GNRS 584 Mental Health - Week 3 - Intro to
Psych Meds Part 2 Questions With Complete
Solutions
____ transforms may drugs into active metabolites-
chemicals that have active pharmacological
actions.
Researchers use this information in the designing
of new drugs making use of the body's own
mechanisms to activate a chemical for
pharmacological use. Correct Answers Liver
-Approved by the FDA for maintenance therapy of
bipolar disorder.
-Works well at treating the depression of bipolar
disorder.
-Less incidence of switching patients to mania than
antidepressants,
-Rashes could be a sign of life-threatening Stevens-
Johnson syndrome. Correct Answers Lamictal
(lamotrigine) - anticonvulsant
-Boosts Chloride conductance through GABA-
regulated channels.
-Inhibitory actions in sleep centers may provide
sedative hypnotic effects.
Expected effects:
-Improves quality of sleep; effects on total awake-
time and number of nighttime awakenings may be
,decreased over time. Correct Answers Sedative
Hypnotics
-Does not cause sexual side effects as it has no
serotonin action.
-Common side effects are: insomnia, tremor,
anorexia, and weight loss.
-Contraindicated in patients with a seizure
disorder, or patients with a current or past
diagnosis of an eating disorder.
-Also contraindicated in patients undergoing
alcohol or sedative withdrawal (Benzodiazepines )
due to an increase in risk of seizures. Correct
Answers Wellbutrin (Bupropion)
Also called Zyban
-Drugs act by inhibiting the enzyme MAO and
interfering in the destruction of the monoamine
neurotransmitters, increasing the synaptic level of
the neurotransmitters and making possible the
antidepressant effects.
-MAO in the liver is responsible for degrading
monoamine substances that enter the body via
food or drugs.
-Tyramine is a monoamine that is present in many
food substances: aged cheese, smoked fish, and
wine.
-Tyramine poses a threat of hypertensive crisis
because it can produce significant vasoconstriction
causing an elevation in blood pressure if allowed to
, circulate freely in the blood. Correct Answers
Monoamine Oxidase Inhibitors (MAOIs)
-Drugs that prevent the destruction of monoamines
by inhibiting the action of MAO. (monoamine
oxidase)
-The enzyme MAO degrades monoamine
neurotransmitters and food substances or drugs.
-MAO is located in neurons and in the liver. Correct
Answers Monoamine Oxidase Inhibitors (MAOIs)
-Efficacy is well established by research
-Not entirely sure how it works but believe that
because it is a positively charged ion much like
sodium and potassium, it may act by affecting
electrical conductivity in neurons.
-May reduce the excitatory neurotransmitter
glutamate.
-Noncompetitive inhibition of the enzyme inostitol
monophosphatase
-Possibly causes inhibition of serotonin
autoreceptors. Correct Answers Lithium
-Increase both serotonin and norepinephrine.
-In this class of drugs the mechanism of action is
dependent on the drug. Correct Answers
Serotonin-Norepinephrine Reuptake Inhibitors
(SNRIs)
Psych Meds Part 2 Questions With Complete
Solutions
____ transforms may drugs into active metabolites-
chemicals that have active pharmacological
actions.
Researchers use this information in the designing
of new drugs making use of the body's own
mechanisms to activate a chemical for
pharmacological use. Correct Answers Liver
-Approved by the FDA for maintenance therapy of
bipolar disorder.
-Works well at treating the depression of bipolar
disorder.
-Less incidence of switching patients to mania than
antidepressants,
-Rashes could be a sign of life-threatening Stevens-
Johnson syndrome. Correct Answers Lamictal
(lamotrigine) - anticonvulsant
-Boosts Chloride conductance through GABA-
regulated channels.
-Inhibitory actions in sleep centers may provide
sedative hypnotic effects.
Expected effects:
-Improves quality of sleep; effects on total awake-
time and number of nighttime awakenings may be
,decreased over time. Correct Answers Sedative
Hypnotics
-Does not cause sexual side effects as it has no
serotonin action.
-Common side effects are: insomnia, tremor,
anorexia, and weight loss.
-Contraindicated in patients with a seizure
disorder, or patients with a current or past
diagnosis of an eating disorder.
-Also contraindicated in patients undergoing
alcohol or sedative withdrawal (Benzodiazepines )
due to an increase in risk of seizures. Correct
Answers Wellbutrin (Bupropion)
Also called Zyban
-Drugs act by inhibiting the enzyme MAO and
interfering in the destruction of the monoamine
neurotransmitters, increasing the synaptic level of
the neurotransmitters and making possible the
antidepressant effects.
-MAO in the liver is responsible for degrading
monoamine substances that enter the body via
food or drugs.
-Tyramine is a monoamine that is present in many
food substances: aged cheese, smoked fish, and
wine.
-Tyramine poses a threat of hypertensive crisis
because it can produce significant vasoconstriction
causing an elevation in blood pressure if allowed to
, circulate freely in the blood. Correct Answers
Monoamine Oxidase Inhibitors (MAOIs)
-Drugs that prevent the destruction of monoamines
by inhibiting the action of MAO. (monoamine
oxidase)
-The enzyme MAO degrades monoamine
neurotransmitters and food substances or drugs.
-MAO is located in neurons and in the liver. Correct
Answers Monoamine Oxidase Inhibitors (MAOIs)
-Efficacy is well established by research
-Not entirely sure how it works but believe that
because it is a positively charged ion much like
sodium and potassium, it may act by affecting
electrical conductivity in neurons.
-May reduce the excitatory neurotransmitter
glutamate.
-Noncompetitive inhibition of the enzyme inostitol
monophosphatase
-Possibly causes inhibition of serotonin
autoreceptors. Correct Answers Lithium
-Increase both serotonin and norepinephrine.
-In this class of drugs the mechanism of action is
dependent on the drug. Correct Answers
Serotonin-Norepinephrine Reuptake Inhibitors
(SNRIs)
