TOX 2000 - Principles of Toxicology TEST 1 QUESTIONS AND ANSWERS 2025 University of Guelph

TOX 2000 - Principles of Toxicology TEST 1 QUESTIONS AND
ANSWERS 2025 University of Guelph


QUESTIONS AND ANSWERS




1 of 42

Term



Which electrophile is probably the most reactive?
CH3-F
CH3-OH
CH3-Cl
CH3-Br
CH3-I

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F E




D C


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2 of 42

Term



Comparing the toxicity of a toxicant in rats vs. humans could be considered to be an
example of:
A. comparative toxicology
B.epidemiology
C. Bradford-Hill criteria
D.inter-species extrapolation
E.toxicity towards a non-target organism



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A E




D C


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,3 of 42

Term



Which electrophile could be classified as ambident?
A. ethylene oxide
B.aldehyde
C. alpha,beta-unsaturated carbonyl
D.quinone
E.A and B
F.C and D



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E F




D C


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4 of 42

Term


Which statement about metabolism is not true
A. Metabolism allows the enzymatic conversion of chemicals to more polar
compounds
B.Most metabolites are inactivated, or rendered less biologically
active, than the parent compound

, C. Most metabolites tend to be more ionized than the parent compound
at physiological pH
D.The liver is the primary site of xenobiotic metabolism
E. In most cases, therapeutic agents must first be metabolized in order to become
biologically active



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C E




D A


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5 of 42

Term



Which compound has the highest logKow value?
A. Benzene
B.Hexachlorobenzene
C. Pyrene
D.benzo[a]pyrene
E. phenanthrene



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