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ONS ONCC CHEMO RENEWAL Exam
Questions and Detailed Correct Answers
Already Graded A+ And 100% Guarantee
Pass Just Released 2025
1. Which of the following offers the highest risk for developing
cardiotoxicity? - correct answer -The risk of cardiotoxicity is
generally proportional to the cumulative exposure of
doxorubicin. The probability of developing cardiotoxicity is
estimated to be 1 to 2% at a total cumulative dose of 300
mg/m2 of doxorubicin, 3 to 5% at a dose of 400 mg/m2, 5 to
8% at a dose of 450 mg/m2, and 6 to 20% at a dose of 500
mg/m2, when doxorubicin is administered every 3 weeks.
There is an additive or potentially synergistic increase in the
risk of cardiotoxicity in patients who have received radiotherapy
to the mediastinum or concomitant therapy with other known
cardiotoxic agents such as cyclophosphamide, taxanes, and
trastuzumab. Cardiotoxicity can occur at lower doses in
patients who have received mediastinal radiation or those that
have underlying heart disease. Coadministration of coenzyme
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Q10 has actually shown potential benefit in decreasing
cardiotoxicity.
2. Which of the following classes of agents would you not
anticipate to be a part of Mr. Rylan's orders for premedication
to prevent CINV? - correct answer -Per the NCCN guidelines
(http://www.nccn.org/professionals/physician_gls/pdf/antiemesi
s.pdf) on Antiemesis, the most likely classes of agents that
would be used as premedication for a moderately emetic risk
regimen include: Steroids usually dexamethasone, 5HT3
antagonists like palonosetron or ondansetron, with or without
neurokinin 1 antagonists like aprepitant or fosaprepitant.
Prokinetic agents like metoclopramide are sometimes used
PRN for low risk regimens and breakthrough CINV. Other
classes of agents like proton pump inhibitors, H2 blockers, and
benzodiazepines are utilized for CINV prevention and control
as well and sometimes are included as premedications prior to
chemotherapy.
3. The next thing you discuss with Mr. Rylan is neutropenia and
the risk for infection that goes along with it. You state that you
will monitor his blood counts closely and that his physician may
decide to use a colony-stimulating factor to enhance his
neutrophil count. You review some of the things that Mr. Rylan
can do to hopefully prevent getting an infection like good hand
washing. - correct answer -Avoiding fresh fruits and vegetables
is no longer recommended to prevent infection. Fresh fruits and
, Page | 3
vegetables can and should be eaten as long as they are
washed thoroughly.
4. What is the most important toxicity that you will monitor for
with rituximab especially since this is the patient's first dose of
the agent? - correct answer -Although all the other answers
listed can happen with rituximab, you are most concerned
about the potential for a hypersensitivity reaction since this is
rituximab and it is the patient's first dose.
5. Which of the following medications is the likely cause of Mr.
Rylan's constipation? - correct answer -Oncovin (vincristine)
can cause neurotoxicity of the smooth muscle of the GI tract
which can lead to decreased peristalsis and paralytic ileus.
Constipation, abdominal pain, and paralytic ileus can be seen
with vincristine use.
6. Which of the agents that Mr. Rylan is receiving in R-CHOP
would be the likely culprit if this is hemorrhagic cystitis? -
correct answer -A dose-limiting toxicity of cyclophosphamide is
hemorrhagic cystitis. Although it is more commonly seen with
high-dose therapy, it can still occur in patients receiving R-
CHOP.
ONS ONCC CHEMO RENEWAL Exam
Questions and Detailed Correct Answers
Already Graded A+ And 100% Guarantee
Pass Just Released 2025
1. Which of the following offers the highest risk for developing
cardiotoxicity? - correct answer -The risk of cardiotoxicity is
generally proportional to the cumulative exposure of
doxorubicin. The probability of developing cardiotoxicity is
estimated to be 1 to 2% at a total cumulative dose of 300
mg/m2 of doxorubicin, 3 to 5% at a dose of 400 mg/m2, 5 to
8% at a dose of 450 mg/m2, and 6 to 20% at a dose of 500
mg/m2, when doxorubicin is administered every 3 weeks.
There is an additive or potentially synergistic increase in the
risk of cardiotoxicity in patients who have received radiotherapy
to the mediastinum or concomitant therapy with other known
cardiotoxic agents such as cyclophosphamide, taxanes, and
trastuzumab. Cardiotoxicity can occur at lower doses in
patients who have received mediastinal radiation or those that
have underlying heart disease. Coadministration of coenzyme
, Page | 2
Q10 has actually shown potential benefit in decreasing
cardiotoxicity.
2. Which of the following classes of agents would you not
anticipate to be a part of Mr. Rylan's orders for premedication
to prevent CINV? - correct answer -Per the NCCN guidelines
(http://www.nccn.org/professionals/physician_gls/pdf/antiemesi
s.pdf) on Antiemesis, the most likely classes of agents that
would be used as premedication for a moderately emetic risk
regimen include: Steroids usually dexamethasone, 5HT3
antagonists like palonosetron or ondansetron, with or without
neurokinin 1 antagonists like aprepitant or fosaprepitant.
Prokinetic agents like metoclopramide are sometimes used
PRN for low risk regimens and breakthrough CINV. Other
classes of agents like proton pump inhibitors, H2 blockers, and
benzodiazepines are utilized for CINV prevention and control
as well and sometimes are included as premedications prior to
chemotherapy.
3. The next thing you discuss with Mr. Rylan is neutropenia and
the risk for infection that goes along with it. You state that you
will monitor his blood counts closely and that his physician may
decide to use a colony-stimulating factor to enhance his
neutrophil count. You review some of the things that Mr. Rylan
can do to hopefully prevent getting an infection like good hand
washing. - correct answer -Avoiding fresh fruits and vegetables
is no longer recommended to prevent infection. Fresh fruits and
, Page | 3
vegetables can and should be eaten as long as they are
washed thoroughly.
4. What is the most important toxicity that you will monitor for
with rituximab especially since this is the patient's first dose of
the agent? - correct answer -Although all the other answers
listed can happen with rituximab, you are most concerned
about the potential for a hypersensitivity reaction since this is
rituximab and it is the patient's first dose.
5. Which of the following medications is the likely cause of Mr.
Rylan's constipation? - correct answer -Oncovin (vincristine)
can cause neurotoxicity of the smooth muscle of the GI tract
which can lead to decreased peristalsis and paralytic ileus.
Constipation, abdominal pain, and paralytic ileus can be seen
with vincristine use.
6. Which of the agents that Mr. Rylan is receiving in R-CHOP
would be the likely culprit if this is hemorrhagic cystitis? -
correct answer -A dose-limiting toxicity of cyclophosphamide is
hemorrhagic cystitis. Although it is more commonly seen with
high-dose therapy, it can still occur in patients receiving R-
CHOP.
