepsis - (ANSWER)Sepsis: life-threatening ***organ dysfunction*** caused by a dysregulated host
response to infection
Empiric therapy - (ANSWER)Best guess at causative organism and susceptibility
No culture and susceptibility results available
Directed at organisms that are known to cause the infection
Definitive therapy - (ANSWER)Choosing agent after culture and susceptibility reports available
Choose antimicrobial of choice for infection if it is susceptible and there are no contraindications
Selection of empiric therapy HOST factors - (ANSWER)Site of infection
**Drug allergies**
,**Age** -> ADR, organ f(x), etiology
Renal and hepatic function
Concomitant drug therapy
Concomitant disease states- CF (Pseudomonas, diabetics, infection)
Pregnancy
Selection of empiric therapy DRUG factors - (ANSWER)Tissue penetration
Pharmacokinetic and pharmacodynamics [PK-PD] considerations
T > MIC
Peak: MIC
AUC:MIC
Drug toxicity
Cost
Sanford Guide: Find ABX, antivirals, meds that do NOT require renal adjustment - (ANSWER)Table 17B
azithromycin
ceftriaaxone
chloramphenicol
ciprofloaxicin
clindamycin
, doxycycline
linezolid
minocycline
moxifloaxcin
nafcillin
ortiavancin
polymyxin B
Pyrimethamine
Rifaximi
Tedizolid
Tigecycline
T/F Selecting correct ABX therapy can improve patient outcomes - (ANSWER)Yes!!!! True
Pharmacodynamics ideal, concerntration dep. - (ANSWER)Cmax >>> MIC
want high peak compared to MIC
LARGE DOSES less frequently
concentration dep. abx _____ post antibiotic effect - (ANSWER)has good
