HEMATOLOGY MLS ASCP BOC FINAL MIDTERM EXAM
WITH WELL DETAILED QUESTION & ANSWERS
PERFECTLY A+ GRADED NEW 2025 UPDATE
Hemoglobin types CORRECT ANSWER>>>>-HbA (alpha2, beta2) is most prevalent*
-HbA2 (alpha2, delta2)
-HbF (alpha2, gamma2)
- HbH beta4 - severe alpha thalassemia
- Bart - gamma4- severe alpha thalassemia
Hemoglobin electrophoresis CORRECT ANSWER>>>>routine: pH 8.6
- HbH and HbBart travel fastest
- HbA2 and F travel together
- HbS, HbD, HbG migrate together
Abnormal: citrate at pH of 6.2
- distinguish HbF, S, and C
, Hemoglobin oxygen dissociation curve CORRECT ANSWER>>>>Shift to the left- O2
NOT released to tissue adequately
Shift to the right- O2 released to tissue more easily
Amount of Hgb in sickle cell trait CORRECT ANSWER>>>>HbA = 50-70%
HbS = 20-40 %
G6PD deficiency CORRECT ANSWER>>>>X linked
African American and Mediterranean
oxidation of hemoglobin forms Heinz bodies (supravital stain)
Pyruvate Kinase Deficiency CORRECT ANSWER>>>>Autosomal recessive
Limits ATP production
Burr cells
Paroxysmal Cold Hemoglobinuria CORRECT ANSWER>>>>Biphasic IgG from anti-P and
Donath-Landsteiner antibody
Secondary to viral infection, measles, mumps, chickenpox, mononucleosis
Hereditary spherocytosis CORRECT ANSWER>>>>Autosomal dominant causes RBC
membrane defects, usually ankyrin or spectrin
Increased MCHC
Increased osmotic fragility
Increased LD and bilirubin
WITH WELL DETAILED QUESTION & ANSWERS
PERFECTLY A+ GRADED NEW 2025 UPDATE
Hemoglobin types CORRECT ANSWER>>>>-HbA (alpha2, beta2) is most prevalent*
-HbA2 (alpha2, delta2)
-HbF (alpha2, gamma2)
- HbH beta4 - severe alpha thalassemia
- Bart - gamma4- severe alpha thalassemia
Hemoglobin electrophoresis CORRECT ANSWER>>>>routine: pH 8.6
- HbH and HbBart travel fastest
- HbA2 and F travel together
- HbS, HbD, HbG migrate together
Abnormal: citrate at pH of 6.2
- distinguish HbF, S, and C
, Hemoglobin oxygen dissociation curve CORRECT ANSWER>>>>Shift to the left- O2
NOT released to tissue adequately
Shift to the right- O2 released to tissue more easily
Amount of Hgb in sickle cell trait CORRECT ANSWER>>>>HbA = 50-70%
HbS = 20-40 %
G6PD deficiency CORRECT ANSWER>>>>X linked
African American and Mediterranean
oxidation of hemoglobin forms Heinz bodies (supravital stain)
Pyruvate Kinase Deficiency CORRECT ANSWER>>>>Autosomal recessive
Limits ATP production
Burr cells
Paroxysmal Cold Hemoglobinuria CORRECT ANSWER>>>>Biphasic IgG from anti-P and
Donath-Landsteiner antibody
Secondary to viral infection, measles, mumps, chickenpox, mononucleosis
Hereditary spherocytosis CORRECT ANSWER>>>>Autosomal dominant causes RBC
membrane defects, usually ankyrin or spectrin
Increased MCHC
Increased osmotic fragility
Increased LD and bilirubin
