APMLE BIOCHEMISTRY RAPID REVIEW ASSESSMENT EXAM
WITH IN-DEPTH QUESTIONS & MODEL ANSWERS (2025
NEWEST UPDATE)
Rate determining Step of glycolysis CORRECT ANSWER>>>>Phosphofructokinase-1
(PFK-1)
Rate determining Step of gluconeogenesis CORRECT ANSWER>>>>Fructose-1,6-
bisphosphatase
Rate determining Step of TCA (Krebs) CORRECT ANSWER>>>>Isocitrate
Dehydrogenase
Rate determining Step of glycogenesis CORRECT ANSWER>>>>glycogen synthase
Rate determining Step of of glycogenolysis CORRECT ANSWER>>>>glycogen
phosphorylase
Rate determining Step of HMP Shunt CORRECT ANSWER>>>>G6PD (glucose-6-
phosphate dehydrogenase)
, Rate determining Step of De Novo Pyrimidine Synthesis CORRECT
ANSWER>>>>Carbamoyl Phosphate Synthase II
Rate determining Step of De Novo PURINE Synthesis CORRECT
ANSWER>>>>Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase
Rate determining Step of Urea Cycle CORRECT ANSWER>>>>Carbamoyl phosphate
synthetase I
Rate determining Step of Fatty Acid Synthesis CORRECT ANSWER>>>>Acetyl CoA
carboxylase
Rate determining Step of fatty acid oxidation CORRECT ANSWER>>>>Carnitine
acyltransferase I
Rate determining Step of ketogenesis CORRECT ANSWER>>>>HMG-CoA synthase
Rate determining Step of cholesterol synthesis CORRECT ANSWER>>>>HMG-CoA
reductase
Irreversible Steps of the Krebs cycle CORRECT ANSWER>>>>Citrate Synthase
IsoCitrate Dehydrogenase
Alpha-KG dehydrogenase
Name the essential amino acids CORRECT ANSWER>>>>PVT TIM HaLL
WITH IN-DEPTH QUESTIONS & MODEL ANSWERS (2025
NEWEST UPDATE)
Rate determining Step of glycolysis CORRECT ANSWER>>>>Phosphofructokinase-1
(PFK-1)
Rate determining Step of gluconeogenesis CORRECT ANSWER>>>>Fructose-1,6-
bisphosphatase
Rate determining Step of TCA (Krebs) CORRECT ANSWER>>>>Isocitrate
Dehydrogenase
Rate determining Step of glycogenesis CORRECT ANSWER>>>>glycogen synthase
Rate determining Step of of glycogenolysis CORRECT ANSWER>>>>glycogen
phosphorylase
Rate determining Step of HMP Shunt CORRECT ANSWER>>>>G6PD (glucose-6-
phosphate dehydrogenase)
, Rate determining Step of De Novo Pyrimidine Synthesis CORRECT
ANSWER>>>>Carbamoyl Phosphate Synthase II
Rate determining Step of De Novo PURINE Synthesis CORRECT
ANSWER>>>>Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase
Rate determining Step of Urea Cycle CORRECT ANSWER>>>>Carbamoyl phosphate
synthetase I
Rate determining Step of Fatty Acid Synthesis CORRECT ANSWER>>>>Acetyl CoA
carboxylase
Rate determining Step of fatty acid oxidation CORRECT ANSWER>>>>Carnitine
acyltransferase I
Rate determining Step of ketogenesis CORRECT ANSWER>>>>HMG-CoA synthase
Rate determining Step of cholesterol synthesis CORRECT ANSWER>>>>HMG-CoA
reductase
Irreversible Steps of the Krebs cycle CORRECT ANSWER>>>>Citrate Synthase
IsoCitrate Dehydrogenase
Alpha-KG dehydrogenase
Name the essential amino acids CORRECT ANSWER>>>>PVT TIM HaLL
