Stahl’s Essential Psychopharmacology 5th Edition – 100 Practice Questions and Answers | Clinical Application and Exam Prep

Stahl’s Essential Psychopharmacology 5th
Edition – 100 Practice Questions and
Answers

Antidepressants (1–20)
1. Which class of antidepressants is most associated with sexual dysfunction?
A) SSRIs
B) MAOIs
C) Bupropion
D) Mirtazapine
Answer: A (SSRIs commonly cause sexual dysfunction.)
2. Which antidepressant is known for causing the least sexual side effects?
A) Paroxetine
B) Bupropion
C) Sertraline
D) Fluoxetine
Answer: B (Bupropion is least likely to cause sexual dysfunction.)
3. Which SSRI has the longest half-life?
A) Paroxetine
B) Sertraline
C) Fluoxetine
D) Citalopram
Answer: C (Fluoxetine has the longest half-life.)
4. Which antidepressant is also indicated for smoking cessation?
A) Escitalopram
B) Bupropion
C) Venlafaxine
D) Mirtazapine
Answer: B (Bupropion.)
5. Which TCA is most anticholinergic?
A) Amitriptyline
B) Nortriptyline
C) Desipramine
D) Doxepin
Answer: A (Amitriptyline.)
6. Which antidepressant is most sedating?
A) Bupropion
B) Mirtazapine
C) Fluoxetine
D) Venlafaxine
Answer: B (Mirtazapine.)
7. What is a common side effect of SNRIs?
A) Hypertension
B) Weight gain

, C) Hyperprolactinemia
D) Bradycardia
Answer: A (SNRIs can increase blood pressure.)
8. Which antidepressant is most associated with weight gain?
A) Paroxetine
B) Bupropion
C) Venlafaxine
D) Sertraline
Answer: A (Paroxetine.)
9. Which antidepressant is most likely to cause dose-dependent hypertension?
A) Duloxetine
B) Mirtazapine
C) Venlafaxine
D) Trazodone
Answer: C (Venlafaxine.)
10. Which antidepressant should not be combined with MAOIs due to serotonin
syndrome risk?
A) Bupropion
B) Fluoxetine
C) Mirtazapine
D) Trazodone
Answer: B (Fluoxetine, as an SSRI.)
11. What is the mechanism of action for SSRIs?
Answer: Block reuptake of serotonin.
12. Which antidepressant is also an alpha-2 antagonist?
A) Bupropion
B) Mirtazapine
C) Trazodone
D) Paroxetine
Answer: B (Mirtazapine.)
13. Which antidepressant can cause priapism?
A) Sertraline
B) Trazodone
C) Amitriptyline
D) Bupropion
Answer: B (Trazodone.)
14. Which SNRI is FDA-approved for diabetic neuropathy?
A) Venlafaxine
B) Duloxetine
C) Desvenlafaxine
D) Milnacipran
Answer: B (Duloxetine.)
15. Which antidepressant is most likely to cause a withdrawal syndrome if stopped
abruptly?
A) Paroxetine
B) Bupropion
C) Fluoxetine
D) Mirtazapine
Answer: A (Paroxetine, due to short half-life.)