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CHS Practice Exam (Certified
Histocompatibility Specialist) Questions
and Correct Answers/ Latest Update /
Already Graded
Which of the following is not a secondary lymphoid organ?
a. Spleen
b. Thymus
c. Lymph nodes
d. Liver
e. Tonsils
Ans: Thymus
Primary lymphatic organs are where lymphocytes are formed
and mature.
stem cells to divide and mature into B- and T- cells:
There are two primary lymphatic organs: the red bone marrow
and the thymus gland.
Which of the following is not a component of the reticuloendothelial
cell system?
a. Microglial cells
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b. Kupffer cells
c. Langerhans cells
d. Neutrophils
e. Monocytes
Ans: Neutrophils
Macrophages = tissue
Monocytes = blood
Kupffer cells = liver
Microgial cells = nervous system
Langerhans = skin
Not = endothelial cells, fibroblasts, and most leukocytes
Opsonization is a term to describe what?
a. Lysis of bacteria
b. Coating of bacteria
c. Ingestion of bacteria
d. Killing of bacteria
e. Phagocytosis
Ans: Coating of bacteria
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Antibody opsonization is the process by which a pathogen is
marked for ingestion and eliminated by a phagocyte.
Which of the following does not describe a role of antibodies in host
defense?
a. They serve as a bridge between bacteria and phagocytes
b. They lyse bacteria
c. They enhance complement binding to the bacterial cell wall
d. They prevent viruses from infecting cells
e. They bind pathogens in mucus secretions
Ans: They lyse bacteria
MHC Class I and II molecules differ in all of the following except
a. Types of T cells they stimulate
b. Types of cells they are expressed on
c. Which chromosome they are located on
d. Types of antigens they present
e. Whether or not they have foreign peptides in the antigen-binding
groove
Ans: Which chromosome they are located on
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The primary role of the proteasome in antigen presentation is to
a. Prevent premature folding of MHC class I molecules
b. Process cytoplasmic proteins
c. Degrade recycled MHC molecules
d. Bind HLA-DM in the endosome
e. Chaperone peptides to the cell surface
Ans: Process cytoplasmic proteins
The main function of the proteasome is to degrade unneeded or
damaged proteins by proteolysis, a chemical reaction that
breaks peptide bonds.
Peptides that bind to MHC class I molecules differ from peptides that
bind to MHC class II molecules in all
except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC molecule
d. They interact with different subsets of T cells
All rights reserved © 2025/ 2026 |
CHS Practice Exam (Certified
Histocompatibility Specialist) Questions
and Correct Answers/ Latest Update /
Already Graded
Which of the following is not a secondary lymphoid organ?
a. Spleen
b. Thymus
c. Lymph nodes
d. Liver
e. Tonsils
Ans: Thymus
Primary lymphatic organs are where lymphocytes are formed
and mature.
stem cells to divide and mature into B- and T- cells:
There are two primary lymphatic organs: the red bone marrow
and the thymus gland.
Which of the following is not a component of the reticuloendothelial
cell system?
a. Microglial cells
All rights reserved © 2025/ 2026 |
, Page |2
b. Kupffer cells
c. Langerhans cells
d. Neutrophils
e. Monocytes
Ans: Neutrophils
Macrophages = tissue
Monocytes = blood
Kupffer cells = liver
Microgial cells = nervous system
Langerhans = skin
Not = endothelial cells, fibroblasts, and most leukocytes
Opsonization is a term to describe what?
a. Lysis of bacteria
b. Coating of bacteria
c. Ingestion of bacteria
d. Killing of bacteria
e. Phagocytosis
Ans: Coating of bacteria
All rights reserved © 2025/ 2026 |
, Page |3
Antibody opsonization is the process by which a pathogen is
marked for ingestion and eliminated by a phagocyte.
Which of the following does not describe a role of antibodies in host
defense?
a. They serve as a bridge between bacteria and phagocytes
b. They lyse bacteria
c. They enhance complement binding to the bacterial cell wall
d. They prevent viruses from infecting cells
e. They bind pathogens in mucus secretions
Ans: They lyse bacteria
MHC Class I and II molecules differ in all of the following except
a. Types of T cells they stimulate
b. Types of cells they are expressed on
c. Which chromosome they are located on
d. Types of antigens they present
e. Whether or not they have foreign peptides in the antigen-binding
groove
Ans: Which chromosome they are located on
All rights reserved © 2025/ 2026 |
, Page |4
The primary role of the proteasome in antigen presentation is to
a. Prevent premature folding of MHC class I molecules
b. Process cytoplasmic proteins
c. Degrade recycled MHC molecules
d. Bind HLA-DM in the endosome
e. Chaperone peptides to the cell surface
Ans: Process cytoplasmic proteins
The main function of the proteasome is to degrade unneeded or
damaged proteins by proteolysis, a chemical reaction that
breaks peptide bonds.
Peptides that bind to MHC class I molecules differ from peptides that
bind to MHC class II molecules in all
except which of the following ways?
a. They are shorter
b. They were processed by different proteases
c. They anchor in the middle instead of the end of the MHC molecule
d. They interact with different subsets of T cells
All rights reserved © 2025/ 2026 |
