TEST BANK
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance:44Pathophysiology:44The44Biologic44Basis44for44Disease44in44Adults44and44Children44(8th44Edi
tion)44TEST44BANK
CONTENTS:
Chapter4401:44Cellular44Biology
Chapter4402:44Altered44Cellular44and44Tissue44Biology:44Environmental44Agents
Chapter4403:44The44Cellular44Environment:44Fluids44and44Electrolytes,44Acids44and44Bases
Chapter4404:44Genes44and44Genetic44Diseases
Chapter4405:44Genes,44Environment-Lifestyle,44and44 Common44Diseases
Chapter4406:44Epigenetics44and44Disease
Chapter4407:44Innate44Immunity:44Inflammation44and44Wound44Healing
Chapter4408:44Adaptive44Immunity
Chapter4409:44Alterations44in44Immunity44and44Inflammation
Chapter4410:44Infection
Chapter4411:44Stress44and44Disease
Chapter4412:44Cancer44Biology
Chapter4413:44Cancer44Epidemiology
Chapter4414:44Cancer44in44Children
Chapter4415:44Structure44and44Function44of44the44Neurologic44System
Chapter4416:44Pain,44Temperature44Regulation,44Sleep,44and44Sensory44Function
Chapter4417:44Alterations44in44Cognitive44Systems,44Cerebral44Hemodynamics,44and44Motor44Function
Chapter4418:44Disorders44of44the44Central44and44Peripheral44Nervous44Systems44and44the44Neuromuscular44Juncti
on
Chapter4419:44Neurobiology44of44Schizophrenia,44Mood44Disorders,44and44Anxiety44Disorders
Chapter4420:44Alterations44of44Neurologic44Function44in44Children
Chapter4421:44Mechanisms44of44Hormonal44Regulation
Chapter4422:44Alterations44of44Hormonal44Regulation
Chapter4423:44Obesity44and44Disorders44of44Nutrition
Chapter4424:44Structure44and44Function44of44the44Reproductive44Systems
Chapter4425:44Alterations44of44the44Female44Reproductive44System
Chapter4426:44Alterations44of44the44Male44Reproductive44System
Chapter4427:44Sexually44Transmitted44Infections
Chapter4428:44Structure44and44Function44of44the44Hematologic44System
Chapter4429:44Alterations44of44Erythrocytes,44Platelets,44and44Hemostatic44Function
Chapter4430:44Alterations44of44Leukocyte44and44Lymphoid44Function
Chapter4431:44Alterations44of44Hematologic44Function44in44Children
Chapter4432:44Structure44and44Function44of44the44Cardiovascular44and44Lymphatic44Systems
Chapter4433:44Alterations44of44Cardiovascular44Function
Chapter4434:44Alterations44of44Cardiovascular44Function44in44Children
Chapter4435:44Structure44and44Function44of44the44Pulmonary44System
Chapter4436:44Alterations44of44Pulmonary44Function
Chapter4437:44Alterations44of44Pulmonary44Function44in44Children
Chapter4438:44Structure44and44Function44of44the44Renal44and44Urologic44Systems
Chapter4439:44Alterations44of44Renal44and44Urinary44Tract44Function
Chapter4440:44Alterations44of44Renal44and44Urinary44Tract44Function44in44Children
Chapter4441:44Structure44and44Function44of44the44Digestive44System
Chapter4442:44Alterations44of44Digestive44Function
Chapter4443:44Alterations44of44Digestive44Function44in44Children
Chapter4444:44Structure44and44Function44of44the44Musculoskeletal44System
Chapter4445:44Alterations44of44Musculoskeletal44 Function
Chapter4446:44Alterations44of44Musculoskeletal44Function44in44Children
Chapter4447:44Structure,44Function,44and44Disorders44of44the44Integument
Chapter4448:44Alterations44of44the44Integument44in44Children
Chapter4449:44Shock,44Multiple44Organ44Dysfunction44Syndrome,44and44Burns44in44Adults
Chapter4450:44Shock,44Multiple44Organ44Dysfunction44Syndrome,44and44Burns44in44Children
, (8th4 4 Children
McCance:4 4 Pathophysiology:4 4 The4 4 Biologic4 4 Basis4 4 for4 4 Disease4 4 in4 4 Adults4 4 and
Edition)4 4 TEST4
4B
Part441:44CENTRAL44CONCEPTS44OF44PATHOPHYSIOLOGY:44CELLS44AND44TISS
UES44Unit44I:44THE44CELL
CHAPTER4401:44CELLULAR44BIOLOGY
MULTIPLE44CHOICE
1. Which44statement44best44describes44the44cellular44function44of44metabolic44absorption?
a. Cells44can44produce44proteins.
b. Cells44can44secrete44digestive44enzy
mes.
c. Cells44can44take44in44and44use44nutri
ents.
d. Cells44can44synthesize44fats.
ANS:44 C
In44metabolic44absorption,44all44cells44take44in44and44use44nutrients44and44other44substances44fro
m44their44surroundings.44The44remaining44options44are44not44inclusive44in44their44descriptions44of
44cellular44metabolic44absorption.
PTS:4 4 4 4 1 DIF: Cognitive44Level:44Remembering
2. Where4 4 is4 4 most4 4 of4 4 a4 4 cell’s4 4 genetic4 4 information,4 4 including4 4 RNA4 4 and4 4 DNA,4 4 contained
?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:4 4 C
The4 4 nucleus4 4 contains4 4 the4 4 nucleolus,4 4 a4 4 small4 4 dense4 4 structure4 4 composed4 4 largely4
4 of4 4 RNA,4 4 mos44t4 4 of4 4 the4 4 cellular4 4 DNA,4 4 and4 4 the4 4 DNA-
binding4 4 proteins,4 4 such4 4 as4 4 the4 4 histones,4 4 which4 4 regulate4 4 its4 4 activity.4 4 The4 4 mitoc
hondria4 4 are4 4 res44ponsible4 4 for4 4 cellular4 4 respiration4 4 and4 4 energy4 4 production.
Ribosomes’44chief44function4 4 is4 4 to44provide4 4 sites4 4 for44cellular44protein4 4 synthesis.4 4 Lysos
omes4 4 functi44on4 4 as4 4 the4 4 intracellular4 4 digestive4 4 system.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
3. Which4 4 component4 4 of4 4 the4 4 cell4 4 produces4 4 hydrogen4 4 peroxide4 4 (H2O2)4 4 by44using4
4 oxygen4 4 to4 4 re44move4 4 hydrogen4 4 atoms4 4 from4 4 specific4 4 substrates4 4 in4 4 an4 4 oxida
tive4 4 reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:4 4 B
, (8th4 4 Children
McCance:4 4 Pathophysiology:4 4 The4 4 Biologic4 4 Basis4 4 for4 4 Disease4 4 in4 4 Adults4 4 and
Edition)4 4 TEST4
4B
Peroxisomes4 4 are4 4 so4 4 named4 4 because4 4 they4 4 usually4 4 contain4 4 enzymes4 4 that4 4 use4 4 o
xygen4 4 to4 4 remo44ve4 4 hydrogen4 4 atoms4 4 from4 4 specific4 4 substrates4 4 in4 4 an4 4 oxidative4 4 r
eaction4 4 that4 4 produces4 4 H2O2,4 4 wh44ich4 4 is4 4 a4 4 powerful4 4 oxidant4 4 and4 4 potentially4 4 de
structive4 4 if4 4 it4 4 accumulates4 4 or4 4 escapes4 4 from4 4 pero44xisomes.
Ribosomes4 4 are4 4 RNA-
protein4 4 complexes4 4 (nucleoproteins)4 4 that4 4 are4 4 synthesized4 4 in4 4 the4 4 nucleolus4 4 and4 4 s
ecreted4 4 into4 4 t44he4 4 cytoplasm4 4 through4 4 pores4 4 in4 4 the4 4 nuclear4 4 envelope4 4 called4 4 nu
clear4 4 pore4 4 complexes.4 4 Lysoso44mes4 4 are4 4 saclike4 4 structures4 4 that4 4 originate4 4 from4 4 t
he4 4 Golgi4 4 complex4 4 and4 4 contain4 4 more4 4 than4 4 4044digestive4 4 enzymes4 4 called4 4 hydrol
ases,4 4 which4 4 catalyze4 4 bonds4 4 in4 4 proteins,4 4 lipids,4 4 nucleic4 4 acids
,4 4 and4 4 carbohydrates.4 4 An4 4 endosome4 4 is4 4 a4 4 vesical4 4 that4 4 has4 4 been4 4 pinched4 4 off4
4 from4 4 the4 4 cellular44membrane.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
4. Which4 4 cell4 4 component4 4 is4 4 capable4 4 of4 4 cellular4 4 autodigestion4 4 when4 4 it4 4 is4 4 released4 4 durin
g4 4 cell4 4 injury?
a. Ribosome
b. Golgi4 4 complex
c. Smooth44 endoplasmic44 reticu
lu44m
d. Lysosomes
ANS:4 4 D
The4 4 lysosomal4 4 membrane4 4 acts4 4 as4 4 a4 4 protective4 4 shield4 4 between4 4 the4 4 powerful4 4 d
igestive4 4 enzym44es44within44the44lysosome44and44the44cytoplasm,44preventing44their44leakage4
4into44the44cytoplasmic44m4 4 atrix.4 4 Disruption4 4 of4 4 the4 4 membrane4 4 by4 4 various4 4 treatme
nts4 4 or4 4 cellular4 4 injury4 4 leads4 4 to4 4 a4 4 releas44e44of44the44lysosomal44enzymes,44which44ca
n44then44react44with44their44specific44substrates,44causing44ce4 4 llular4 4 self-
digestion.4 4 The4 4 chief4 4 function4 4 of4 4 a4 4 ribosome4 4 is4 4 to4 4 provide4 4 sites4 4 for4 4 cellular4 4 protein4
4 synthesis
.4 4 The4 4 Golgi4 4 complex4 4 is4 4 a4 4 network4 4 of4 4 flattened,4 4 smooth4 4 vesicles4 4 and4 4 membra
nes4 4 often4 4 locate44d4 4 near4 4 the4 4 cell4 4 nucleus.4 4 The4 4 smooth4 4 endoplasmic4 4 reticulum4
4 is4 4 involved4 4 in4 4 steroid4 4 hormone44production4 4 and4 4 removing4 4 toxic4 4 substances4 4 fro
m4 4 the4 4 cell.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
5. Which4 4 cAMP-mediated4 4 response4 4 is4 4 related4 4 to4 4 antidiuretic4 4 hormone?
a. Increased4 4 heart4 4 rate4 4 and4 4 force44of4 4 c
ontracti44on
b. Secretion4 4 of4 4 cortisol
c. Increased4 4 retention4 4 of4 4 water
d. Breakdown4 4 of4 4 fat
ANS:4 4 C
Antidiuretic4 4 hormone4 4 leads4 4 to4 4 increased4 4 retention4 4 of4 4 water4 4 in4 4 the4 4 body.4 4 Epin
ephrine4 4 causes44increases4 4 in4 4 heart4 4 rate4 4 and4 4 force4 4 of4 4 contraction.4 4 Increased4 4 cor
tisol4 4 secretion4 4 is4 4 due4 4 to4 4 ACT
H.4 4 Breakdown4 4 of4 4 fat4 4 is4 4 due4 4 to4 4 glucagon.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
6. During4 4 which4 4 phase4 4 of4 4 the4 4 cell4 4 cycle4 4 is4 4 DNA4 4 synthesized?
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE
,McCance:44Pathophysiology:44The44Biologic44Basis44for44Disease44in44Adults44and44Children44(8th44Edi
tion)44TEST44BANK
CONTENTS:
Chapter4401:44Cellular44Biology
Chapter4402:44Altered44Cellular44and44Tissue44Biology:44Environmental44Agents
Chapter4403:44The44Cellular44Environment:44Fluids44and44Electrolytes,44Acids44and44Bases
Chapter4404:44Genes44and44Genetic44Diseases
Chapter4405:44Genes,44Environment-Lifestyle,44and44 Common44Diseases
Chapter4406:44Epigenetics44and44Disease
Chapter4407:44Innate44Immunity:44Inflammation44and44Wound44Healing
Chapter4408:44Adaptive44Immunity
Chapter4409:44Alterations44in44Immunity44and44Inflammation
Chapter4410:44Infection
Chapter4411:44Stress44and44Disease
Chapter4412:44Cancer44Biology
Chapter4413:44Cancer44Epidemiology
Chapter4414:44Cancer44in44Children
Chapter4415:44Structure44and44Function44of44the44Neurologic44System
Chapter4416:44Pain,44Temperature44Regulation,44Sleep,44and44Sensory44Function
Chapter4417:44Alterations44in44Cognitive44Systems,44Cerebral44Hemodynamics,44and44Motor44Function
Chapter4418:44Disorders44of44the44Central44and44Peripheral44Nervous44Systems44and44the44Neuromuscular44Juncti
on
Chapter4419:44Neurobiology44of44Schizophrenia,44Mood44Disorders,44and44Anxiety44Disorders
Chapter4420:44Alterations44of44Neurologic44Function44in44Children
Chapter4421:44Mechanisms44of44Hormonal44Regulation
Chapter4422:44Alterations44of44Hormonal44Regulation
Chapter4423:44Obesity44and44Disorders44of44Nutrition
Chapter4424:44Structure44and44Function44of44the44Reproductive44Systems
Chapter4425:44Alterations44of44the44Female44Reproductive44System
Chapter4426:44Alterations44of44the44Male44Reproductive44System
Chapter4427:44Sexually44Transmitted44Infections
Chapter4428:44Structure44and44Function44of44the44Hematologic44System
Chapter4429:44Alterations44of44Erythrocytes,44Platelets,44and44Hemostatic44Function
Chapter4430:44Alterations44of44Leukocyte44and44Lymphoid44Function
Chapter4431:44Alterations44of44Hematologic44Function44in44Children
Chapter4432:44Structure44and44Function44of44the44Cardiovascular44and44Lymphatic44Systems
Chapter4433:44Alterations44of44Cardiovascular44Function
Chapter4434:44Alterations44of44Cardiovascular44Function44in44Children
Chapter4435:44Structure44and44Function44of44the44Pulmonary44System
Chapter4436:44Alterations44of44Pulmonary44Function
Chapter4437:44Alterations44of44Pulmonary44Function44in44Children
Chapter4438:44Structure44and44Function44of44the44Renal44and44Urologic44Systems
Chapter4439:44Alterations44of44Renal44and44Urinary44Tract44Function
Chapter4440:44Alterations44of44Renal44and44Urinary44Tract44Function44in44Children
Chapter4441:44Structure44and44Function44of44the44Digestive44System
Chapter4442:44Alterations44of44Digestive44Function
Chapter4443:44Alterations44of44Digestive44Function44in44Children
Chapter4444:44Structure44and44Function44of44the44Musculoskeletal44System
Chapter4445:44Alterations44of44Musculoskeletal44 Function
Chapter4446:44Alterations44of44Musculoskeletal44Function44in44Children
Chapter4447:44Structure,44Function,44and44Disorders44of44the44Integument
Chapter4448:44Alterations44of44the44Integument44in44Children
Chapter4449:44Shock,44Multiple44Organ44Dysfunction44Syndrome,44and44Burns44in44Adults
Chapter4450:44Shock,44Multiple44Organ44Dysfunction44Syndrome,44and44Burns44in44Children
, (8th4 4 Children
McCance:4 4 Pathophysiology:4 4 The4 4 Biologic4 4 Basis4 4 for4 4 Disease4 4 in4 4 Adults4 4 and
Edition)4 4 TEST4
4B
Part441:44CENTRAL44CONCEPTS44OF44PATHOPHYSIOLOGY:44CELLS44AND44TISS
UES44Unit44I:44THE44CELL
CHAPTER4401:44CELLULAR44BIOLOGY
MULTIPLE44CHOICE
1. Which44statement44best44describes44the44cellular44function44of44metabolic44absorption?
a. Cells44can44produce44proteins.
b. Cells44can44secrete44digestive44enzy
mes.
c. Cells44can44take44in44and44use44nutri
ents.
d. Cells44can44synthesize44fats.
ANS:44 C
In44metabolic44absorption,44all44cells44take44in44and44use44nutrients44and44other44substances44fro
m44their44surroundings.44The44remaining44options44are44not44inclusive44in44their44descriptions44of
44cellular44metabolic44absorption.
PTS:4 4 4 4 1 DIF: Cognitive44Level:44Remembering
2. Where4 4 is4 4 most4 4 of4 4 a4 4 cell’s4 4 genetic4 4 information,4 4 including4 4 RNA4 4 and4 4 DNA,4 4 contained
?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:4 4 C
The4 4 nucleus4 4 contains4 4 the4 4 nucleolus,4 4 a4 4 small4 4 dense4 4 structure4 4 composed4 4 largely4
4 of4 4 RNA,4 4 mos44t4 4 of4 4 the4 4 cellular4 4 DNA,4 4 and4 4 the4 4 DNA-
binding4 4 proteins,4 4 such4 4 as4 4 the4 4 histones,4 4 which4 4 regulate4 4 its4 4 activity.4 4 The4 4 mitoc
hondria4 4 are4 4 res44ponsible4 4 for4 4 cellular4 4 respiration4 4 and4 4 energy4 4 production.
Ribosomes’44chief44function4 4 is4 4 to44provide4 4 sites4 4 for44cellular44protein4 4 synthesis.4 4 Lysos
omes4 4 functi44on4 4 as4 4 the4 4 intracellular4 4 digestive4 4 system.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
3. Which4 4 component4 4 of4 4 the4 4 cell4 4 produces4 4 hydrogen4 4 peroxide4 4 (H2O2)4 4 by44using4
4 oxygen4 4 to4 4 re44move4 4 hydrogen4 4 atoms4 4 from4 4 specific4 4 substrates4 4 in4 4 an4 4 oxida
tive4 4 reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:4 4 B
, (8th4 4 Children
McCance:4 4 Pathophysiology:4 4 The4 4 Biologic4 4 Basis4 4 for4 4 Disease4 4 in4 4 Adults4 4 and
Edition)4 4 TEST4
4B
Peroxisomes4 4 are4 4 so4 4 named4 4 because4 4 they4 4 usually4 4 contain4 4 enzymes4 4 that4 4 use4 4 o
xygen4 4 to4 4 remo44ve4 4 hydrogen4 4 atoms4 4 from4 4 specific4 4 substrates4 4 in4 4 an4 4 oxidative4 4 r
eaction4 4 that4 4 produces4 4 H2O2,4 4 wh44ich4 4 is4 4 a4 4 powerful4 4 oxidant4 4 and4 4 potentially4 4 de
structive4 4 if4 4 it4 4 accumulates4 4 or4 4 escapes4 4 from4 4 pero44xisomes.
Ribosomes4 4 are4 4 RNA-
protein4 4 complexes4 4 (nucleoproteins)4 4 that4 4 are4 4 synthesized4 4 in4 4 the4 4 nucleolus4 4 and4 4 s
ecreted4 4 into4 4 t44he4 4 cytoplasm4 4 through4 4 pores4 4 in4 4 the4 4 nuclear4 4 envelope4 4 called4 4 nu
clear4 4 pore4 4 complexes.4 4 Lysoso44mes4 4 are4 4 saclike4 4 structures4 4 that4 4 originate4 4 from4 4 t
he4 4 Golgi4 4 complex4 4 and4 4 contain4 4 more4 4 than4 4 4044digestive4 4 enzymes4 4 called4 4 hydrol
ases,4 4 which4 4 catalyze4 4 bonds4 4 in4 4 proteins,4 4 lipids,4 4 nucleic4 4 acids
,4 4 and4 4 carbohydrates.4 4 An4 4 endosome4 4 is4 4 a4 4 vesical4 4 that4 4 has4 4 been4 4 pinched4 4 off4
4 from4 4 the4 4 cellular44membrane.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
4. Which4 4 cell4 4 component4 4 is4 4 capable4 4 of4 4 cellular4 4 autodigestion4 4 when4 4 it4 4 is4 4 released4 4 durin
g4 4 cell4 4 injury?
a. Ribosome
b. Golgi4 4 complex
c. Smooth44 endoplasmic44 reticu
lu44m
d. Lysosomes
ANS:4 4 D
The4 4 lysosomal4 4 membrane4 4 acts4 4 as4 4 a4 4 protective4 4 shield4 4 between4 4 the4 4 powerful4 4 d
igestive4 4 enzym44es44within44the44lysosome44and44the44cytoplasm,44preventing44their44leakage4
4into44the44cytoplasmic44m4 4 atrix.4 4 Disruption4 4 of4 4 the4 4 membrane4 4 by4 4 various4 4 treatme
nts4 4 or4 4 cellular4 4 injury4 4 leads4 4 to4 4 a4 4 releas44e44of44the44lysosomal44enzymes,44which44ca
n44then44react44with44their44specific44substrates,44causing44ce4 4 llular4 4 self-
digestion.4 4 The4 4 chief4 4 function4 4 of4 4 a4 4 ribosome4 4 is4 4 to4 4 provide4 4 sites4 4 for4 4 cellular4 4 protein4
4 synthesis
.4 4 The4 4 Golgi4 4 complex4 4 is4 4 a4 4 network4 4 of4 4 flattened,4 4 smooth4 4 vesicles4 4 and4 4 membra
nes4 4 often4 4 locate44d4 4 near4 4 the4 4 cell4 4 nucleus.4 4 The4 4 smooth4 4 endoplasmic4 4 reticulum4
4 is4 4 involved4 4 in4 4 steroid4 4 hormone44production4 4 and4 4 removing4 4 toxic4 4 substances4 4 fro
m4 4 the4 4 cell.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
5. Which4 4 cAMP-mediated4 4 response4 4 is4 4 related4 4 to4 4 antidiuretic4 4 hormone?
a. Increased4 4 heart4 4 rate4 4 and4 4 force44of4 4 c
ontracti44on
b. Secretion4 4 of4 4 cortisol
c. Increased4 4 retention4 4 of4 4 water
d. Breakdown4 4 of4 4 fat
ANS:4 4 C
Antidiuretic4 4 hormone4 4 leads4 4 to4 4 increased4 4 retention4 4 of4 4 water4 4 in4 4 the4 4 body.4 4 Epin
ephrine4 4 causes44increases4 4 in4 4 heart4 4 rate4 4 and4 4 force4 4 of4 4 contraction.4 4 Increased4 4 cor
tisol4 4 secretion4 4 is4 4 due4 4 to4 4 ACT
H.4 4 Breakdown4 4 of4 4 fat4 4 is4 4 due4 4 to4 4 glucagon.
PTS: 1 DIF: Cognitive4 4 Level:4 4 Remembering
6. During4 4 which4 4 phase4 4 of4 4 the4 4 cell4 4 cycle4 4 is4 4 DNA4 4 synthesized?
