RATED ANSWERS
Women who have a family history of BRCA1 have a _____ chance of developing breast cancer
50%
BRCA1 and BRCA2 mutations are also associated with what types of cancer? ovarian
prostate
pancreas
_____ events are thought to be the genetic mutations that inappropriately active proto-
oncogenes and inactivate tumor suppressor genes. Initiating
True or False: Proliferation is a requirement for cancer development and it has been suggested
that several mutations may be necessary to achieve fully malignancy? True
The term _____ is applied to agents and substances that are capable of inducing cancer.
List examples. Carcinogens
Ultraviolet and ionizing radiation, certain viruses, asbestos, and numerous chemicals.
, How does inflammation in the body influence tumor growth? Inflammatory cytokines may
cause direct DNA damage and may lead to sustained cellular survival, promotion of growth, and
direct vascularization
______ is the stage during which the mutant cell proliferates Promotion
Most cancer cells begin to synthesize _____ while they acquire their malignant phenotype, thus
rescuing themselves from critical _____ shortening and gaining a mechanism for immortality.
Telomerase
Telomere
_______ is the stage during which the mutant proliferating cells begin to exhibit malignant
behavior. Progression
_____ refers to the cell's traits, such as morphology, metabolism, and biochemical composition.
phenotype
In order to gain access to the blood or lymphatic system for metastasis to occur, cancer cells
must? First escape the basement membrane of the tissue of origin, move through the
extracellular space, and penetrate the basement membrane of the vessel
It is hypothesized that most cancers arise from or contain a small population of _____ which
are present in tissues Stem cells