MB (ASCP) 2021 - Translocations, Diseases, Pharma&Polymerases EXAM 2026 QUESTIONS AND ANSWERS

MB (ASCP) 2021 - Translocations,
Diseases, Pharma&Polymerases EXAM
2026 QUESTIONS AND ANSWERS

Chronic Myeloid Leukemia (CML) - Correct Answer -t(9;22)

BCR-ABL translocation

Ewing sarcoma - Correct Answer -t(11;22)

EWS-FLI1

Acute Lymphocytic Leukemia (ALL) - Correct Answer -t(9;22)

BCR-ABL

p190 protein

Follicular Lymphoma - Correct Answer -t(14;18)

BCL2 translocation

Mantle Cell Lymphoma - Correct Answer -t(11;14) bcl-1 translocation

CCND1-IgH


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,Burkitt Lymphoma - Correct Answer -t(8;14)

MYC gene translocation

Rhabdomyosarcoma (alveolar); Cancer/solid tumor - Correct Answer -t(2;13) or

t(1;13)

PAX3-FKHR and PAX7-FKHR

"ARMS" translocation

AML (Acute Myeloid Leukemia) - Correct Answer -t(8;21)

inv(16)

t(15;17)




RUNX1, RUNX1T1

APL (Acute Promyelocytic Leukemia)




also AML-3 - Correct Answer -t(15;17)




note: A *P* L = *P* ML-RARA (remember the P)


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, Marginal Zone Lymphoma - Correct Answer -t(11;18)

Prostatic adenocarcinoma - Correct Answer -t(7;21) or t(17;21)

Sezary Syndrome (Cutaneous T-Cell Lymphomia) - Correct Answer -TCR gene

rearrangements

Synovial sarcoma - Correct Answer -t(X;18)

SYT-SSX

Breast Cancer - Correct Answer -HER2/ERBB2

- BRCA1 mutation: 185delAG and 5832insC

- BRCA2 mutation: 6174delT

Lung Cancer (NSCLC) - Correct Answer -EGFR mutation = L858R

also Thr790Met

Colorectal Carcinoma (CRC) - Correct Answer -BRAF V600E mutation

also PIK3CA mutation (E542 and E545 in exon 9)

Melanoma (skin cancer) - Correct Answer -BRAF V600E mutation (c.1799T>A)

Target amplification methods - Correct Answer -PCR + qPCR

RT-PCR


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