TEST BANK
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance:10Pathophysiology:10The10Biologic10Basis10for10Disease10in10Adults10and10Children10(8th10Edi
tion)10TEST10BANK
CONTENTS:
Chapter1001:10Cellular10Biology
Chapter1002:10Altered10Cellular10and10Tissue10Biology:10Environmental10Agents
Chapter1003:10The10Cellular10Environment:10Fluids10and10Electrolytes,10Acids10and10Bases
Chapter1004:10Genes10and10Genetic10Diseases
Chapter1005:10Genes,10Environment-Lifestyle,10and10 Common10Diseases
Chapter1006:10Epigenetics10and10Disease
Chapter1007:10Innate10Immunity:10Inflammation10and10Wound10Healing
Chapter1008:10Adaptive10Immunity
Chapter1009:10Alterations10in10Immunity10and10Inflammation
Chapter1010:10Infection
Chapter1011:10Stress10and10Disease
Chapter1012:10Cancer10Biology
Chapter1013:10Cancer10Epidemiology
Chapter1014:10Cancer10in10Children
Chapter1015:10Structure10and10Function10of10the10Neurologic10System
Chapter1016:10Pain,10Temperature10Regulation,10Sleep,10and10Sensory10Function
Chapter1017:10Alterations10in10Cognitive10Systems,10Cerebral10Hemodynamics,10and10Motor10Function
Chapter1018:10Disorders10of10the10Central10and10Peripheral10Nervous10Systems10and10the10Neuromuscular10Juncti
on
Chapter1019:10Neurobiology10of10Schizophrenia,10Mood10Disorders,10and10Anxiety10Disorders
Chapter1020:10Alterations10of10Neurologic10Function10in10Children
Chapter1021:10Mechanisms10of10Hormonal10Regulation
Chapter1022:10Alterations10of10Hormonal10Regulation
Chapter1023:10Obesity10and10Disorders10of10Nutrition
Chapter1024:10Structure10and10Function10of10the10Reproductive10Systems
Chapter1025:10Alterations10of10the10Female10Reproductive10System
Chapter1026:10Alterations10of10the10Male10Reproductive10System
Chapter1027:10Sexually10Transmitted10Infections
Chapter1028:10Structure10and10Function10of10the10Hematologic10System
Chapter1029:10Alterations10of10Erythrocytes,10Platelets,10and10Hemostatic10Function
Chapter1030:10Alterations10of10Leukocyte10and10Lymphoid10Function
Chapter1031:10Alterations10of10Hematologic10Function10in10Children
Chapter1032:10Structure10and10Function10of10the10Cardiovascular10and10Lymphatic10Systems
Chapter1033:10Alterations10of10Cardiovascular10Function
Chapter1034:10Alterations10of10Cardiovascular10Function10in10Children
Chapter1035:10Structure10and10Function10of10the10Pulmonary10System
Chapter1036:10Alterations10of10Pulmonary10Function
Chapter1037:10Alterations10of10Pulmonary10Function10in10Children
Chapter1038:10Structure10and10Function10of10the10Renal10and10Urologic10Systems
Chapter1039:10Alterations10of10Renal10and10Urinary10Tract10Function
Chapter1040:10Alterations10of10Renal10and10Urinary10Tract10Function10in10Children
Chapter1041:10Structure10and10Function10of10the10Digestive10System
Chapter1042:10Alterations10of10Digestive10Function
Chapter1043:10Alterations10of10Digestive10Function10in10Children
Chapter1044:10Structure10and10Function10of10the10Musculoskeletal10System
Chapter1045:10Alterations10of10Musculoskeletal10 Function
Chapter1046:10Alterations10of10Musculoskeletal10Function10in10Children
Chapter1047:10Structure,10Function,10and10Disorders10of10the10Integument
Chapter1048:10Alterations10of10the10Integument10in10Children
Chapter1049:10Shock,10Multiple10Organ10Dysfunction10Syndrome,10and10Burns10in10Adults
Chapter1050:10Shock,10Multiple10Organ10Dysfunction10Syndrome,10and10Burns10in10Children
, (8th1 0 Children
McCance:1 0 Pathophysiology:1 0 The1 0 Biologic1 0 Basis1 0 for1 0 Disease1 0 in1 0 Adults1 0 and
Edition)1 0 TEST1
0B
Part101:10CENTRAL10CONCEPTS10OF10PATHOPHYSIOLOGY:10CELLS10AND10TISS
UES10Unit10I:10THE10CELL
CHAPTER1001:10CELLULAR10BIOLOGY
MULTIPLE10CHOICE
1. Which10statement10best10describes10the10cellular10function10of10metabolic10absorption?
a. Cells10can10produce10proteins.
b. Cells10can10secrete10digestive10enzy
mes.
c. Cells10can10take10in10and10use10nutri
ents.
d. Cells10can10synthesize10fats.
ANS:10 C
In10metabolic10absorption,10all10cells10take10in10and10use10nutrients10and10other10substances10fro
m10their10surroundings.10The10remaining10options10are10not10inclusive10in10their10descriptions10of
10cellular10metabolic10absorption.
PTS:1 0 1 0 1 DIF: Cognitive10Level:10Remembering
2. Where1 0 is1 0 most1 0 of1 0 a1 0 cell’s1 0 genetic1 0 information,1 0 including1 0 RNA1 0 and1 0 DNA,1 0 contained
?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:1 0 C
The1 0 nucleus1 0 contains1 0 the1 0 nucleolus,1 0 a1 0 small1 0 dense1 0 structure1 0 composed1 0 largely1
0 of1 0 RNA,1 0 mos10t1 0 of1 0 the1 0 cellular1 0 DNA,1 0 and1 0 the1 0 DNA-
binding1 0 proteins,1 0 such1 0 as1 0 the1 0 histones,1 0 which1 0 regulate1 0 its1 0 activity.1 0 The1 0 mitoc
hondria1 0 are1 0 res10ponsible1 0 for1 0 cellular1 0 respiration1 0 and1 0 energy1 0 production.
Ribosomes’10chief10function1 0 is1 0 to10provide1 0 sites1 0 for10cellular10protein1 0 synthesis.1 0 Lysos
omes1 0 functi10on1 0 as1 0 the1 0 intracellular1 0 digestive1 0 system.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
3. Which1 0 component1 0 of1 0 the1 0 cell1 0 produces1 0 hydrogen1 0 peroxide1 0 (H2O2)1 0 by10using1
0 oxygen1 0 to1 0 re10move1 0 hydrogen1 0 atoms1 0 from1 0 specific1 0 substrates1 0 in1 0 an1 0 oxida
tive1 0 reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:1 0 B
, (8th1 0 Children
McCance:1 0 Pathophysiology:1 0 The1 0 Biologic1 0 Basis1 0 for1 0 Disease1 0 in1 0 Adults1 0 and
Edition)1 0 TEST1
0B
Peroxisomes1 0 are1 0 so1 0 named1 0 because1 0 they1 0 usually1 0 contain1 0 enzymes1 0 that1 0 use1 0 o
xygen1 0 to1 0 remo10ve1 0 hydrogen1 0 atoms1 0 from1 0 specific1 0 substrates1 0 in1 0 an1 0 oxidative1 0 r
eaction1 0 that1 0 produces1 0 H2O2,1 0 wh10ich1 0 is1 0 a1 0 powerful1 0 oxidant1 0 and1 0 potentially1 0 de
structive1 0 if1 0 it1 0 accumulates1 0 or1 0 escapes1 0 from1 0 pero10xisomes.
Ribosomes1 0 are1 0 RNA-
protein1 0 complexes1 0 (nucleoproteins)1 0 that1 0 are1 0 synthesized1 0 in1 0 the1 0 nucleolus1 0 and1 0 s
ecreted1 0 into1 0 t10he1 0 cytoplasm1 0 through1 0 pores1 0 in1 0 the1 0 nuclear1 0 envelope1 0 called1 0 nu
clear1 0 pore1 0 complexes.1 0 Lysoso10mes1 0 are1 0 saclike1 0 structures1 0 that1 0 originate1 0 from1 0 t
he1 0 Golgi1 0 complex1 0 and1 0 contain1 0 more1 0 than1 0 4010digestive1 0 enzymes1 0 called1 0 hydrol
ases,1 0 which1 0 catalyze1 0 bonds1 0 in1 0 proteins,1 0 lipids,1 0 nucleic1 0 acids
,1 0 and1 0 carbohydrates.1 0 An1 0 endosome1 0 is1 0 a1 0 vesical1 0 that1 0 has1 0 been1 0 pinched1 0 off1
0 from1 0 the1 0 cellular10membrane.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
4. Which1 0 cell1 0 component1 0 is1 0 capable1 0 of1 0 cellular1 0 autodigestion1 0 when1 0 it1 0 is1 0 released1 0 durin
g1 0 cell1 0 injury?
a. Ribosome
b. Golgi1 0 complex
c. Smooth10 endoplasmic10 reticu
lu10m
d. Lysosomes
ANS:1 0 D
The1 0 lysosomal1 0 membrane1 0 acts1 0 as1 0 a1 0 protective1 0 shield1 0 between1 0 the1 0 powerful1 0 d
igestive1 0 enzym10es10within10the10lysosome10and10the10cytoplasm,10preventing10their10leakage1
0into10the10cytoplasmic10m1 0 atrix.1 0 Disruption1 0 of1 0 the1 0 membrane1 0 by1 0 various1 0 treatme
nts1 0 or1 0 cellular1 0 injury1 0 leads1 0 to1 0 a1 0 releas10e10of10the10lysosomal10enzymes,10which10ca
n10then10react10with10their10specific10substrates,10causing10ce1 0 llular1 0 self-
digestion.1 0 The1 0 chief1 0 function1 0 of1 0 a1 0 ribosome1 0 is1 0 to1 0 provide1 0 sites1 0 for1 0 cellular1 0 protein1
0 synthesis
.1 0 The1 0 Golgi1 0 complex1 0 is1 0 a1 0 network1 0 of1 0 flattened,1 0 smooth1 0 vesicles1 0 and1 0 membra
nes1 0 often1 0 locate10d1 0 near1 0 the1 0 cell1 0 nucleus.1 0 The1 0 smooth1 0 endoplasmic1 0 reticulum1
0 is1 0 involved1 0 in1 0 steroid1 0 hormone10production1 0 and1 0 removing1 0 toxic1 0 substances1 0 fro
m1 0 the1 0 cell.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
5. Which1 0 cAMP-mediated1 0 response1 0 is1 0 related1 0 to1 0 antidiuretic1 0 hormone?
a. Increased1 0 heart1 0 rate1 0 and1 0 force10of1 0 c
ontracti10on
b. Secretion1 0 of1 0 cortisol
c. Increased1 0 retention1 0 of1 0 water
d. Breakdown1 0 of1 0 fat
ANS:1 0 C
Antidiuretic1 0 hormone1 0 leads1 0 to1 0 increased1 0 retention1 0 of1 0 water1 0 in1 0 the1 0 body.1 0 Epin
ephrine1 0 causes10increases1 0 in1 0 heart1 0 rate1 0 and1 0 force1 0 of1 0 contraction.1 0 Increased1 0 cor
tisol1 0 secretion1 0 is1 0 due1 0 to1 0 ACT
H.1 0 Breakdown1 0 of1 0 fat1 0 is1 0 due1 0 to1 0 glucagon.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
6. During1 0 which1 0 phase1 0 of1 0 the1 0 cell1 0 cycle1 0 is1 0 DNA1 0 synthesized?
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance:10Pathophysiology:10The10Biologic10Basis10for10Disease10in10Adults10and10Children10(8th10Edi
tion)10TEST10BANK
CONTENTS:
Chapter1001:10Cellular10Biology
Chapter1002:10Altered10Cellular10and10Tissue10Biology:10Environmental10Agents
Chapter1003:10The10Cellular10Environment:10Fluids10and10Electrolytes,10Acids10and10Bases
Chapter1004:10Genes10and10Genetic10Diseases
Chapter1005:10Genes,10Environment-Lifestyle,10and10 Common10Diseases
Chapter1006:10Epigenetics10and10Disease
Chapter1007:10Innate10Immunity:10Inflammation10and10Wound10Healing
Chapter1008:10Adaptive10Immunity
Chapter1009:10Alterations10in10Immunity10and10Inflammation
Chapter1010:10Infection
Chapter1011:10Stress10and10Disease
Chapter1012:10Cancer10Biology
Chapter1013:10Cancer10Epidemiology
Chapter1014:10Cancer10in10Children
Chapter1015:10Structure10and10Function10of10the10Neurologic10System
Chapter1016:10Pain,10Temperature10Regulation,10Sleep,10and10Sensory10Function
Chapter1017:10Alterations10in10Cognitive10Systems,10Cerebral10Hemodynamics,10and10Motor10Function
Chapter1018:10Disorders10of10the10Central10and10Peripheral10Nervous10Systems10and10the10Neuromuscular10Juncti
on
Chapter1019:10Neurobiology10of10Schizophrenia,10Mood10Disorders,10and10Anxiety10Disorders
Chapter1020:10Alterations10of10Neurologic10Function10in10Children
Chapter1021:10Mechanisms10of10Hormonal10Regulation
Chapter1022:10Alterations10of10Hormonal10Regulation
Chapter1023:10Obesity10and10Disorders10of10Nutrition
Chapter1024:10Structure10and10Function10of10the10Reproductive10Systems
Chapter1025:10Alterations10of10the10Female10Reproductive10System
Chapter1026:10Alterations10of10the10Male10Reproductive10System
Chapter1027:10Sexually10Transmitted10Infections
Chapter1028:10Structure10and10Function10of10the10Hematologic10System
Chapter1029:10Alterations10of10Erythrocytes,10Platelets,10and10Hemostatic10Function
Chapter1030:10Alterations10of10Leukocyte10and10Lymphoid10Function
Chapter1031:10Alterations10of10Hematologic10Function10in10Children
Chapter1032:10Structure10and10Function10of10the10Cardiovascular10and10Lymphatic10Systems
Chapter1033:10Alterations10of10Cardiovascular10Function
Chapter1034:10Alterations10of10Cardiovascular10Function10in10Children
Chapter1035:10Structure10and10Function10of10the10Pulmonary10System
Chapter1036:10Alterations10of10Pulmonary10Function
Chapter1037:10Alterations10of10Pulmonary10Function10in10Children
Chapter1038:10Structure10and10Function10of10the10Renal10and10Urologic10Systems
Chapter1039:10Alterations10of10Renal10and10Urinary10Tract10Function
Chapter1040:10Alterations10of10Renal10and10Urinary10Tract10Function10in10Children
Chapter1041:10Structure10and10Function10of10the10Digestive10System
Chapter1042:10Alterations10of10Digestive10Function
Chapter1043:10Alterations10of10Digestive10Function10in10Children
Chapter1044:10Structure10and10Function10of10the10Musculoskeletal10System
Chapter1045:10Alterations10of10Musculoskeletal10 Function
Chapter1046:10Alterations10of10Musculoskeletal10Function10in10Children
Chapter1047:10Structure,10Function,10and10Disorders10of10the10Integument
Chapter1048:10Alterations10of10the10Integument10in10Children
Chapter1049:10Shock,10Multiple10Organ10Dysfunction10Syndrome,10and10Burns10in10Adults
Chapter1050:10Shock,10Multiple10Organ10Dysfunction10Syndrome,10and10Burns10in10Children
, (8th1 0 Children
McCance:1 0 Pathophysiology:1 0 The1 0 Biologic1 0 Basis1 0 for1 0 Disease1 0 in1 0 Adults1 0 and
Edition)1 0 TEST1
0B
Part101:10CENTRAL10CONCEPTS10OF10PATHOPHYSIOLOGY:10CELLS10AND10TISS
UES10Unit10I:10THE10CELL
CHAPTER1001:10CELLULAR10BIOLOGY
MULTIPLE10CHOICE
1. Which10statement10best10describes10the10cellular10function10of10metabolic10absorption?
a. Cells10can10produce10proteins.
b. Cells10can10secrete10digestive10enzy
mes.
c. Cells10can10take10in10and10use10nutri
ents.
d. Cells10can10synthesize10fats.
ANS:10 C
In10metabolic10absorption,10all10cells10take10in10and10use10nutrients10and10other10substances10fro
m10their10surroundings.10The10remaining10options10are10not10inclusive10in10their10descriptions10of
10cellular10metabolic10absorption.
PTS:1 0 1 0 1 DIF: Cognitive10Level:10Remembering
2. Where1 0 is1 0 most1 0 of1 0 a1 0 cell’s1 0 genetic1 0 information,1 0 including1 0 RNA1 0 and1 0 DNA,1 0 contained
?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:1 0 C
The1 0 nucleus1 0 contains1 0 the1 0 nucleolus,1 0 a1 0 small1 0 dense1 0 structure1 0 composed1 0 largely1
0 of1 0 RNA,1 0 mos10t1 0 of1 0 the1 0 cellular1 0 DNA,1 0 and1 0 the1 0 DNA-
binding1 0 proteins,1 0 such1 0 as1 0 the1 0 histones,1 0 which1 0 regulate1 0 its1 0 activity.1 0 The1 0 mitoc
hondria1 0 are1 0 res10ponsible1 0 for1 0 cellular1 0 respiration1 0 and1 0 energy1 0 production.
Ribosomes’10chief10function1 0 is1 0 to10provide1 0 sites1 0 for10cellular10protein1 0 synthesis.1 0 Lysos
omes1 0 functi10on1 0 as1 0 the1 0 intracellular1 0 digestive1 0 system.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
3. Which1 0 component1 0 of1 0 the1 0 cell1 0 produces1 0 hydrogen1 0 peroxide1 0 (H2O2)1 0 by10using1
0 oxygen1 0 to1 0 re10move1 0 hydrogen1 0 atoms1 0 from1 0 specific1 0 substrates1 0 in1 0 an1 0 oxida
tive1 0 reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:1 0 B
, (8th1 0 Children
McCance:1 0 Pathophysiology:1 0 The1 0 Biologic1 0 Basis1 0 for1 0 Disease1 0 in1 0 Adults1 0 and
Edition)1 0 TEST1
0B
Peroxisomes1 0 are1 0 so1 0 named1 0 because1 0 they1 0 usually1 0 contain1 0 enzymes1 0 that1 0 use1 0 o
xygen1 0 to1 0 remo10ve1 0 hydrogen1 0 atoms1 0 from1 0 specific1 0 substrates1 0 in1 0 an1 0 oxidative1 0 r
eaction1 0 that1 0 produces1 0 H2O2,1 0 wh10ich1 0 is1 0 a1 0 powerful1 0 oxidant1 0 and1 0 potentially1 0 de
structive1 0 if1 0 it1 0 accumulates1 0 or1 0 escapes1 0 from1 0 pero10xisomes.
Ribosomes1 0 are1 0 RNA-
protein1 0 complexes1 0 (nucleoproteins)1 0 that1 0 are1 0 synthesized1 0 in1 0 the1 0 nucleolus1 0 and1 0 s
ecreted1 0 into1 0 t10he1 0 cytoplasm1 0 through1 0 pores1 0 in1 0 the1 0 nuclear1 0 envelope1 0 called1 0 nu
clear1 0 pore1 0 complexes.1 0 Lysoso10mes1 0 are1 0 saclike1 0 structures1 0 that1 0 originate1 0 from1 0 t
he1 0 Golgi1 0 complex1 0 and1 0 contain1 0 more1 0 than1 0 4010digestive1 0 enzymes1 0 called1 0 hydrol
ases,1 0 which1 0 catalyze1 0 bonds1 0 in1 0 proteins,1 0 lipids,1 0 nucleic1 0 acids
,1 0 and1 0 carbohydrates.1 0 An1 0 endosome1 0 is1 0 a1 0 vesical1 0 that1 0 has1 0 been1 0 pinched1 0 off1
0 from1 0 the1 0 cellular10membrane.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
4. Which1 0 cell1 0 component1 0 is1 0 capable1 0 of1 0 cellular1 0 autodigestion1 0 when1 0 it1 0 is1 0 released1 0 durin
g1 0 cell1 0 injury?
a. Ribosome
b. Golgi1 0 complex
c. Smooth10 endoplasmic10 reticu
lu10m
d. Lysosomes
ANS:1 0 D
The1 0 lysosomal1 0 membrane1 0 acts1 0 as1 0 a1 0 protective1 0 shield1 0 between1 0 the1 0 powerful1 0 d
igestive1 0 enzym10es10within10the10lysosome10and10the10cytoplasm,10preventing10their10leakage1
0into10the10cytoplasmic10m1 0 atrix.1 0 Disruption1 0 of1 0 the1 0 membrane1 0 by1 0 various1 0 treatme
nts1 0 or1 0 cellular1 0 injury1 0 leads1 0 to1 0 a1 0 releas10e10of10the10lysosomal10enzymes,10which10ca
n10then10react10with10their10specific10substrates,10causing10ce1 0 llular1 0 self-
digestion.1 0 The1 0 chief1 0 function1 0 of1 0 a1 0 ribosome1 0 is1 0 to1 0 provide1 0 sites1 0 for1 0 cellular1 0 protein1
0 synthesis
.1 0 The1 0 Golgi1 0 complex1 0 is1 0 a1 0 network1 0 of1 0 flattened,1 0 smooth1 0 vesicles1 0 and1 0 membra
nes1 0 often1 0 locate10d1 0 near1 0 the1 0 cell1 0 nucleus.1 0 The1 0 smooth1 0 endoplasmic1 0 reticulum1
0 is1 0 involved1 0 in1 0 steroid1 0 hormone10production1 0 and1 0 removing1 0 toxic1 0 substances1 0 fro
m1 0 the1 0 cell.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
5. Which1 0 cAMP-mediated1 0 response1 0 is1 0 related1 0 to1 0 antidiuretic1 0 hormone?
a. Increased1 0 heart1 0 rate1 0 and1 0 force10of1 0 c
ontracti10on
b. Secretion1 0 of1 0 cortisol
c. Increased1 0 retention1 0 of1 0 water
d. Breakdown1 0 of1 0 fat
ANS:1 0 C
Antidiuretic1 0 hormone1 0 leads1 0 to1 0 increased1 0 retention1 0 of1 0 water1 0 in1 0 the1 0 body.1 0 Epin
ephrine1 0 causes10increases1 0 in1 0 heart1 0 rate1 0 and1 0 force1 0 of1 0 contraction.1 0 Increased1 0 cor
tisol1 0 secretion1 0 is1 0 due1 0 to1 0 ACT
H.1 0 Breakdown1 0 of1 0 fat1 0 is1 0 due1 0 to1 0 glucagon.
PTS: 1 DIF: Cognitive1 0 Level:1 0 Remembering
6. During1 0 which1 0 phase1 0 of1 0 the1 0 cell1 0 cycle1 0 is1 0 DNA1 0 synthesized?
