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1. neovascularization of the retina has a risk of what? - ANSWER✓ vitreous
hemorrhage (as well as traction retinal detachment)
2. neovascularization commonly occurs in cental retinal vein occlusion ("blood
and thunder")
3. which immunoglobin is associated with urticaria? - ANSWER✓ IgE
4. preferred treatment for toxoplasmosis - ANSWER✓ sulfadiazine and
pyrimethamine
5. what exactly causes the occlusive vascular disease of thromboangiitis
obliterans? - ANSWER✓ aka Buerger's disease
inflammatory thrombi affecting the medium and small vessels
(nonatherosclerosis)
, polymorphonuclear leukocytes, microabscesses, and multinucleated giant
cells may be presen
6. Treatment options for thromboangiitis obliterans? - ANSWER✓ smoking
cessation most important!
cilostazol (PDE 3 inhibitor) has vasodilator properties (alleviated symptoms)
if raynauds also present, CCB (nifedipine)
7. what heart failure treatment provides a benefit of reduction in morbidity and
mortality? - ANSWER✓ ACE inhibitors
beta blockers can also reduce M&M
diuretics have no reduction in mortality
8. how would you manage a patient with a MI in the setting of cocaine use? -
ANSWER✓ benzodiazepine early
no beta blockers
9. If PCI cannot be done for a STEMI patient within 120 minutes, what should
be done? - ANSWER✓ fibrolytic therapy
then do PCI & coronary angiography when it can be done
ideally PCI is done within 90 minutes
fibrolytic therapy can be used up to 12 hours of symptoms
10. If you suspect an acute limb ischemia due to arterial embolism, what
imaging should you get? - ANSWER✓ catheter-based arteriography (digital
subtraction arteriography) provides the most useful information. can also
help with treatment
can help distinguish between thrombosis and embolus
11. where are arterial emboli often found? - ANSWER✓ lower extremities more
common than upper extremities
The common femoral, common iliac, and popliteal artery bifurcations are
frequent locations
, majority originate in the heart
fun fact: Compared with thromboemboli, atheroemboli are less likely to
produce symptoms of acute limb ischemia
12. how would you work up a patient with treatment resistant hypertension that
you suspect a secondary cause? - ANSWER✓ 24-hour ambulatory
monitoring (to ensure not white coat)
medical hx (assess adherence to meds, other meds)
physical exam (look for abominal/renal bruits)
labs (electrolytes, glucose, creatinine, UA)
If pheo suspected: measure fractionated metanephrines and catecholamines
in a 24-hour urine collection
13. other than atherosclerosis leading to renal artery stenosis and secondary
HTN, what is another causes of a renal-associated secondary HTN? -
ANSWER✓ fibromuscular dysplasia (usually in a young pt)
14. most important modifable risk factor for AAA? - ANSWER✓ smoking
cessation!
15. when is it okay to do screening survelliance for AAA rather than repair and
how often should you screen? - ANSWER✓ if AAA is <5.5 cm then annual
screening with US is recommended. may need every 6 months if rapidly
expanding or other concerns
16. besides glucose control, what are some other measures to help reduce the
incidence of diabetic retinopathy? - ANSWER✓ blood pressure control
Statin therapy for dyslipidemia
17. when does nystagmus occur in the Dix Hallpike manuever in a pt with
BPPV? how would you describe the eye movement? - ANSWER✓ when the
pt is laid back the nystagmus and vertigo typically occur a few seconds later
and lasts less than 30 seconds
Nystagmus direction depends on the canal involved. Posterior and anterior
canals typically have a torsional aspect
, 18. what are some symptoms commonly associated with anemia related to
B12/folate deficiency? - ANSWER✓ shortness of breath & CP (severe
anemia), fatigue, irritability, cognitive decline, palpitations, pallor
19. what are some GI tract sx associated with B12 and folate deficiencies? -
ANSWER✓ B12 - glossitis (including pain, swelling, tenderness, and loss of
papillae of the tongue)
folate - oral ulcers
20. what serum level can help differentiate folate from B12 deficiency? -
ANSWER✓ elevated homocysteine with a normal MMA (methylmalonic
acid)
both elevated homocysteine and MMA is a B12 deficiency, but additional
folate deficiency cannot be ruled out
21. what is factor V's role in the clotting cascade? - ANSWER✓ procoagulant
clotting factor that amplifies the production of thrombin, the central enzyme
that converts fibrinogen to fibrin
A small amount of thrombin at the site of a wound activates factor V by
limited proteolysis. Works as a positive feedback loop
22. What is occuring in Factor V Leiden that leads to increased risk of VTE? -
ANSWER✓ a single point mutation of the factor V gene leads to factor V
being insensitive to protein C (which is a natural anticoagulant)
23. what anti-nausea medication is suggested for treatment of concussion?
which should be avoided? - ANSWER✓ ondansetron is recommended for
the first 1-2 days post-concussion
avoid phenothiazines (metoclopromide & promethazine) due to adverse SEs
such as drowsiness and orthostatic hypotension
24. what route of administration should antibiotics be given for bacterial
meningitis? What should be given along side the antibiotics while treating
empirically? - ANSWER✓ IV works best to help better penetrate the BBB.