NR 546 PSYCHOPHARMACOLOGY FINAL EXAM
REVIEW 2025/26 QUESTIONS AND ANSWER
CHAPTERS 7-11 | GRADED A
Rick is a 52-year-old truck driver who consumes large quantities of caffeine in order
to stay awake. Caffeine likely promotes wakefulness and opposes homeostatic drive
through its actions as an antagonist of:
Adenosine
Presynaptic reuptake transporters are a major method of inactivation for which of the
following?
Serotonin and GABA
Patrick is a 22-year-old male who recently experienced a psychotic-like episode after
trying MDMA (""ecstasy"") while at a party. A key binding site for hallucinogens is the:
Serotonin 2A receptor
Patricia is a 17-year-old high school student with ADHD. She often has difficulty paying
attention in class and completing assignments. Problems with selective attention
associated with ADHD are hypothetically regulated by the:
Anterior cingulate cortex
,PET imaging of a 69-year-old patient with mild cognitive impairment (MCI) has shown
some beta amyloid brain deposition. Which apolipoprotein E (APOE) genotype would
predict a faster progression from MCI to Alzheimer's dementia?
APOE4
Neuroimaging data show that neuronal activity in the amygdala of depressed patients
is:
A. Overactive to induced sadness
B. Underreactive to induced happiness
Marty is a 71-year-old patient in with a family history of Alzheimer's disease. He has
been participating in an Alzheimer's disease research study for the past 5 years. In the
study, he has been categorized as ""prodromal"" based on biomarker results and
neuropsychiatric testing. Which of the following biomarker results are indicative of
Alzheimer's disease?
Elevated CSF tau and decreased CSF beta amyloid
Marie is a young mother who is worried that her 3-year-old son may have ADHD
because he often loses focus when he is performing simple tasks. Inattentive
symptoms become noticeable at what age?
5-6 years old
, Marcus is a 19-year-old patient who was diagnosed with ADHD when he was 9. He has
recently graduated high school and is scheduled to start his first semester at college
next month. As individuals with ADHD progress into adulthood, they generally
experience a decline in:
B. Impulsive symptoms. C. Hyperactive symptoms
The alpha 2 delta sub-unit of voltage-sensitive calcium channels is believed to help
regulate opening and closing of the voltage-sensitive calcium channel. True or False
TRUE
Which of the following statements regarding mood symptoms is true?
Symptoms related to increased negative affect are hypothetically linked to
serotonergic (and noradrenergic) dysfunction
Which of the following is true?
Both positive and negative allosteric modulations are possible only in the presence of
a neurotransmitter
Which of the following is true about depression and reproductive hormones?
Depression is linked to estrogen levels in women across their life cycles
REVIEW 2025/26 QUESTIONS AND ANSWER
CHAPTERS 7-11 | GRADED A
Rick is a 52-year-old truck driver who consumes large quantities of caffeine in order
to stay awake. Caffeine likely promotes wakefulness and opposes homeostatic drive
through its actions as an antagonist of:
Adenosine
Presynaptic reuptake transporters are a major method of inactivation for which of the
following?
Serotonin and GABA
Patrick is a 22-year-old male who recently experienced a psychotic-like episode after
trying MDMA (""ecstasy"") while at a party. A key binding site for hallucinogens is the:
Serotonin 2A receptor
Patricia is a 17-year-old high school student with ADHD. She often has difficulty paying
attention in class and completing assignments. Problems with selective attention
associated with ADHD are hypothetically regulated by the:
Anterior cingulate cortex
,PET imaging of a 69-year-old patient with mild cognitive impairment (MCI) has shown
some beta amyloid brain deposition. Which apolipoprotein E (APOE) genotype would
predict a faster progression from MCI to Alzheimer's dementia?
APOE4
Neuroimaging data show that neuronal activity in the amygdala of depressed patients
is:
A. Overactive to induced sadness
B. Underreactive to induced happiness
Marty is a 71-year-old patient in with a family history of Alzheimer's disease. He has
been participating in an Alzheimer's disease research study for the past 5 years. In the
study, he has been categorized as ""prodromal"" based on biomarker results and
neuropsychiatric testing. Which of the following biomarker results are indicative of
Alzheimer's disease?
Elevated CSF tau and decreased CSF beta amyloid
Marie is a young mother who is worried that her 3-year-old son may have ADHD
because he often loses focus when he is performing simple tasks. Inattentive
symptoms become noticeable at what age?
5-6 years old
, Marcus is a 19-year-old patient who was diagnosed with ADHD when he was 9. He has
recently graduated high school and is scheduled to start his first semester at college
next month. As individuals with ADHD progress into adulthood, they generally
experience a decline in:
B. Impulsive symptoms. C. Hyperactive symptoms
The alpha 2 delta sub-unit of voltage-sensitive calcium channels is believed to help
regulate opening and closing of the voltage-sensitive calcium channel. True or False
TRUE
Which of the following statements regarding mood symptoms is true?
Symptoms related to increased negative affect are hypothetically linked to
serotonergic (and noradrenergic) dysfunction
Which of the following is true?
Both positive and negative allosteric modulations are possible only in the presence of
a neurotransmitter
Which of the following is true about depression and reproductive hormones?
Depression is linked to estrogen levels in women across their life cycles
