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Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of I mmune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
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Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular a nd Molecular Immunology, 10th E dition
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MULTIPLE CHOICE mf
1. The principal f unction of the i mmune system is:
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a. Defense against cancer mf mf
b. Repair of injured t issues mf mf mf
c. Defense against microbial infections mf mf mf
d. Prevention of inflammatory d iseases mf mf mf
e. Protection against environmental t oxins mf mf mf
ANS: C m f
The immune system has evolved in the setting of selective pressures imposed by microbial
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infections. Although immune responses to cancer may occur, the concept that “immunosur
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veillance” against cancer is a principal function of the immune system is controversial. Re
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pair of injured tissues may be a secondary consequence of the immune responses and infla
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mmation. Although the immune system has regulatory features that are needed to prevent
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excessive inflammation, prevention of inflammatory diseases is not a primary f unction. Th
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e immune system can protect against microbial toxins, but it generally does not offer protec
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tion against toxins of nonbiologic origin.
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2. Which of t he following infectious diseases was prevented by t he f irst successful
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vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C m f
In 1798, Edward Jenner reported the first intentional successful vaccination, which was ag
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ainst smallpox in a boy, using material from the cowpox pustules of a m ilkmaid. In 1980, s
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mallpox was reported to be eradicated worldwide by a vaccination program. Effective vac
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cines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th centur
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y and are widely used. There is no effective vaccine against Mycobacterium tuberculosis.
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3. Which of t he following is a unique property of the adaptive immune system?
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a. Highly d iverse repertoire of specificities f or antigensmf mf mf mf mf mf
b. Self-nonself discrimination mf
c. Recognition of microbial structures by both cell-associated and soluble receptors mf mf mf mf mf mf mf mf mf
d. Protection against viral infections mf mf mf
e. Responses that have t he same kinetics and magnitude on repeated exposure to the
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same microbe mf mf
ANS: m f A
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphoc
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ytes, which are the central cellular components of the adaptive immune system. Both the i
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nnate and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same micr
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obe, the adaptive immune response becomes more rapid and of greater magnitude; this is t
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he manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
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a. Innate and adaptive mf mf
b. Passive and active mf mf
c. Specific and nonspecific mf mf
d. Humoral and cell-mediated mf mf
e. Adult and neonatal mf mf
ANS: D m f
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
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produce antibodies, which are the recognition and effector molecules of humoral immune r
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esponses to extracellular pathogens. T cells recognize and promote eradication of intracellul
mf mf mf mf mf mf mf mf mf mf mf
ar pathogens in cell-
mf mf mf
mediated immunity. Passive and active immunity both can be mediated by either B or T lym
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phocytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocy
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tes participate in adult adaptive immunity but are still developing in the neonatal period.
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5. The t wo major f unctional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes mf mf mf mf mf mf
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes mf mf mf mf
c. Memory T cells and effector T cells mf mf mf mf mf mf
d. Helper cells and antigen-presenting cells mf mf mf mf
e. Cytotoxic T lymphocytes and t arget cells mf mf mf mf mf
ANS: A m f
T cells can be classified into effector subsets that perform different effector functions. Most
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effector T cells are either helper T lymphocytes, which enhance the responses of other im
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mune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, w
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hich directly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually a re not T c ells. Memory T cells are not effector T cells. mf mf mf mf mf mf mf mf mf mf mf mf mf mf
6. Which of t he f ollowing cell types i s required for all adaptive humoral immune responses?
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a. Natural killer cells mf mf
b. Dendritic cells mf
c. Cytolytic T lymphocytes mf mf
d. B lymphocytes mf
e. Helper T lymphocytes mf mf
ANS: D m f
Humoral immune r esponses are antibody- mf mf mf mf
mediated immune responses, and all antibodies are made by B lymphocytes and no other
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cell type.
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Cellular and Molecular Immunology
mf mf mf
Abul Abbas, Andrew Lichtman, and Shiv Pillai
mf mf mf mf mf mf
10th Edition
mf
,Table of Contents
mf mf
Chapter 01 Properties and Overview of I mmune Responses
mf mf mf mf mf mf mf 1
Chapter 02 Cells and Tissues of the Immune System
mf mf mf mf mf mf mf mf 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
mf mf mf mf mf mf mf 6
Chapter 04 Innate Immunity
mf mf mf 10
Chapter 05 Antibodies and Antigens
mf mf mf mf 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
mf mf 20
Chapter 07 Immune Receptors and Signal Transduction
mf mf mf mf mf mf 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
mf mf mf mf mf mf mf mf 30
Chapter 09 Activation of T Lymphocytes
mf mf mf mf mf 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
mf mf mf mf mf mf mf mf mf 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
mf mf mf mf mf mf mf mf mf 42
Chapter 12 B Cell Activation and Antibody Production
mf mf mf mf mf mf mf 46
Chapter 13 Effector Mechanisms of Humoral Immunity
mf mf mf mf mf mf 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
mf mf mf mf mf mf mf mf mf mf mf 56
Chapter 15 Immunologic Tolerance and Autoimmunity
mf mf mf mf mf 62
Chapter 16 Immunity to Microbes
mf mf mf mf 67
Chapter 17 Transplantation Immunology
mf mf mf 72
Chapter 18 Tumor Immunology
mf mf mf 77
Chapter 19 Hypersensitivity Disorders
mf mf mf 81
Chapter 20 Allergy
mf mf 86
Chapter 21 Primary and Acquired Immunodeficiencies
mf mf mf mf mf 89
,Chapter 01: Properties and Overview of Immune Responses
mf mf mf mf mf mf mf
Abbas, Lichtman, and Pillai: Cellular a nd Molecular Immunology, 10th E dition
mf mf mf mf mf mf mf mf mf
MULTIPLE CHOICE mf
1. The principal f unction of the i mmune system is:
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a. Defense against cancer mf mf
b. Repair of injured t issues mf mf mf
c. Defense against microbial infections mf mf mf
d. Prevention of inflammatory d iseases mf mf mf
e. Protection against environmental t oxins mf mf mf
ANS: C m f
The immune system has evolved in the setting of selective pressures imposed by microbial
mf mf mf mf mf mf mf mf mf mf mf mf mf mf
infections. Although immune responses to cancer may occur, the concept that “immunosur
mf mf mf mf mf mf mf mf mf mf mf
veillance” against cancer is a principal function of the immune system is controversial. Re
mf mf mf mf mf mf mf mf mf mf mf mf mf
pair of injured tissues may be a secondary consequence of the immune responses and infla
mf mf mf mf mf mf mf mf mf mf mf mf mf mf
mmation. Although the immune system has regulatory features that are needed to prevent
mf mf mf mf mf mf mf mf mf mf mf mf mf
excessive inflammation, prevention of inflammatory diseases is not a primary f unction. Th
mf mf mf mf mf mf mf mf mf mf mf
e immune system can protect against microbial toxins, but it generally does not offer protec
mf mf mf mf mf mf mf mf mf mf mf mf mf mf
tion against toxins of nonbiologic origin.
mf mf mf mf mf
2. Which of t he following infectious diseases was prevented by t he f irst successful
mf mf mf mf mf mf mf mf mf mf mf
vaccination?
mf
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C m f
In 1798, Edward Jenner reported the first intentional successful vaccination, which was ag
mf mf mf mf mf mf mf mf mf mf mf mf
ainst smallpox in a boy, using material from the cowpox pustules of a m ilkmaid. In 1980, s
mf mf mf mf mf mf mf mf mf mf mf mf mf mf mf mf
mallpox was reported to be eradicated worldwide by a vaccination program. Effective vac
mf mf mf mf mf mf mf mf mf mf mf mf
cines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th centur
mf mf mf mf mf mf mf mf mf mf mf mf mf
y and are widely used. There is no effective vaccine against Mycobacterium tuberculosis.
mf mf mf mf mf mf mf mf mf mf mf mf
3. Which of t he following is a unique property of the adaptive immune system?
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a. Highly d iverse repertoire of specificities f or antigensmf mf mf mf mf mf
b. Self-nonself discrimination mf
c. Recognition of microbial structures by both cell-associated and soluble receptors mf mf mf mf mf mf mf mf mf
d. Protection against viral infections mf mf mf
e. Responses that have t he same kinetics and magnitude on repeated exposure to the
mf mf mf mf mf mf mf mf mf mf mf mf
same microbe mf mf
ANS: m f A
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphoc
mf mf mf mf mf mf mf mf mf mf mf mf mf mf
ytes, which are the central cellular components of the adaptive immune system. Both the i
mf mf mf mf mf mf mf mf mf mf mf mf mf mf
nnate and the adaptive immune systems use cell-
mf mf mf mf mf mf mf
associated and soluble receptors to recognize microbes, display some degree of self-
mf mf mf mf mf mf mf mf mf mf mf
nonself discrimination, and protect against viruses. On repeated exposure to the same micr
mf mf mf mf mf mf mf mf mf mf mf mf
obe, the adaptive immune response becomes more rapid and of greater magnitude; this is t
mf mf mf mf mf mf mf mf mf mf mf mf mf mf
he manifestation of memory.
mf mf mf
4. Antibodies and T lymphocytes are the respective mediators of which two types of
mf mf mf mf mf mf mf mf mf mf mf mf
immunity?
mf
a. Innate and adaptive mf mf
b. Passive and active mf mf
c. Specific and nonspecific mf mf
d. Humoral and cell-mediated mf mf
e. Adult and neonatal mf mf
ANS: D m f
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
mf mf mf mf mf mf mf mf mf mf mf mf mf
produce antibodies, which are the recognition and effector molecules of humoral immune r
mf mf mf mf mf mf mf mf mf mf mf mf
esponses to extracellular pathogens. T cells recognize and promote eradication of intracellul
mf mf mf mf mf mf mf mf mf mf mf
ar pathogens in cell-
mf mf mf
mediated immunity. Passive and active immunity both can be mediated by either B or T lym
mf mf mf mf mf mf mf mf mf mf mf mf mf mf mf
phocytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocy
mf mf mf mf mf mf mf mf mf mf mf mf mf
tes participate in adult adaptive immunity but are still developing in the neonatal period.
mf mf mf mf mf mf mf mf mf mf mf mf mf
5. The t wo major f unctional classes of effector T lymphocytes are:
mf mf mf mf mf mf mf mf mf
a. Helper T lymphocytes and cytotoxic T lymphocytes mf mf mf mf mf mf
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes mf mf mf mf
c. Memory T cells and effector T cells mf mf mf mf mf mf
d. Helper cells and antigen-presenting cells mf mf mf mf
e. Cytotoxic T lymphocytes and t arget cells mf mf mf mf mf
ANS: A m f
T cells can be classified into effector subsets that perform different effector functions. Most
mf mf mf mf mf mf mf mf mf mf mf mf mf m
effector T cells are either helper T lymphocytes, which enhance the responses of other im
f mf mf mf mf mf mf mf mf mf mf mf mf mf mf
mune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, w
mf mf mf mf mf mf mf mf mf mf mf mf mf
hich directly kill infected cells. Natural killer cells are not T lymphocytes.
mf mf mf mf mf mf mf mf mf mf mf
Antigen-presenting cells usually a re not T c ells. Memory T cells are not effector T cells. mf mf mf mf mf mf mf mf mf mf mf mf mf mf
6. Which of t he f ollowing cell types i s required for all adaptive humoral immune responses?
mf mf mf mf mf mf mf mf mf mf mf mf mf
a. Natural killer cells mf mf
b. Dendritic cells mf
c. Cytolytic T lymphocytes mf mf
d. B lymphocytes mf
e. Helper T lymphocytes mf mf
ANS: D m f
Humoral immune r esponses are antibody- mf mf mf mf
mediated immune responses, and all antibodies are made by B lymphocytes and no other
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cell type.
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