TEST BANK pm
Cellular and Molecular Immunology
pm pm pm
Abul Abbas, Andrew Lichtman, and Shiv Pillai
pm pm pm pm pm pm
10th Edition
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,Table of Contents
pm pm
Chapter 01 Properties and Overview of Immune Responses
pm pm pm pm pm pm pm 1
Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
pm pm pm pm pm pm pm 6
Chapter 04 Innate Immunity
pm pm pm 10
Chapter 05 Antibodies and Antigens
pm pm pm pm 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
pm pm pm pm pm pm pm pm pm pm pm
Histocompatibility Complex Molecules
pm pm 20
Chapter 07 Immune Receptors and Signal Transduction
pm pm pm pm pm pm 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
pm pm pm pm pm pm pm pm 30
Chapter 09 Activation of T Lymphocytes
pm pm pm pm pm 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
pm pm pm pm pm pm pm pm pm 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
pm pm pm pm pm pm pm pm pm 42
Chapter 12 B Cell Activation and Antibody Production
pm pm pm pm pm pm pm 46
Chapter 13 Effector Mechanisms of Humoral Immunity
pm pm pm pm pm pm 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
pm pm pm pm pm pm pm pm pm pm pm 56
Chapter 15 Immunologic Tolerance and Autoimmunity
pm pm pm pm pm 62
Chapter 16 Immunity to Microbes
pm pm pm pm 67
Chapter 17 Transplantation Immunology
pm pm pm 72
Chapter 18 Tumor Immunology
pm pm pm 77
Chapter 19 Hypersensitivity Disorders
pm pm pm 81
Chapter 20 Allergy
pm pm 86
Chapter 21 Primary and Acquired Immunodeficiencies
pm pm pm pm pm 89
,Chapter 01: Properties and Overview of Immune Responses
pm pm pm pm pm pm pm
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
pm pm pm pm pm pm pm pm pm
MULTIPLE CHOICE pm
1. The principal function of the immune system is:
pm pm pm pm pm pm pm
a. Defense against cancer pm pm
b. Repair of injured tissues pm pm pm
c. Defense against microbial infections pm pm pm
d. Prevention of inflammatory diseases pm pm pm
e. Protection against environmental toxins pm pm pm
ANS: C p m
The immune system has evolved in the setting of selective pressures imposed by microbia
pm pm pm pm pm pm pm pm pm pm pm pm pm
l infections. Although immune responses to cancer may occur, the concept that “immuno
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surveillance” against cancer is a principal function of the immune system is controversial
pm pm pm pm pm pm pm pm pm pm pm pm
. Repair of injured tissues may be a secondary consequence of the immune responses and
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
inflammation. Although the immune system has regulatory features that are needed to pr
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event excessive inflammation, prevention of inflammatory diseases is not a primary funct
pm pm pm pm pm pm pm pm pm pm pm
ion. The immune system can protect against microbial toxins, but it generally does not off
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
er protection against toxins of nonbiologic origin.
pm pm pm pm pm pm
2. Which of the following infectious diseases was prevented by the first successf
pm pm pm pm pm pm pm pm pm pm pm
ul vaccination?
pm
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p m
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
pm pm pm pm pm pm pm pm pm pm pm pm
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
, smallpox was reported to be eradicated worldwide by a vaccination program. Effective
pm pm pm pm pm pm pm pm pm pm pm pm pm
vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c
pm pm pm pm pm pm pm pm pm pm pm pm pm
entury and are widely used. There is no effective vaccine against Mycobacterium tubercu
pm pm pm pm pm pm pm pm pm pm pm pm
losis.
3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens
pm pm pm pm pm pm
b. Self-nonself discrimination pm
c. Recognition of microbial structures by both cell-associated and soluble receptors
pm pm pm pm pm pm pm pm pm
d. Protection against viral infections pm pm pm
e. Responses that have the same kinetics and magnitude on repeated exposure to th
pm pm pm pm pm pm pm pm pm pm pm pm
e same microbe pm pm
ANS: p m A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
cytes, which are the central cellular components of the adaptive immune system. Both th
pm pm pm pm pm pm pm pm pm pm pm pm pm
e innate and the adaptive immune systems use cell-
pm pm pm pm pm pm pm pm
associated and soluble receptors to recognize microbes, display some degree of self-
pm pm pm pm pm pm pm pm pm pm pm
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
pm pm pm pm pm pm pm pm pm pm pm pm
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
pm pm pm pm pm pm pm pm pm pm pm pm pm
s the manifestation of memory.
pm pm pm pm
4. Antibodies and T lymphocytes are the respective mediators of which two types o
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f immunity?
pm
a. Innate and adaptive pm pm
b. Passive and active pm pm
c. Specific and nonspecific pm pm
d. Humoral and cell-mediated pm pm
e. Adult and neonatal pm pm
ANS: D p m
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
pm pm pm pm pm pm pm pm pm pm pm pm
s produce antibodies, which are the recognition and effector molecules of humoral immun
pm pm pm pm pm pm pm pm pm pm pm pm
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
pm pm pm pm pm pm pm pm pm pm pm pm
ellular pathogens in cell-
pm pm pm
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
pm pm pm pm pm pm pm pm pm pm pm pm pm
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
pm pm pm pm pm pm pm pm pm pm pm pm pm
d.
5. The two major functional classes of effector T lymphocytes are:
pm pm pm pm pm pm pm pm pm
a. Helper T lymphocytes and cytotoxic T lymphocytes
pm pm pm pm pm pm
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
pm pm pm pm
c. Memory T cells and effector T cells pm pm pm pm pm pm
d. Helper cells and antigen-presenting cells pm pm pm pm
e. Cytotoxic T lymphocytes and target cells pm pm pm pm pm
ANS: A p m
T cells can be classified into effector subsets that perform different effector functions. Mos
pm pm pm pm pm pm pm pm pm pm pm pm pm
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
pm pm pm pm pm pm pm pm pm pm pm pm
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
pm pm pm pm pm pm pm pm pm pm pm pm
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. pm pm pm pm pm pm pm pm pm pm pm pm pm pm
6. Which of the following cell types is required for all adaptive humoral immune responses?
pm pm pm pm pm pm pm pm pm pm pm pm pm
a. Natural killer cells pm pm
b. Dendritic cells pm
c. Cytolytic T lymphocytes pm pm
d. B lymphocytes pm
e. Helper T lymphocytes pm pm
ANS: D p m
Humoral immune responses are antibody-
pm pm pm pm
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
pm pm pm pm pm pm pm pm pm pm pm pm pm
er cell type.
pm pm
Cellular and Molecular Immunology
pm pm pm
Abul Abbas, Andrew Lichtman, and Shiv Pillai
pm pm pm pm pm pm
10th Edition
pm
,Table of Contents
pm pm
Chapter 01 Properties and Overview of Immune Responses
pm pm pm pm pm pm pm 1
Chapter 02 Cells and Tissues of the Immune System
pm pm pm pm pm pm pm pm 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
pm pm pm pm pm pm pm 6
Chapter 04 Innate Immunity
pm pm pm 10
Chapter 05 Antibodies and Antigens
pm pm pm pm 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
pm pm pm pm pm pm pm pm pm pm pm
Histocompatibility Complex Molecules
pm pm 20
Chapter 07 Immune Receptors and Signal Transduction
pm pm pm pm pm pm 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
pm pm pm pm pm pm pm pm 30
Chapter 09 Activation of T Lymphocytes
pm pm pm pm pm 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
pm pm pm pm pm pm pm pm pm 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
pm pm pm pm pm pm pm pm pm 42
Chapter 12 B Cell Activation and Antibody Production
pm pm pm pm pm pm pm 46
Chapter 13 Effector Mechanisms of Humoral Immunity
pm pm pm pm pm pm 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
pm pm pm pm pm pm pm pm pm pm pm 56
Chapter 15 Immunologic Tolerance and Autoimmunity
pm pm pm pm pm 62
Chapter 16 Immunity to Microbes
pm pm pm pm 67
Chapter 17 Transplantation Immunology
pm pm pm 72
Chapter 18 Tumor Immunology
pm pm pm 77
Chapter 19 Hypersensitivity Disorders
pm pm pm 81
Chapter 20 Allergy
pm pm 86
Chapter 21 Primary and Acquired Immunodeficiencies
pm pm pm pm pm 89
,Chapter 01: Properties and Overview of Immune Responses
pm pm pm pm pm pm pm
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
pm pm pm pm pm pm pm pm pm
MULTIPLE CHOICE pm
1. The principal function of the immune system is:
pm pm pm pm pm pm pm
a. Defense against cancer pm pm
b. Repair of injured tissues pm pm pm
c. Defense against microbial infections pm pm pm
d. Prevention of inflammatory diseases pm pm pm
e. Protection against environmental toxins pm pm pm
ANS: C p m
The immune system has evolved in the setting of selective pressures imposed by microbia
pm pm pm pm pm pm pm pm pm pm pm pm pm
l infections. Although immune responses to cancer may occur, the concept that “immuno
pm pm pm pm pm pm pm pm pm pm pm pm
surveillance” against cancer is a principal function of the immune system is controversial
pm pm pm pm pm pm pm pm pm pm pm pm
. Repair of injured tissues may be a secondary consequence of the immune responses and
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
inflammation. Although the immune system has regulatory features that are needed to pr
pm pm pm pm pm pm pm pm pm pm pm pm pm
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
pm pm pm pm pm pm pm pm pm pm pm
ion. The immune system can protect against microbial toxins, but it generally does not off
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
er protection against toxins of nonbiologic origin.
pm pm pm pm pm pm
2. Which of the following infectious diseases was prevented by the first successf
pm pm pm pm pm pm pm pm pm pm pm
ul vaccination?
pm
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p m
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
pm pm pm pm pm pm pm pm pm pm pm pm
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
, smallpox was reported to be eradicated worldwide by a vaccination program. Effective
pm pm pm pm pm pm pm pm pm pm pm pm pm
vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c
pm pm pm pm pm pm pm pm pm pm pm pm pm
entury and are widely used. There is no effective vaccine against Mycobacterium tubercu
pm pm pm pm pm pm pm pm pm pm pm pm
losis.
3. Which of the following is a unique property of the adaptive immune system?
pm pm pm pm pm pm pm pm pm pm pm pm
a. Highly diverse repertoire of specificities for antigens
pm pm pm pm pm pm
b. Self-nonself discrimination pm
c. Recognition of microbial structures by both cell-associated and soluble receptors
pm pm pm pm pm pm pm pm pm
d. Protection against viral infections pm pm pm
e. Responses that have the same kinetics and magnitude on repeated exposure to th
pm pm pm pm pm pm pm pm pm pm pm pm
e same microbe pm pm
ANS: p m A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
cytes, which are the central cellular components of the adaptive immune system. Both th
pm pm pm pm pm pm pm pm pm pm pm pm pm
e innate and the adaptive immune systems use cell-
pm pm pm pm pm pm pm pm
associated and soluble receptors to recognize microbes, display some degree of self-
pm pm pm pm pm pm pm pm pm pm pm
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
pm pm pm pm pm pm pm pm pm pm pm pm
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
pm pm pm pm pm pm pm pm pm pm pm pm pm
s the manifestation of memory.
pm pm pm pm
4. Antibodies and T lymphocytes are the respective mediators of which two types o
pm pm pm pm pm pm pm pm pm pm pm pm
f immunity?
pm
a. Innate and adaptive pm pm
b. Passive and active pm pm
c. Specific and nonspecific pm pm
d. Humoral and cell-mediated pm pm
e. Adult and neonatal pm pm
ANS: D p m
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
pm pm pm pm pm pm pm pm pm pm pm pm
s produce antibodies, which are the recognition and effector molecules of humoral immun
pm pm pm pm pm pm pm pm pm pm pm pm
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
pm pm pm pm pm pm pm pm pm pm pm pm
ellular pathogens in cell-
pm pm pm
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
pm pm pm pm pm pm pm pm pm pm pm pm pm
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
pm pm pm pm pm pm pm pm pm pm pm pm pm
d.
5. The two major functional classes of effector T lymphocytes are:
pm pm pm pm pm pm pm pm pm
a. Helper T lymphocytes and cytotoxic T lymphocytes
pm pm pm pm pm pm
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
pm pm pm pm
c. Memory T cells and effector T cells pm pm pm pm pm pm
d. Helper cells and antigen-presenting cells pm pm pm pm
e. Cytotoxic T lymphocytes and target cells pm pm pm pm pm
ANS: A p m
T cells can be classified into effector subsets that perform different effector functions. Mos
pm pm pm pm pm pm pm pm pm pm pm pm pm
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
pm pm pm pm pm pm pm pm pm pm pm pm
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
pm pm pm pm pm pm pm pm pm pm pm pm
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. pm pm pm pm pm pm pm pm pm pm pm pm pm pm
6. Which of the following cell types is required for all adaptive humoral immune responses?
pm pm pm pm pm pm pm pm pm pm pm pm pm
a. Natural killer cells pm pm
b. Dendritic cells pm
c. Cytolytic T lymphocytes pm pm
d. B lymphocytes pm
e. Helper T lymphocytes pm pm
ANS: D p m
Humoral immune responses are antibody-
pm pm pm pm
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
pm pm pm pm pm pm pm pm pm pm pm pm pm
er cell type.
pm pm
