TEST BANK
Genetics and Genomics in Nursing and Health Care
Theresa A. Beery, M. Linda Workman, and Julia A. Eggert
2nd Edition
www.Plusbay.Plus
,TabledlofdlContents
Chapterdl01dlDNAdlStructuredlanddlFunction 1
Chapterdl02dlProteindlSynthesis 9
Chapterdl03dlGeneticdlInfluencedlondlCelldlDivision,dlDifferentiation,dlanddlGametogenesis 19
Chapterdl04dlPatternsdlofdlInheritance 29
Chapterdl05dlEpigeneticdlInfluencesdlondlGenedlExpression 43
Chapterdl06dlAutosomaldlInheritancedlanddlDisorders 47
Chapterdl07dlSexdlChromosomedlanddlMitochondrialdlInheritancedlanddlDisorders 55
Chapterdl08dlFamilydlHistorydlanddlPedigreedlConstruction 61
Chapterdl09dlCongenitaldlAnomalies,dlBasicdlDysmorphology,dlanddlGeneticdlAssessment 68
Chapterdl10dlEnzymedlanddlCollagendlDisorders 74
Chapterdl11dlCommondlChildhood-OnsetdlGeneticdlDisorders 84
Chapterdl12dlCommondlAdult-OnsetdlDisorders 95
Chapterdl13dlCardiovasculardlDisorders 103
Chapterdl14dlThedlGeneticsdlofdlCancer 110
Chapterdl15dlGeneticdlContributionsdltodlPsychiatricdlanddlBehavioraldlDisorders 119
Chapterdl16dlGeneticdlanddlGenomicdlTesting 124
Chapterdl17dlAssessingdlGenomicdlVariationdlindlDrugdlResponse 129
Chapterdl18dlHealthdlProfessionalsdlanddlGenomicdlCare 135
Chapterdl19dlFinancial,dlEthical,dlLegal,dlanddlSocialdlConsiderations 140
Chapterdl20dlGeneticdlanddlGenomicdlVariation 144
www.Plusbay.Plus
, TestdlBankdl-
dlGeneticsdlanddlGenomicsdlindlNursingdlanddlHealthdlCare,dl2nddlEditiondl(Beery,dl2019)
Chapterdl1:dlDNAdlStructuredlanddlFunction
MULTIPLEdlCHOICE
1. Indlwhichdlbodydlordlcelldlareadlaredlmostdlgenesdlindlhumansdllocated?
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. Plasmadlmembrane
ANS:d l d l A
MostdlgenesdlaredlpartdlofdlthedlDNAdllocateddlindlthedlnucleusdlofdlbodydlcells.dlOnlydladlfewdlg
enesdlaredllocateddlindladlcell’sdlmitochondriondlordlmitochondria.dlTheredlaredlnodlgenesdlordlDN
Adlindleitherdlthedlcytoplasmdlordlthedlplasmadlmembranesdlofdlanydlcell.
2. Whichdlconditiondlordlstatementdlexemplifiesdlthedlconceptdlofdlgenomicsdlratherdlthandlgenetics?
a. Thedlgenedlfordlinsulindlisdllocateddlondlchromosomedl11dlindlalldlpeople.
b. Expressiondlofdlanydlsingledlgenedlisdldependentdlondlinheritingdltwodlalleles.
c. Sex-linkeddlrecessivedldisordersdlaffectdlmalesdlmoredloftendlthandlfemales.
d. Onedlalleledlfordleachdlgenedlisdlinheriteddlfromdlthedlmother,dlanddlonedlisdlinheritedd
lfromdlthedlfather.
ANS:d l d l A
Geneticsdlisdlthedlstudydlofdlthedlgeneraldlmechanismsdlofdlhereditydlanddlthedlvariationdlofdlin
heriteddltraits.dlGenomicsdlisdlthedlstudydlofdlthedlfunctiondlofdlalldlthedlnucleotidedlsequencesd
lpresentdlwithindlthedlentiredlgenomedlofdladls p e c i e s , i n c l u d i n g dlgenes indl DNAdlcodingdlregi
W W W . T B SM.WS
onsdlanddlDNAdlnoncoding
regions.dlSelectionsdlB,dlC,dlanddlDdlalldlreferdltodlmechanismsdlofdlheredity.dlOnlydlselectiondlAdlr
efers
todlthedlfunctiondlofdladlspecificdlnucleotidedlsequence.
3. WhatdlisdlthedlpurposedlofdlphosphorousdlindladlDNAdlstrand?
a. Linkingdlthedlnucleotidesdlintodladlstrand
b. Holdingdlcomplementarydlstrandsdltogether
c. Ensuringdlthatdladlpurinedlisdlalwaysdlpaireddlwithdladlpyrimidine
d. Preventingdlthedlseparationdlofdldouble-strandeddlDNAdlintodlsingle-strandeddlDNA
ANS:d l d l A
Eachdlnucleosidedlbecomesdladlcompletedlnucleotidedlwhendladlphosphatedlgroupdlisdlattached.
dlThedlphosphatesdlhavedlmultipledlbindingdlsites,dlanddleachdlonedlcandllinkdltodltwodlnucleoti
des.dlThesedllinkagesdlallowdlthedlnucleotidesdltodlbedlconnecteddlwhendlplaceddlintodlthedlD
NAdlstrand.dlThedlnucleotidesdlwithindleachdlstranddlaredlhelddlindlpositiondlbydlthedllinkeddlp
hosphatedlgroups,dlwhichdlactdllikedlthedlstringdlholdingdladlstranddlofdlbeadsdltogether,dlformi
ngdladlnecklace.
4. Whatdlisdlthedltermdluseddltodldefinedlalternativedlformsdlofdladlgenedlthatdlmaydlresultdlin
dldifferentdlexpressiondlofdlthedltraitdlcodeddlfordlbydlthatdlgene?
a. Alleles
b. Bases
c. Centromeres
d. Diploids
dlANS:d l A
www.Plusbay.Plus 1dl|dlPdladlgdl
e
, TestdlBankdl-
dlGeneticsdlanddlGenomicsdlindlNursingdlanddlHealthdlCare,dl2nddlEditiondl(Beery,dl2019)
Fordleachdlsingledlgene,dltwodlalternativedlformsdlofdlthatdlgene,dlknowndlasdlalleles,dltogetherd
lcontroldlhowdlthatdlgenedlisdlexpressed.dlThedlallelesdlmaydlbedlidenticaldlindltheirdlsequencedlb
utdldodlnotdlhavedltodlbe.dlWhendladldominantdlalleledlisdlpaireddlwithdladlrecessivedlallele,dlonl
ydlthedldominantdlalleledlisdlexpressed,dlanddlthedlrecessivedlalleledlisdlsilent.dlWhendladldomin
antdlalleledlisdlpaireddlwithdlanotherdldominantdlallele,dltheydlaredlbothdlexpresseddl(usuallydle
qually).dlRecessivedlallelesdlaredlonlydlexpresseddlwhendltheydlaredlhomozygous.dlBasesdlaredl
thedlessentialdlpartdlofdladlnucleotide,dlofdlwhichdltheredlaredlmanydlwithindlanydlgenedlregion.d
lCentromeresdlaredlthedlpinched-
indlpartdlofdladlchromosomedlbetweendlthedlpdlarmsdlanddlthedlqdlarms.dlThedltermdldiploiddlref
ersdltodlthedlnormaldlnumberdlofdlchromosomedlpairsdlwithindladlcell.dlItdlisdlandladjective,dlnot
dladlnoun.dlTherefore,dlthedlpluraldldiploidsdldoesdlnotdlexist.
5. Whatdlpercentagedlofdlbasesdlindladlstretchdlofdldouble-
strandeddlDNAdlthatdlcontainsdl30%dlguanine
(G)dlbasesdlwoulddlbedladeninedl(A)?
a. 70%
b. 60%
c. 30%
d. 20%
ANS:d l d l D
Becausedlofdlcomplementarydlpairing,dlifdl30%dlofdlthedlbasesdlaredlguaninedl(G),dlwhichdlalways
dlpairsdlwithdlcytosinedlC,dlthesedltwodlbasesdlaccountdlfordl60%dlofdlthedltotaldlbasesdlindlthisdlstr
etch.dlThedlremainingdlbasesdlmakedlupdl40%dlofdlthedltotal.dlThisdl40%dlisdlcomposeddlofdlequal
dlpercentagesdlofdlthyminedl(T)dlanddladeninedl(A).
6. Whatdlisdlthedltermdluseddltodldescribedlthedlorganizeddlpicturedlofdlthedlpaireddlchromosomes
dlwithindladlcelldluseddltodldeterminedlwhetherdlchromosomedlnumbers,dlstructures,dlanddlban
dingdlpatternsdlare
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS:d l d l C
Adlkaryotypedlisdladlpicturedlofdlandlorganizeddlarrangementdlofdlalldlofdlthedlchromosomesdlwi
thindlonedlcelldlduringdlthedlmetaphasedlsectiondlofdlmitosis.dlThedlchromosomesdlaredlpaireddla
nddlthendlarrangeddlbydlnumberdlaccordingdltodlsizedlanddlcentromeredlposition.dlThedlbanding
dlpatterndlofdleachdlpairdlisdlanalyzeddltodldeterminedlwhetherdlareasdlhavedlbeendldeleted,dlexp
anded,dlordltranslocated.dlAdlpedigreedlalsodlisdladlpicture,dlbutdlitdlillustratesdlseveraldlgenerati
onsdlofdladlfamilydlhistory.
Phenotypesdlaredlobservabledltraits.dlAutotypedlisdlnotdladlgeneticdlterm.
7. WhatdlwoulddlbedlthedlsequencedlofdlDNAdlthatdlisdlcomplementarydltodladlDNAdlsectiondlwith
dlthedlbasedlsequencedlofdlGGTCAATCCTTAG?
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC
dlANS:d l D
www.Plusbay.Plus 2dl|dlPdladlgdl
e
Genetics and Genomics in Nursing and Health Care
Theresa A. Beery, M. Linda Workman, and Julia A. Eggert
2nd Edition
www.Plusbay.Plus
,TabledlofdlContents
Chapterdl01dlDNAdlStructuredlanddlFunction 1
Chapterdl02dlProteindlSynthesis 9
Chapterdl03dlGeneticdlInfluencedlondlCelldlDivision,dlDifferentiation,dlanddlGametogenesis 19
Chapterdl04dlPatternsdlofdlInheritance 29
Chapterdl05dlEpigeneticdlInfluencesdlondlGenedlExpression 43
Chapterdl06dlAutosomaldlInheritancedlanddlDisorders 47
Chapterdl07dlSexdlChromosomedlanddlMitochondrialdlInheritancedlanddlDisorders 55
Chapterdl08dlFamilydlHistorydlanddlPedigreedlConstruction 61
Chapterdl09dlCongenitaldlAnomalies,dlBasicdlDysmorphology,dlanddlGeneticdlAssessment 68
Chapterdl10dlEnzymedlanddlCollagendlDisorders 74
Chapterdl11dlCommondlChildhood-OnsetdlGeneticdlDisorders 84
Chapterdl12dlCommondlAdult-OnsetdlDisorders 95
Chapterdl13dlCardiovasculardlDisorders 103
Chapterdl14dlThedlGeneticsdlofdlCancer 110
Chapterdl15dlGeneticdlContributionsdltodlPsychiatricdlanddlBehavioraldlDisorders 119
Chapterdl16dlGeneticdlanddlGenomicdlTesting 124
Chapterdl17dlAssessingdlGenomicdlVariationdlindlDrugdlResponse 129
Chapterdl18dlHealthdlProfessionalsdlanddlGenomicdlCare 135
Chapterdl19dlFinancial,dlEthical,dlLegal,dlanddlSocialdlConsiderations 140
Chapterdl20dlGeneticdlanddlGenomicdlVariation 144
www.Plusbay.Plus
, TestdlBankdl-
dlGeneticsdlanddlGenomicsdlindlNursingdlanddlHealthdlCare,dl2nddlEditiondl(Beery,dl2019)
Chapterdl1:dlDNAdlStructuredlanddlFunction
MULTIPLEdlCHOICE
1. Indlwhichdlbodydlordlcelldlareadlaredlmostdlgenesdlindlhumansdllocated?
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. Plasmadlmembrane
ANS:d l d l A
MostdlgenesdlaredlpartdlofdlthedlDNAdllocateddlindlthedlnucleusdlofdlbodydlcells.dlOnlydladlfewdlg
enesdlaredllocateddlindladlcell’sdlmitochondriondlordlmitochondria.dlTheredlaredlnodlgenesdlordlDN
Adlindleitherdlthedlcytoplasmdlordlthedlplasmadlmembranesdlofdlanydlcell.
2. Whichdlconditiondlordlstatementdlexemplifiesdlthedlconceptdlofdlgenomicsdlratherdlthandlgenetics?
a. Thedlgenedlfordlinsulindlisdllocateddlondlchromosomedl11dlindlalldlpeople.
b. Expressiondlofdlanydlsingledlgenedlisdldependentdlondlinheritingdltwodlalleles.
c. Sex-linkeddlrecessivedldisordersdlaffectdlmalesdlmoredloftendlthandlfemales.
d. Onedlalleledlfordleachdlgenedlisdlinheriteddlfromdlthedlmother,dlanddlonedlisdlinheritedd
lfromdlthedlfather.
ANS:d l d l A
Geneticsdlisdlthedlstudydlofdlthedlgeneraldlmechanismsdlofdlhereditydlanddlthedlvariationdlofdlin
heriteddltraits.dlGenomicsdlisdlthedlstudydlofdlthedlfunctiondlofdlalldlthedlnucleotidedlsequencesd
lpresentdlwithindlthedlentiredlgenomedlofdladls p e c i e s , i n c l u d i n g dlgenes indl DNAdlcodingdlregi
W W W . T B SM.WS
onsdlanddlDNAdlnoncoding
regions.dlSelectionsdlB,dlC,dlanddlDdlalldlreferdltodlmechanismsdlofdlheredity.dlOnlydlselectiondlAdlr
efers
todlthedlfunctiondlofdladlspecificdlnucleotidedlsequence.
3. WhatdlisdlthedlpurposedlofdlphosphorousdlindladlDNAdlstrand?
a. Linkingdlthedlnucleotidesdlintodladlstrand
b. Holdingdlcomplementarydlstrandsdltogether
c. Ensuringdlthatdladlpurinedlisdlalwaysdlpaireddlwithdladlpyrimidine
d. Preventingdlthedlseparationdlofdldouble-strandeddlDNAdlintodlsingle-strandeddlDNA
ANS:d l d l A
Eachdlnucleosidedlbecomesdladlcompletedlnucleotidedlwhendladlphosphatedlgroupdlisdlattached.
dlThedlphosphatesdlhavedlmultipledlbindingdlsites,dlanddleachdlonedlcandllinkdltodltwodlnucleoti
des.dlThesedllinkagesdlallowdlthedlnucleotidesdltodlbedlconnecteddlwhendlplaceddlintodlthedlD
NAdlstrand.dlThedlnucleotidesdlwithindleachdlstranddlaredlhelddlindlpositiondlbydlthedllinkeddlp
hosphatedlgroups,dlwhichdlactdllikedlthedlstringdlholdingdladlstranddlofdlbeadsdltogether,dlformi
ngdladlnecklace.
4. Whatdlisdlthedltermdluseddltodldefinedlalternativedlformsdlofdladlgenedlthatdlmaydlresultdlin
dldifferentdlexpressiondlofdlthedltraitdlcodeddlfordlbydlthatdlgene?
a. Alleles
b. Bases
c. Centromeres
d. Diploids
dlANS:d l A
www.Plusbay.Plus 1dl|dlPdladlgdl
e
, TestdlBankdl-
dlGeneticsdlanddlGenomicsdlindlNursingdlanddlHealthdlCare,dl2nddlEditiondl(Beery,dl2019)
Fordleachdlsingledlgene,dltwodlalternativedlformsdlofdlthatdlgene,dlknowndlasdlalleles,dltogetherd
lcontroldlhowdlthatdlgenedlisdlexpressed.dlThedlallelesdlmaydlbedlidenticaldlindltheirdlsequencedlb
utdldodlnotdlhavedltodlbe.dlWhendladldominantdlalleledlisdlpaireddlwithdladlrecessivedlallele,dlonl
ydlthedldominantdlalleledlisdlexpressed,dlanddlthedlrecessivedlalleledlisdlsilent.dlWhendladldomin
antdlalleledlisdlpaireddlwithdlanotherdldominantdlallele,dltheydlaredlbothdlexpresseddl(usuallydle
qually).dlRecessivedlallelesdlaredlonlydlexpresseddlwhendltheydlaredlhomozygous.dlBasesdlaredl
thedlessentialdlpartdlofdladlnucleotide,dlofdlwhichdltheredlaredlmanydlwithindlanydlgenedlregion.d
lCentromeresdlaredlthedlpinched-
indlpartdlofdladlchromosomedlbetweendlthedlpdlarmsdlanddlthedlqdlarms.dlThedltermdldiploiddlref
ersdltodlthedlnormaldlnumberdlofdlchromosomedlpairsdlwithindladlcell.dlItdlisdlandladjective,dlnot
dladlnoun.dlTherefore,dlthedlpluraldldiploidsdldoesdlnotdlexist.
5. Whatdlpercentagedlofdlbasesdlindladlstretchdlofdldouble-
strandeddlDNAdlthatdlcontainsdl30%dlguanine
(G)dlbasesdlwoulddlbedladeninedl(A)?
a. 70%
b. 60%
c. 30%
d. 20%
ANS:d l d l D
Becausedlofdlcomplementarydlpairing,dlifdl30%dlofdlthedlbasesdlaredlguaninedl(G),dlwhichdlalways
dlpairsdlwithdlcytosinedlC,dlthesedltwodlbasesdlaccountdlfordl60%dlofdlthedltotaldlbasesdlindlthisdlstr
etch.dlThedlremainingdlbasesdlmakedlupdl40%dlofdlthedltotal.dlThisdl40%dlisdlcomposeddlofdlequal
dlpercentagesdlofdlthyminedl(T)dlanddladeninedl(A).
6. Whatdlisdlthedltermdluseddltodldescribedlthedlorganizeddlpicturedlofdlthedlpaireddlchromosomes
dlwithindladlcelldluseddltodldeterminedlwhetherdlchromosomedlnumbers,dlstructures,dlanddlban
dingdlpatternsdlare
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS:d l d l C
Adlkaryotypedlisdladlpicturedlofdlandlorganizeddlarrangementdlofdlalldlofdlthedlchromosomesdlwi
thindlonedlcelldlduringdlthedlmetaphasedlsectiondlofdlmitosis.dlThedlchromosomesdlaredlpaireddla
nddlthendlarrangeddlbydlnumberdlaccordingdltodlsizedlanddlcentromeredlposition.dlThedlbanding
dlpatterndlofdleachdlpairdlisdlanalyzeddltodldeterminedlwhetherdlareasdlhavedlbeendldeleted,dlexp
anded,dlordltranslocated.dlAdlpedigreedlalsodlisdladlpicture,dlbutdlitdlillustratesdlseveraldlgenerati
onsdlofdladlfamilydlhistory.
Phenotypesdlaredlobservabledltraits.dlAutotypedlisdlnotdladlgeneticdlterm.
7. WhatdlwoulddlbedlthedlsequencedlofdlDNAdlthatdlisdlcomplementarydltodladlDNAdlsectiondlwith
dlthedlbasedlsequencedlofdlGGTCAATCCTTAG?
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC
dlANS:d l D
www.Plusbay.Plus 2dl|dlPdladlgdl
e
